Research Summary
Our laboratory focuses on developing and applying novel proteomics approaches to study dysregulated signaling in cancer. Recently, we used kinobeads to enrich kinases, their interacting proteins, and associated phosphorylation sites to study signaling pathways involved in drug response in liver cancer.
Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.
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Publications
The following publications were retrieved from PubMed:
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.
Gabrovsek L, Collins KB, Aggarwal S, Saunders LM, Lau HT, Suh D, Sancak Y, Trapnell C, Ong SE, Smith FD, Scott JD.
J Biol Chem. 2020 Jun 1;
N-glycosylation of α<sub>1D</sub>-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.
Janezic EM, Lauer SM, Williams RG, Chungyoun M, Lee KS, Navaluna E, Lau HT, Ong SE, Hague C.
Sci Rep. 2020 Apr 29; 1(10)7209
An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.
Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD.
Elife. 2019 May 7; (8)
