faculty

Shao-En Ong

shaoen@uw.edu

Associate Professor

University of Washington

Pharmacology

Biophysical and Structural Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Proteogenomic approaches to study gene regulation and cancer

Faculty Contact Information

Building: HSB Box: 357280 Phone: 206-616-6962

Research Summary

Our laboratory focuses on developing and applying novel proteomics approaches to study dysregulated signaling in cancer. Recently, we used kinobeads to enrich kinases, their interacting proteins, and associated phosphorylation sites to study signaling pathways involved in drug response in liver cancer.

Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.

DEI Statement

I strongly believe in partnering with each trainee to succeed in their goals; this partnership works both ways, to identify and learn both from our strengths and weaknesses. Our lab is passionate about training, hosting other trainees from collaborating groups, undergraduates, and high-school summer research programs. It is through these different experiences that we have expanded our understanding of working with each trainee as individuals.

Training Summary

Equity in Graduate Education Summit – 2021

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Publications

The following publications were retrieved from PubMed:

Reinterpretation of Health Information in the Context of an Emerging Infectious Disease: A Digital Focus Group Study.

Tan RKJ, Lim JM, Neo PHM, Ong SE.

JMIR Hum Factors. 2022 Nov 22; 4(9)e39312

Mislocalization of protein kinase A drives pathology in Cushing's syndrome.

Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrançois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD.

Cell Rep. 2022 Jul 12; 2(40)111073

Water Droplet-in-Oil Digestion Method for Single-Cell Proteomics.

Masuda T, Inamori Y, Furukawa A, Yamahiro M, Momosaki K, Chang CH, Kobayashi D, Ohguchi H, Kawano Y, Ito S, Araki N, Ong SE, Ohtsuki S.

Anal Chem. 2022 Jul 26; 29(94)10329-10336

Time for tobacco-free generations in the Western Pacific?

Amul GGH, Ong SE, Mohd Khalib A, Yoong JS.

Lancet Reg Health West Pac. 2022 Jul; (24)100530

Proteomic Identification of Phosphorylation-Dependent Septin 7 Interactors that Drive Dendritic Spine Formation.

Byeon S, Werner B, Falter R, Davidsen K, Snyder C, Ong SE, Yadav S.

Front Cell Dev Biol. 2022; (10)836746

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