faculty

Shao-En Ong

shaoen@uw.edu
Associate Professor

University of Washington

Pharmacology

Biophysical and Structural Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Proteogenomic approaches to study gene regulation and cancer

Faculty Contact Information

Building: HSB Box: 357280 Phone: 206-616-6962

Research Summary

Our laboratory focuses on developing and applying novel proteomics approaches to study dysregulated signaling in cancer. Recently, we used kinobeads to enrich kinases, their interacting proteins, and associated phosphorylation sites to study signaling pathways involved in drug response in liver cancer.

Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.

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Publications

The following publications were retrieved from PubMed:

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.

Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD.

Elife. 2019 May 7; (8)

GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.

Cherry AE, Vicente JJ, Xu C, Morrison RS, Ong SE, Wordeman L, Stella N.

Glia. 2019 Aug; 8(67)1558-1570

Peer review and publication delay.

Fernandez-Llimos F, Pharmacy Practice 2018 peer reviewers..

Pharm Pract (Granada). 2019 Jan-Mar; 1(17)1502

5-HT<sub>1B</sub> Receptor-Mediated Activation of ERK1/2 Requires Both Gα<sub>i/o</sub> and β-Arrestin Proteins.

Liu Y, Gibson AW, Levinstein MR, Lesiak AJ, Ong SE, Neumaier JF.

ACS Chem Neurosci. 2019 Jul 17; 7(10)3143-3153

ELTA: Enzymatic Labeling of Terminal ADP-Ribose.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL.

Mol Cell. 2019 Feb 21; 4(73)845-856.e5

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Lab Information

Location: University of Washington
Building: HSB J-wing
Room: J611A-F
Box: Box 357280
Phone: 206-685-1882
http://www.quantbiology.org/