faculty

Aimee Dudley

adudley@pnri.org
Professor

Pacific Northwest Research Institute

Gene Expression, Cell Cycle & Chromosome Biology

Microbiology, Infection & Immunity

Genetics and genomics in yeast

Faculty Contact Information

Building: 720 Broadway Box: 720 Broadway Phone: 206-726-1237 https://www.pnri.org/research/labs/dudley-lab/

Research Summary

The genotype-phenotype problem is among the most fundamental in biology. Given the complete genome sequence of an individual, can we predict what traits they will exhibit? We approach this problem using a combination of genetics, genomics, and synthetic biology. We are currently using “The Awesome Power of Yeast Genetics” to analyze the functional impact of natural variation in human genes and to develop powerful experimental and statistical resources for delineating the genetic architecture of complex, quantitative traits in S. cerevisiae.

DEI Statement

Every scientific breakthrough starts with someone asking a question that they find personally interesting and important. By increasing the participation of individuals with diverse backgrounds and experiences in biomedical research, we expand the range of questions that get asked, and consequently, the discoveries that get made. Our lab strives to be an inclusive environment because science benefits when individuals from all communities and backgrounds bring their talents and perspectives to the pursuit of discovery. In addition to promoting diversity and inclusion in my own lab, I play an active role at the institutional level. As PNRI’s Director of Educational Outreach, I lead the institute’s initiative to recruit trainees from communities that are underrepresented in STEM and to establish partnerships with DEI-focused nonprofit organizations.

Training Summary

Rainier Scholars Internship Supervisor Training: Best Practices for Supporting BIPOC and First-Gen Students in the Workplace – 2022

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_63915bfe395e202f1245c49c&retmode=json
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Publications

The following publications were retrieved from PubMed:

Quantifying yeast colony morphologies with feature engineering from time-lapse photography.

Goldschmidt A, Kunert-Graf J, Scott AC, Tan Z, Dudley AM, Kutz JN.

Sci Data. 2022 May 17; 1(9)216

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update.

Maddirevula S, Shamseldin HE, Sirr A, AlAbdi L, Lo RS, Ewida N, Al-Qahtani M, Hashem M, Abdulwahab F, Aboyousef O, Kaya N, Monies D, Salem MH, Al Harbi N, Aldhalaan HM, Alzaidan H, Almanea HM, Alsalamah AK, Al Mutairi F, Ismail S, Abdel-Salam GMH, Alhashem A, Asery A, Faqeih E, AlQassmi A, Al-Hamoudi W, Algoufi T, Shagrani M, Dudley AM, Alkuraya FS.

Front Genet. 2020; (11)580484

A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1.

Sirr A, Lo RS, Cromie GA, Scott AC, Ashmead J, Heyesus M, Dudley AM.

J Inherit Metab Dis. 2020 Jul; 4(43)758-769

Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies.

Intosalmi J, Scott AC, Hays M, Flann N, Yli-Harja O, Lähdesmäki H, Dudley AM, Skupin A.

BMC Mol Cell Biol. 2019 Dec 19; 1(20)59

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Lab Information

Location: Pacific Northwest Research Institute
Building: 720 Broadway
Phone: 206-726-1237
Alt Phone: 206-726-1200
https://www.pnri.org/research/labs/dudley-lab/