Research Summary
Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments. The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy, therapeutic resistance, and immune evasion of disseminated tumor cells (DTCs). The ultimate aim is to solve these puzzles and develop therapeutic regimens that prevent metastasis.
For the 2020-2021 acadmeic year, we will be hosting rotation students with the potential of taking two into the lab from Summer 2021 and beyond. See our website for specific project possibilities!
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Publications
The following publications were retrieved from PubMed:
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.
Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D.
Nat Cell Biol. 2019 Nov; 11(21)1403-1412
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.
Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, Ghajar CM.
Nat Cell Biol. 2019 Feb; 2(21)238-250
