Shao-En Ong
shaoen@uw.eduUniversity of Washington,
Biophysical and Structural Biology
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Proteogenomic approaches to study gene regulation and cancer
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both Gαi/o and β-Arrestin Proteins.
Liu Y, Gibson AW, Levinstein MR, Lesiak AJ, Ong SE, Neumaier J.
ACS chemical neuroscience. 2019;
- PMID:
- 30946562
Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD.
The Journal of biological chemistry. 2019; 294(9):3152-3168.
- PMID:
- 30598507
- PMCID:
- PMC6398132
ELTA: Enzymatic Labeling of Terminal ADP-Ribose.
Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL.
Molecular cell. 2019; 73(4):845-856.e5.
- PMID:
- 30712989
Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(49):E11465-E11474.
- PMID:
- 30455320
- PMCID:
- PMC6298107
Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells.
Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT.
Nature chemical biology. 2018; 14(9):844-852.
- PMID:
- 29988067
Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module.
Hsu PL, Li H, Lau HT, Leonen C, Dhall A, Ong SE, Chatterjee C, Zheng N.
Cell. 2018; 174(5):1106-1116.e9. NIHMSID: NIHMS977577
- PMID:
- 30100181
- PMCID:
- PMC6108940
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J.
Molecular cell. 2018; 69(5):787-801.e8. NIHMSID: NIHMS944445
- PMID:
- 29499134
- PMCID:
- PMC5836505
Golkowski M, Perera GK, Vidadala VN, Ojo KK, Van Voorhis WC, Maly DJ, Ong SE.
Molecular omics. 2018; 14(1):26-36. NIHMSID: NIHMS933744
- PMID:
- 29725679
- PMCID:
- PMC5939582
McPherson RL, Ong SE, Leung AKL.
Methods in molecular biology (Clifton, N.J.). 2018; 1813:271-283. NIHMSID: NIHMS1004574
- PMID:
- 30097875
- PMCID:
- PMC6382470
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE, Chavkin C.
Nature communications. 2017; 8(1):743.
- PMID:
- 28963507
- PMCID:
- PMC5622097
Research Summary
Our laboratory focuses on developing and applying novel proteomics approaches to measure proteome-wide changes in post-translational modifications and protein abundances whilst studying protein-protein interactions that dynamically regulate cellular processes like growth and proliferation. Another of our major goals is to integrate genomics and proteomics to study dysregulated signaling in cancer. Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.