Research Summary
Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy, therapeutic resistance, immune evasion and subsequent outgrowth of disseminated tumor cells (DTCs). Our goal is to solve these puzzles and develop therapeutic regimens that eradicate dormant DTCs in order to prevent metastasis.
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Publications
The following publications were retrieved from PubMed:
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.
Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, Ghajar CM.
Nat Cell Biol. 2019 Feb; 2(21)238-250
