faculty

Hans-Peter Kiem

hkiem@fhcrc.org

Fred Hutch, 

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Conducting Preclinical and Clinical Studies of Gene Therapy

Faculty Contact Information

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Thomas Box: D1-100 http://labs.fhcrc.org/kiem/index.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.

Peterson CW, Kiem HP.

Cell Stem Cell. 2019 May 2; 5(24)685-687

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Radtke S, Perez AM, Venkataraman R, Reddy S, Haworth KG, Humbert O, Kiem HP, Peterson CW.

J Vis Exp. 2019 Feb 15; 144

The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.

Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2019 Apr 25; 17(133)1876-1887

Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.

Hay KA, Gauthier J, Hirayama AV, Voutsinas JM, Wu Q, Li D, Gooley TA, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Schoch G, Chapuis AG, Till BG, Kiem HP, Ramos JD, Shadman M, Cassaday RD, Acharya UH, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2019 Apr 11; 15(133)1652-1663

TALEN-Mediated Gene Editing of <i>HBG</i> in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.

Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2019 Mar 15; (12)175-183

Research Summary

The Kiem Lab studies cell and gene therapy with a particular interest in the biology of blood and marrow stem cells and the development and use of novel genome editing technologies. The overall goal is to develop better stem cell transplant and cell and gene therapy treatments for patients with genetic and infectious diseases and cancer.