Research Summary
The genotype-phenotype problem is among the most fundamental in biology. Given the complete genome sequence of an individual, can we predict what traits they will exhibit? We approach this problem using a combination of genetics, genomics, and synthetic biology. We are currently using “The Awesome Power of Yeast Genetics” to analyze the functional impact of natural variation in human genes and to develop powerful experimental and statistical resources for delineating the genetic architecture of complex, quantitative traits in S. cerevisiae.
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Publications
The following publications were retrieved from PubMed:
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype.
Forche A, Solis NV, Swidergall M, Thomas R, Guyer A, Beach A, Cromie GA, Le GT, Lowell E, Pavelka N, Berman J, Dudley AM, Selmecki A, Filler SG.
PLoS Genet. 2019 May; 5(15)e1008137
Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche in <i>Candida albicans</i>.
Forche A, Cromie G, Gerstein AC, Solis NV, Pisithkul T, Srifa W, Jeffery E, Abbey D, Filler SG, Dudley AM, Berman J.
Genetics. 2018 Jul; 3(209)725-741
