faculty

Cyrus Ghajar

cghajar@fredhutch.org

Associate Professor

Fred Hutch

Public Health Sciences

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Tumor dormancy and Metastasis.

Faculty Contact Information

Box: M5-A864 Phone: 206-667-7080 https://www.fredhutch.org/en/labs/profiles/ghajar-cyrus.html

Research Summary

Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments. The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy, therapeutic resistance, and immune evasion of disseminated tumor cells (DTCs). The ultimate aim is to solve these puzzles and develop therapeutic regimens that prevent metastasis.

For the 2021-2022 acadmeic year, we will be hosting rotation students with the potential of taking two into the lab from Summer 2022 and beyond. See our website or better yet get in touch for specific project possibilities!

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Publications

The following publications were retrieved from PubMed:

Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele.

Grzelak CA, Ghajar CM.

Immunohorizons. 2023 Jan 1; 1(7)64-70

Defining cellular population dynamics at single-cell resolution during prostate cancer progression.

Germanos AA, Arora S, Zheng Y, Goddard ET, Coleman IM, Ku AT, Wilkinson S, Song H, Brady NJ, Amezquita RA, Zager M, Long A, Yang YC, Bielas JH, Gottardo R, Rickman DS, Huang FW, Ghajar CM, Nelson PS, Sowalsky AG, Setty M, Hsieh AC.

Elife. 2022 Dec 13; (11)

Metastasis.

Lyden D, Ghajar CM, Correia AL, Aguirre-Ghiso JA, Cai S, Rescigno M, Zhang P, Hu G, Fendt SM, Boire A, Weichselbaum RR, Katipally RR.

Cancer Cell. 2022 Aug 8; 8(40)787-791

Publisher Correction: Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells.

Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM.

Nat Cell Biol. 2022 Jul; 7(24)1177

Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells.

Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM.

Nat Cell Biol. 2022 Apr; 4(24)538-553

PubMed Collection Link

Accepting Students For:

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Lab Information

http://research.fhcrc.org/ghajar/en.html