faculty

Roger Brent

rbrent@fredhutch.org
Professor

Fred Hutch

Cell Signaling & Cell/Environment Interactions

Computational Biology

Genetics, Genomics & Evolution

Ways to make biomedical research go faster

Faculty Contact Information

Building: Weintraub Room: B2-201 Box: A2-205 Phone: 206-667-1482 http://www.brentlab.org/

Research Summary

One project draws on tenets of control theory from human engineering to develop “expression clamped” controllers of mammalian gene expression. The idea is to allow researchers to understand the effects of small differences in protein dosage on phenotype. A second uses digital technology and machine learning to help Augmented Reality (AR) systems provide guidance to researchers performing lab procedures. Both projects further the lab mission of “epistemic support”, to develop tools and methods to accelerate the pace of scientific discovery over the course of the 21st century.

DEI Statement

I grew up in Hattiesburg, Mississippi, in the 1960s. There, I saw enough racism to last a lifetime, and formed political beliefs that have served me well as an adult. The lab has always been woman friendly. Since about 2000, a significant part of lab effort has been outreach to under-represented minority researchers and aggressive attempts to recruit and mentor such persons, while educating everybody about the social structures in which science is embedded. Most of this work has been at the postdoctoral level or higher but we have had PhD students and we now have undergraduates.

Training Summary

I lack formal training in either DEI or mentoring. For DEI, I may (perhaps) partly make up for lack of training by sincerity of deeply held political beliefs and (many) years experience in trying to do the work. For mentoring, I try hard to get people to develop into their best selves intellectually by doing the best science they can.

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Publications

The following publications were retrieved from PubMed:

Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.

Burnaevskiy N, Sands B, Yun S, Tedesco PM, Johnson TE, Kaeberlein M, Brent R, Mendenhall A.

Nat Commun. 2019 Dec 16; 1(10)5725

In vivo measurements reveal a single 5'-intron is sufficient to increase protein expression level in Caenorhabditis elegans.

Crane MM, Sands B, Battaglia C, Johnson B, Yun S, Kaeberlein M, Brent R, Mendenhall A.

Sci Rep. 2019 Jun 24; 1(9)9192

Growth of E. coli on Solid Media.

Elbing KL, Brent R.

Curr Protoc Mol Biol. 2019 Jan; 1(125)e82

Growth of E. coli in Liquid Medium.

Elbing KL, Brent R.

Curr Protoc Mol Biol. 2019 Jan; 1(125)e81

Accepting Students For:

Rotation, Summer

Lab Information

Location: Fred Hutch
Building: Weintraub
Room: B2-201
Box: A2-205