faculty

Aimee Dudley

adudley@pnri.org
Professor

Pacific Northwest Research Institute

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Genetics and genomics in yeast

Faculty Contact Information

Building: 720 Broadway Box: 720 Broadway Phone: 206-726-1237 Alt Phone: 206-726-1200 https://www.pnri.org/research/labs/dudley-lab/

Research Summary

The genotype-phenotype problem is among the most fundamental in biology. Given the complete genome sequence of an individual, can we predict what traits they will exhibit? We approach this problem using a combination of genetics, genomics, and synthetic biology. We are currently using “The Awesome Power of Yeast Genetics” to analyze the functional impact of natural variation in human genes and to develop powerful experimental and statistical resources for delineating the genetic architecture of complex, quantitative traits in S. cerevisiae.

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Publications

The following publications were retrieved from PubMed:

Computational Inference Software for Tetrad Assembly from Randomly Arrayed Yeast Colonies.

Sakhanenko NA, Cromie GA, Dudley AM, Galas DJ.

G3 (Bethesda). 2019 Jul 9; 7(9)2071-2088

Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype.

Forche A, Solis NV, Swidergall M, Thomas R, Guyer A, Beach A, Cromie GA, Le GT, Lowell E, Pavelka N, Berman J, Dudley AM, Selmecki A, Filler SG.

PLoS Genet. 2019 May; 5(15)e1008137

A polyploid admixed origin of beer yeasts derived from European and Asian wine populations.

Fay JC, Liu P, Ong GT, Dunham MJ, Cromie GA, Jeffery EW, Ludlow CL, Dudley AM.

PLoS Biol. 2019 Mar; 3(17)e3000147

Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche in <i>Candida albicans</i>.

Forche A, Cromie G, Gerstein AC, Solis NV, Pisithkul T, Srifa W, Jeffery E, Abbey D, Filler SG, Dudley AM, Berman J.

Genetics. 2018 Jul; 3(209)725-741

Natural Variation in <i>SER1</i> and <i>ENA6</i> Underlie Condition-Specific Growth Defects in <i>Saccharomyces cerevisiae</i>.

Sirr A, Scott AC, Cromie GA, Ludlow CL, Ahyong V, Morgan TS, Gilbert T, Dudley AM.

G3 (Bethesda). 2018 Jan 4; 1(8)239-251

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Lab Information

Location: Pacific Northwest Research Institute
Building: 720 Broadway
Phone: 206-726-1237
Alt Phone: 206-726-1200
https://www.pnri.org/research/labs/dudley-lab/