Shao-En Ong
shaoen@uw.eduUniversity of Washington,
Biophysical and Structural Biology
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Proteogenomic approaches to study gene regulation and cancer
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module.
Hsu PL, Li H, Lau HT, Leonen C, Dhall A, Ong SE, Chatterjee C, Zheng N.
Cell. 2018; 174(5):1106-1116.e9. NIHMSID: NIHMS977577
- PMID:
- 30100181
- PMCID:
- PMC6108940
Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.
Golkowski M, Vidadala RS, Lombard CK, Suh HW, Maly DJ, Ong SE.
Journal of proteome research. 2017; 16(3):1216-1227. NIHMSID: NIHMS914829
- PMID:
- 28102076
- PMCID:
- PMC5663466
ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method.
Daniels CM, Ong SE, Leung AKL.
Methods in molecular biology (Clifton, N.J.). 2017; 1608:79-93. NIHMSID: NIHMS965869
- PMID:
- 28695505
- PMCID:
- PMC5956525
SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Shimizu-Albergine M, Van Yserloo B, Golkowski MG, Ong SE, Beavo JA, Bornfeldt KE.
Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(38):E5685-93.
- PMID:
- 27601673
- PMCID:
- PMC5035853
ENPP1 processes protein ADP-ribosylation in vitro.
Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I.
The FEBS journal. 2016; 283(18):3371-88. NIHMSID: NIHMS802715
- PMID:
- 27406238
- PMCID:
- PMC5030157
Golkowski M, Shimizu-Albergine M, Suh HW, Beavo JA, Ong SE.
Cellular signalling. 2016; 28(7):764-78. NIHMSID: NIHMS748416
- PMID:
- 26643407
- PMCID:
- PMC5679091
Mitochondrial dysfunction remodels one-carbon metabolism in human cells.
Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK.
eLife. 2016; 5.
- PMID:
- 27307216
- PMCID:
- PMC4911214
Nudix hydrolases degrade protein-conjugated ADP-ribose.
Daniels CM, Thirawatananond P, Ong SE, Gabelli SB, Leung AK.
Scientific reports. 2015; 5:18271.
- PMID:
- 26669448
- PMCID:
- PMC4680915
The Promise of Proteomics for the Study of ADP-Ribosylation.
Daniels CM, Ong SE, Leung AK.
Molecular cell. 2015; 58(6):911-24. NIHMSID: NIHMS698699
- PMID:
- 26091340
- PMCID:
- PMC4486045
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.
Lafranchi L, de Boer HR, de Vries EG, Ong SE, Sartori AA, van Vugt MA.
The EMBO journal. 2014; 33(23):2860-79.
- PMID:
- 25349192
- PMCID:
- PMC4282561
Research Summary
Our laboratory focuses on developing and applying novel proteomics approaches to measure proteome-wide changes in post-translational modifications and protein abundances whilst studying protein-protein interactions that dynamically regulate cellular processes like growth and proliferation. Another of our major goals is to integrate genomics and proteomics to study dysregulated signaling in cancer. Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.