faculty

Shao-En Ong

shaoen@uw.edu

University of Washington, 

Biophysical and Structural Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Proteogenomic approaches to study gene regulation and cancer

Faculty Contact Information

Building: HSB Box: 357280 Phone: 206-616-6962

Lab Information

Location: University of Washington Building: HSB J-wing Room: J611A-F Box: Box 357280 Phone: 206-685-1882 http://www.quantbiology.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both Gαi/o and β-Arrestin Proteins.

Liu Y, Gibson AW, Levinstein MR, Lesiak AJ, Ong SE, Neumaier J.

ACS chemical neuroscience. 2019;

PubMed [journal]
PMID:
30946562

Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.

Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD.

The Journal of biological chemistry. 2019; 294(9):3152-3168.

PubMed [journal]
PMID:
30598507
PMCID:
PMC6398132

ELTA: Enzymatic Labeling of Terminal ADP-Ribose.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL.

Molecular cell. 2019; 73(4):845-856.e5.

PubMed [journal]
PMID:
30712989

Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(49):E11465-E11474.

PubMed [journal]
PMID:
30455320
PMCID:
PMC6298107

Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells.

Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT.

Nature chemical biology. 2018; 14(9):844-852.

PubMed [journal]
PMID:
29988067

Research Summary

Our laboratory focuses on developing and applying novel proteomics approaches to measure proteome-wide changes in post-translational modifications and protein abundances whilst studying protein-protein interactions that dynamically regulate cellular processes like growth and proliferation. Another of our major goals is to integrate genomics and proteomics to study dysregulated signaling in cancer. Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.