Pacific Northwest Research Institute,
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
Genetics and genomics in yeast
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The genotype-phenotype problem is among the most fundamental in biology. Given the complete genome sequence of an individual, can we predict what traits they will exhibit? We approach this problem using systems genetics, a strategy that integrates the principles and technologies of systems biology with the fundamentals of genetic analysis. We also use the “Awesome Power of Yeast Genetics” to study a diverse array of difficult and important problems, such as the evolution of drug resistance, the modulation of traits by aneuploidy, and the formation of multicellular structures by microbes.