faculty

Keith Elkon

elkon@uw.edu
Professor

University of Washington

Microbiology, Infection & Immunity

Innate immunity in Systemic Autoimmune Diseases

Faculty Contact Information

Building: South Lake Union Bdg E Room: E541 Box: 358060 Phone: 206-543-3415 https://rheumatology.uw.edu/faculty/keith-b-elkon-md

Research Summary

My laboratory studies molecular mechanisms of autoimmunity with a primary focus on systemic autoimmune diseases such as lupus. Through such studies, we haev experience in both the analysis of B cell immunity through autoantibodies and autoantigens, mechanisms of cell death and inflammation and, most recently, ligands and receptors that regulate interferon (IFN) pathways. We and others have shown that it appears to be predominantly nucleic acids that activate immune sensors leading to IFN and inflammation. We recently highlighted the role of cGAS STING in generation of IFN in autoimmune disease

DEI Statement

Throughout my career I have welcomed students and faculty regardless of background or country of origin. I have opposed discrimination at every level, privately and in public.

Training Summary

Attended video training by Dr. Janice Sabin http://cedi-web01.s.uw.edu/
Participated in Division DEI training at retreat
Participated in Department of Medicine Bias Reduction in Internal Medicine (BRIM)

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["sorttitle"]=> string(99) "properties of the ribosomal p2 protein autoantigen are similar to those of foreign protein antigens" ["volume"]=> string(2) "85" ["issue"]=> string(2) "14" ["pages"]=> string(6) "5186-9" ["lang"]=> array(1) { [0]=> string(3) "eng" } ["nlmuniqueid"]=> string(7) "7505876" ["issn"]=> string(9) "0027-8424" ["essn"]=> string(9) "1091-6490" ["pubtype"]=> array(1) { [0]=> string(15) "Journal Article" } ["recordstatus"]=> string(28) "PubMed - indexed for MEDLINE" ["pubstatus"]=> string(1) "4" ["articleids"]=> array(6) { [0]=> array(3) { ["idtype"]=> string(6) "pubmed" ["idtypen"]=> int(1) ["value"]=> string(7) "2455896" } [1]=> array(3) { ["idtype"]=> string(3) "pmc" ["idtypen"]=> int(8) ["value"]=> string(9) "PMC281713" } [2]=> array(3) { ["idtype"]=> string(3) "doi" ["idtypen"]=> int(3) ["value"]=> string(23) "10.1073/pnas.85.14.5186" } [3]=> array(3) { ["idtype"]=> string(3) "rid" ["idtypen"]=> int(8) ["value"]=> string(7) "2455896" } [4]=> array(3) { ["idtype"]=> string(3) "eid" ["idtypen"]=> int(8) ["value"]=> string(7) "2455896" } [5]=> array(3) { ["idtype"]=> string(5) "pmcid" ["idtypen"]=> int(5) ["value"]=> string(18) "pmc-id: PMC281713;" } } ["history"]=> array(3) { [0]=> array(2) { ["pubstatus"]=> string(6) "pubmed" ["date"]=> string(16) "1988/07/01 00:00" } [1]=> array(2) { ["pubstatus"]=> string(7) "medline" ["date"]=> string(16) "1988/07/01 00:01" } [2]=> array(2) { ["pubstatus"]=> string(6) "entrez" ["date"]=> string(16) "1988/07/01 00:00" } } ["references"]=> array(0) { } ["attributes"]=> array(1) { [0]=> string(12) "Has Abstract" } ["pmcrefcount"]=> int(24) ["fulljournalname"]=> string(79) "Proceedings of the National Academy of Sciences of the United States of America" ["elocationid"]=> string(0) "" ["doctype"]=> string(8) "citation" ["srccontriblist"]=> array(0) { } ["booktitle"]=> string(0) "" ["medium"]=> string(0) "" ["edition"]=> string(0) "" ["publisherlocation"]=> string(0) "" ["publishername"]=> string(0) "" ["srcdate"]=> string(0) "" ["reportnumber"]=> string(0) "" ["availablefromurl"]=> string(0) "" ["locationlabel"]=> string(0) "" ["doccontriblist"]=> array(0) { } ["docdate"]=> string(0) "" ["bookname"]=> string(0) "" ["chapter"]=> string(0) "" ["sortpubdate"]=> string(16) "1988/07/01 00:00" ["sortfirstauthor"]=> string(7) "Elkon K" ["vernaculartitle"]=> string(0) "" } [3382445]=> array(43) { ["uid"]=> string(7) "3382445" ["pubdate"]=> string(8) "1988 Jun" ["epubdate"]=> string(0) "" ["source"]=> string(15) "Arthritis Rheum" ["authors"]=> array(4) { [0]=> array(3) { ["name"]=> string(11) "Lockshin MD" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [1]=> array(3) { ["name"]=> string(7) "Bonfa E" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [2]=> array(3) { ["name"]=> string(7) "Elkon K" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [3]=> array(3) { ["name"]=> string(9) "Druzin ML" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } } ["lastauthor"]=> string(9) "Druzin ML" ["title"]=> string(77) "Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus." ["sorttitle"]=> string(76) "neonatal lupus risk to newborns of mothers with systemic lupus erythematosus" ["volume"]=> string(2) "31" ["issue"]=> string(1) "6" ["pages"]=> string(7) "697-701" ["lang"]=> array(1) { [0]=> string(3) "eng" } ["nlmuniqueid"]=> string(7) "0370605" ["issn"]=> string(9) "0004-3591" ["essn"]=> string(9) "1529-0131" ["pubtype"]=> array(1) { [0]=> string(15) "Journal Article" } ["recordstatus"]=> string(28) "PubMed - indexed for MEDLINE" ["pubstatus"]=> string(1) "4" ["articleids"]=> array(4) { [0]=> array(3) { ["idtype"]=> string(6) "pubmed" ["idtypen"]=> int(1) ["value"]=> string(7) "3382445" } [1]=> array(3) { ["idtype"]=> string(3) "doi" ["idtypen"]=> int(3) ["value"]=> string(22) "10.1002/art.1780310601" } [2]=> array(3) { ["idtype"]=> string(3) "rid" ["idtypen"]=> int(8) ["value"]=> string(7) "3382445" } [3]=> array(3) { ["idtype"]=> string(3) "eid" ["idtypen"]=> int(8) ["value"]=> string(7) "3382445" } } ["history"]=> array(3) { [0]=> array(2) { ["pubstatus"]=> string(6) "pubmed" ["date"]=> string(16) "1988/06/01 00:00" } [1]=> array(2) { ["pubstatus"]=> string(7) "medline" ["date"]=> string(16) "1988/06/01 00:01" } [2]=> array(2) { ["pubstatus"]=> string(6) "entrez" ["date"]=> string(16) "1988/06/01 00:00" } } ["references"]=> array(1) { [0]=> array(4) { ["refsource"]=> string(35) "Arthritis Rheum 1988 Sep;31(9):1203" ["reftype"]=> string(10) "Erratum in" ["pmid"]=> string(0) "" ["note"]=> string(0) "" } } ["attributes"]=> array(1) { [0]=> string(12) "Has Abstract" } ["pmcrefcount"]=> int(6) ["fulljournalname"]=> string(24) "Arthritis and rheumatism" ["elocationid"]=> string(0) "" ["doctype"]=> string(8) "citation" ["srccontriblist"]=> array(0) { } ["booktitle"]=> string(0) "" ["medium"]=> string(0) "" ["edition"]=> string(0) "" ["publisherlocation"]=> string(0) "" ["publishername"]=> string(0) "" ["srcdate"]=> string(0) "" ["reportnumber"]=> string(0) "" ["availablefromurl"]=> string(0) "" ["locationlabel"]=> string(0) "" ["doccontriblist"]=> array(0) { } ["docdate"]=> string(0) "" ["bookname"]=> string(0) "" ["chapter"]=> string(0) "" ["sortpubdate"]=> string(16) "1988/06/01 00:00" ["sortfirstauthor"]=> string(11) "Lockshin MD" ["vernaculartitle"]=> string(0) "" } [2452189]=> array(43) { ["uid"]=> string(7) "2452189" ["pubdate"]=> string(11) "1988 May 15" ["epubdate"]=> string(0) "" ["source"]=> string(9) "J Immunol" ["authors"]=> array(5) { [0]=> array(3) { ["name"]=> string(7) "Bonfa E" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [1]=> array(3) { ["name"]=> string(19) "Marshak-Rothstein A" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [2]=> array(3) { ["name"]=> string(11) "Weissbach H" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [3]=> array(3) { ["name"]=> string(6) "Brot N" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [4]=> array(3) { ["name"]=> string(7) "Elkon K" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } } ["lastauthor"]=> string(7) "Elkon K" ["title"]=> string(139) "Frequency and epitope recognition of anti-ribosome P antibodies from humans with systemic lupus erythematosus and MRL/lpr mice are similar." ["sorttitle"]=> string(138) "frequency and epitope recognition of anti ribosome p antibodies from humans with systemic lupus erythematosus and mrl lpr mice are similar" ["volume"]=> string(3) "140" ["issue"]=> string(2) "10" ["pages"]=> string(6) "3434-7" ["lang"]=> array(1) { [0]=> string(3) "eng" } ["nlmuniqueid"]=> string(8) "2985117R" ["issn"]=> string(9) "0022-1767" ["essn"]=> string(9) "1550-6606" ["pubtype"]=> array(1) { [0]=> string(15) "Journal Article" } ["recordstatus"]=> string(28) "PubMed - indexed for MEDLINE" ["pubstatus"]=> string(1) "4" ["articleids"]=> array(3) { [0]=> array(3) { ["idtype"]=> string(6) "pubmed" ["idtypen"]=> int(1) ["value"]=> string(7) "2452189" } [1]=> array(3) { ["idtype"]=> string(3) "rid" ["idtypen"]=> int(8) ["value"]=> string(7) "2452189" } [2]=> array(3) { ["idtype"]=> string(3) "eid" ["idtypen"]=> int(8) ["value"]=> string(7) "2452189" } } ["history"]=> array(3) { [0]=> array(2) { ["pubstatus"]=> string(6) "pubmed" ["date"]=> string(16) "1988/05/15 00:00" } [1]=> array(2) { ["pubstatus"]=> string(7) "medline" ["date"]=> string(16) "1988/05/15 00:01" } [2]=> array(2) { ["pubstatus"]=> string(6) "entrez" ["date"]=> string(16) "1988/05/15 00:00" } } ["references"]=> array(0) { } ["attributes"]=> array(1) { [0]=> string(12) "Has Abstract" } ["pmcrefcount"]=> int(9) ["fulljournalname"]=> string(45) "Journal of immunology (Baltimore, Md. : 1950)" ["elocationid"]=> string(0) "" ["doctype"]=> string(8) "citation" ["srccontriblist"]=> array(0) { } ["booktitle"]=> string(0) "" ["medium"]=> string(0) "" ["edition"]=> string(0) "" ["publisherlocation"]=> string(0) "" ["publishername"]=> string(0) "" ["srcdate"]=> string(0) "" ["reportnumber"]=> string(0) "" ["availablefromurl"]=> string(0) "" ["locationlabel"]=> string(0) "" ["doccontriblist"]=> array(0) { } ["docdate"]=> string(0) "" ["bookname"]=> string(0) "" ["chapter"]=> string(0) "" ["sortpubdate"]=> string(16) "1988/05/15 00:00" ["sortfirstauthor"]=> string(7) "Bonfa E" ["vernaculartitle"]=> string(0) "" } [3258331]=> array(43) { ["uid"]=> string(7) "3258331" ["pubdate"]=> string(10) "1988 Apr 1" ["epubdate"]=> string(0) "" ["source"]=> string(9) "J Immunol" ["authors"]=> array(3) { [0]=> array(3) { ["name"]=> string(7) "Bonfa E" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [1]=> array(3) { ["name"]=> string(8) "Llovet R" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [2]=> array(3) { ["name"]=> string(7) "Elkon K" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } } ["lastauthor"]=> string(7) "Elkon K" ["title"]=> string(71) "Immunoblot analysis of IgG subclasses of multiple lupus autoantibodies." 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