Hans-Peter Kiem
hkiem@fhcrc.orgFred Hutch,
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Conducting Preclinical and Clinical Studies of Gene Therapy
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.
Peterson CW, Kiem HP.
Cell Stem Cell. 2019 May 2; 5(24)685-687
Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.
Radtke S, Perez AM, Venkataraman R, Reddy S, Haworth KG, Humbert O, Kiem HP, Peterson CW.
J Vis Exp. 2019 Feb 15; 144
Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ.
Blood. 2019 Apr 25; 17(133)1876-1887
Hay KA, Gauthier J, Hirayama AV, Voutsinas JM, Wu Q, Li D, Gooley TA, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Schoch G, Chapuis AG, Till BG, Kiem HP, Ramos JD, Shadman M, Cassaday RD, Acharya UH, Riddell SR, Maloney DG, Turtle CJ.
Blood. 2019 Apr 11; 15(133)1652-1663
Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ.
Mol Ther Methods Clin Dev. 2019 Mar 15; (12)175-183
Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A.
Blood Adv. 2019 Feb 12; 3(3)268-274
Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A.
Exp Hematol. 2019 Feb; (70)31-41.e1
Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP.
Mol Ther. 2019 Jan 2; 1(27)164-177
Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS.
Nat Commun. 2018 Oct 25; 1(9)4438
Humbert O, Laszlo GS, Sichel S, Ironside C, Haworth KG, Bates OM, Beddoe ME, Carrillo RR, Kiem HP, Walter RB.
Leukemia. 2019 Mar; 3(33)762-808
Sorting Out the Best: Enriching Hematopoietic Stem Cells for Gene Therapy and Editing.
Radtke S, Humbert O, Kiem HP.
Mol Ther. 2018 Oct 3; 10(26)2328-2329
Cornetta K, Duffy L, Feldman SA, Mackall CL, Davila ML, Curran KJ, Junghans RP, Tang JY, Kochenderfer JN, O'Cearbhaill R, Archer G, Kiem HP, Shah NN, Delbrook C, Kaplan R, Brentjens RJ, Rivière I, Sadelain M, Rosenberg SA.
Mol Ther Methods Clin Dev. 2018 Sep 21; (10)371-378
Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.
J Gene Med. 2018 Oct; 10-11(20)e3050
Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW.
Mol Ther Methods Clin Dev. 2018 Jun 15; (9)347-357
Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.
JCI Insight. 2018 Jul 12; 13(3)
Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP.
Haematologica. 2018 Nov; 11(103)1806-1814
Chimeric antigen receptor T-cell approaches to HIV cure.
Kuhlmann AS, Peterson CW, Kiem HP.
Curr Opin HIV AIDS. 2018 Sep; 5(13)446-453
Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.
Blood Adv. 2018 May 8; 9(2)987-999
Haworth KG, Kiem HP.
Mol Ther. 2018 May 2; 5(26)1167-1168
Peterson CW, Wang J, Deleage C, Reddy S, Kaur J, Polacino P, Reik A, Huang ML, Jerome KR, Hu SL, Holmes MC, Estes JD, Kiem HP.
PLoS Pathog. 2018 Apr; 4(14)e1006956
Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.
Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.
Nat Med. 2018 Apr 10; 4(24)525
Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.
PLoS Pathog. 2018 Mar; 3(14)e1006891
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.
Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.
Nat Med. 2018 Feb; 2(24)239-246
Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.
PLoS Pathog. 2017 Dec; 12(13)e1006753
Humbert O, Peterson CW, Norgaard ZK, Radtke S, Kiem HP.
Mol Ther Methods Clin Dev. 2018 Mar 16; (8)75-86
Cell and Gene Therapy for HIV Cure.
Peterson CW, Kiem HP.
Curr Top Microbiol Immunol. 2018; (417)211-248
Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.
Mol Ther Methods Clin Dev. 2018 Mar 16; (8)52-64
Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.
Sci Transl Med. 2017 Nov 1; 414(9)
Hematopoietic Stem Cell Approaches to Cancer.
Adair JE, Kubek SP, Kiem HP.
Hematol Oncol Clin North Am. 2017 Oct; 5(31)897-912
In Vivo Hematopoietic Stem Cell Transduction.
Richter M, Stone D, Miao C, Humbert O, Kiem HP, Papayannopoulou T, Lieber A.
Hematol Oncol Clin North Am. 2017 Oct; 5(31)771-785
Nanoparticle Biokinetics in Mice and Nonhuman Primates.
Chiarelli PA, Revia RA, Stephen ZR, Wang K, Jeon M, Nelson V, Kievit FM, Sham J, Ellenbogen RG, Kiem HP, Zhang M.
ACS Nano. 2017 Sep 26; 9(11)9514-9524
Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers.
Moffett HF, Coon ME, Radtke S, Stephan SB, McKnight L, Lambert A, Stoddard BL, Kiem HP, Stephan MT.
Nat Commun. 2017 Aug 30; 1(8)389
CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.
Haworth KG, Peterson CW, Kiem HP.
Cytotherapy. 2017 Nov; 11(19)1325-1338
Haworth KG, Ironside C, Norgaard ZK, Obenza WM, Adair JE, Kiem HP.
Mol Ther Methods Clin Dev. 2017 Sep 15; (6)17-30
Twigg HL 3rd, Crystal R, Currier J, Ridker P, Berliner N, Kiem HP, Rutherford G, Zou S, Glynn S, Wong R, Peprah E, Engelgau M, Creazzo T, Colombini-Hatch S, Caler E.
AIDS Res Hum Retroviruses. 2017 Sep; 9(33)889-897
Reeves DB, Peterson CW, Kiem HP, Schiffer JT.
J Virol. 2017 Jul 1; 13(91)
Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ.
Mol Ther Methods Clin Dev. 2017 Mar 17; (4)1-16
Gori JL, Butler JM, Kunar B, Poulos MG, Ginsberg M, Nolan DJ, Norgaard ZK, Adair JE, Rafii S, Kiem HP.
Stem Cells Transl Med. 2017 Mar; 3(6)864-876
Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation.
Peterson CW, Benne C, Polacino P, Kaur J, McAllister CE, Filali-Mouhim A, Obenza W, Pecor TA, Huang ML, Baldessari A, Murnane RD, Woolfrey AE, Jerome KR, Hu SL, Klatt NR, DeRosa S, Sékaly RP, Kiem HP.
JCI Insight. 2017 Feb 23; 4(2)e91230
Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia.
Adair JE, Sevilla J, Heredia CD, Becker PS, Kiem HP, Bueren J.
Curr Gene Ther. 2017; 5(16)338-348
Thakar MS, Bonfim C, Walters MC, Storb R, Pasquini R, Burroughs L, Sandmaier BM, Woolfrey A, Kiem HP.
Bone Marrow Transplant. 2017 Apr; 4(52)570-573
Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation.
Cowan MJ, Kiem HP.
Mol Ther. 2016 Nov; 11(24)1892-1894
Symonds G, Bartlett JS, Kiem HP, Tsie M, Breton L.
AIDS Patient Care STDS. 2016 Dec; 12(30)545-550
Bonfim C, Ribeiro L, Nichele S, Loth G, Bitencourt M, Koliski A, Kuwahara C, Fabro AL, Pereira NF, Pilonetto D, Thakar M, Kiem HP, Page K, Fuchs EJ, Eapen M, Pasquini R.
Biol Blood Marrow Transplant. 2017 Feb; 2(23)310-317
Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.
Blood. 2016 Nov 3; 18(128)2206-2217
A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?
Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC.
Pathog Immun. 2016 Spring; 1(1)154-164
Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.
Nat Commun. 2016 Oct 20; (7)13173
Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.
Mol Ther Nucleic Acids. 2016 Aug 23; 8(5)e352
Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials.
Jenkins CL, Bagarazzi ML, Kiem HP, Levine AJ, Ando D, June CH, Reid T, Emery DW.
Mol Ther. 2016 Aug; 7(24)1173-7
Gallo S, Woolfrey AE, Burroughs LM, Storer BE, Flowers ME, Hari P, Pulsipher MA, Heimfeld S, Kiem HP, Sandmaier BM, Storb R.
Bone Marrow Transplant. 2016 Dec; 12(51)1573-1578
International AIDS Society global scientific strategy: towards an HIV cure 2016.
Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group., Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J.
Nat Med. 2016 Aug; 8(22)839-50
Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP.
Mol Ther. 2016 Aug; 7(24)1237-46
Radtke S, Haworth KG, Kiem HP.
Exp Hematol. 2016 Jun; 6(44)502-7
Peterson CW, Wang J, Norman KK, Norgaard ZK, Humbert O, Tse CK, Yan JJ, Trimble RG, Shivak DA, Rebar EJ, Gregory PD, Holmes MC, Kiem HP.
Blood. 2016 May 19; 20(127)2416-26
Peterson CW, Haworth KG, Burke BP, Polacino P, Norman KK, Adair JE, Hu SL, Bartlett JS, Symonds GP, Kiem HP.
Mol Ther Methods Clin Dev. 2016; (3)16007
Dimitrov DT, Kiem HP, Jerome KR, Johnston C, Schiffer JT.
Sci Rep. 2016 Feb 24; (6)22183
Peterson CW, Haworth KG, Polacino P, Huang ML, Sykes C, Obenza WM, Repetto AC, Kashuba A, Bumgarner R, DeRosa SC, Woolfrey AE, Jerome KR, Mullins JI, Hu SL, Kiem HP.
AIDS. 2015 Aug 24; 13(29)1597-606
Younan PM, Polacino P, Kowalski JP, Hu SL, Kiem HP.
Gene Ther. 2015 Dec; 12(22)1007-12
Johnston C, Harrington R, Jain R, Schiffer J, Kiem HP, Woolfrey A.
Biol Blood Marrow Transplant. 2016 Jan; 1(22)149-56
Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.
BMC Bioinformatics. 2015 Jul 7; (16)212
Burtner CR, Chandrasekaran D, Santos EB, Beard BC, Adair JE, Hamlin DK, Wilbur DS, Sandmaier BM, Kiem HP.
Hum Gene Ther. 2015 Jun; 6(26)399-406
Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD.
Gene Ther. 2015 Jul; 7(22)591-5
C peptides as entry inhibitors for gene therapy.
Egerer L, Kiem HP, von Laer D.
Adv Exp Med Biol. 2015; (848)191-209
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Gori JL, Butler JM, Chan YY, Chandrasekaran D, Poulos MG, Ginsberg M, Nolan DJ, Elemento O, Wood BL, Adair JE, Rafii S, Kiem HP.
J Clin Invest. 2015 Mar 2; 3(125)1243-54
Younan PM, Peterson CW, Polacino P, Kowalski JP, Obenza W, Miller HW, Milless BP, Gafken P, DeRosa SC, Hu SL, Kiem HP.
Mol Ther. 2015 May; 5(23)943-951
Gene therapy studies in a canine model of X-linked severe combined immunodeficiency.
Felsburg PJ, De Ravin SS, Malech HL, Sorrentino BP, Burtner C, Kiem HP.
Hum Gene Ther Clin Dev. 2015 Mar; 1(26)50-6
Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.
Science. 2014 Sep 19; 6203(345)1509-12
T-cell immunotherapy: looking forward.
Corrigan-Curay J, Kiem HP, Baltimore D, O'Reilly M, Brentjens RJ, Cooper L, Forman S, Gottschalk S, Greenberg P, Junghans R, Heslop H, Jensen M, Mackall C, June C, Press O, Powell D, Ribas A, Rosenberg S, Sadelain M, Till B, Patterson AP, Jambou RC, Rosenthal E, Gargiulo L, Montgomery M, Kohn DB.
Mol Ther. 2014 Sep; 9(22)1564-74
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL, Bridge CA, Hawkins-Daarud A, Gori JL, Born DE, Gonzalez-Cuyar LF, Silbergeld DL, Rockne RC, Storer BE, Rockhill JK, Swanson KR, Kiem HP.
J Clin Invest. 2014 Sep; 9(124)4082-92
High-throughput genomic mapping of vector integration sites in gene therapy studies.
Beard BC, Adair JE, Trobridge GD, Kiem HP.
Methods Mol Biol. 2014; (1185)321-44
Charting a clear path: the ASGCT Standardized Pathways Conference.
Kiem HP, Baum C, Bushman FD, Byrne BJ, Carter BJ, Cavagnaro J, Malech HL, Mendell JR, Naldini LM, Sorrentino BP, Williams DA, Flotte TR.
Mol Ther. 2014 Jul; 7(22)1235-1238
Modeling promising nonmyeloablative conditioning regimens in nonhuman primates.
Chandrasekaran D, Nakamoto B, Watts KL, Kiem HP, Papayannopoulou T.
Hum Gene Ther. 2014 Dec; 12(25)1013-22
Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE.
Blood. 2014 Aug 7; 6(124)913-23
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE.
Nature. 2014 Jun 12; 7504(510)273-7
HIV eradication--from Berlin to Boston.
Cannon PM, Kohn DB, Kiem HP.
Nat Biotechnol. 2014 Apr; 4(32)315-6
Watts KL, Beard BC, Wood BL, Trobridge GD, Humphries RK, Adams AB, Nelson V, Kiem HP.
Exp Hematol. 2014 Jul; 7(42)497-504
Intravenous injection of a foamy virus vector to correct canine SCID-X1.
Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP.
Blood. 2014 Jun 5; 23(123)3578-84
Wurm M, Kowalski J, Heckl D, Zhang XB, Nelson V, Beard BC, Kiem HP.
Exp Hematol. 2014 Feb; 2(42)114-25.e4
Fong DL, Torrence AE, Vogel KW, Stockinger DE, Nelson V, Murnane RD, Baldessari A, Kuller L, Agy M, Kiem HP, Hotchkiss CE.
Comp Med. 2014 Feb; 1(64)63-7
Matrajt L, Younan PM, Kiem HP, Schiffer JT.
J Virol. 2014 Mar; 6(88)3202-12
Kiem HP, Arumugam PI, Burtner CR, Fox CF, Beard BC, Dexheimer P, Adair JE, Malik P.
Mol Ther Methods Clin Dev. 2014; (1)14055
Genetic modification of hematopoietic stem cells as a therapy for HIV/AIDS.
Younan P, Kowalski J, Kiem HP.
Viruses. 2013 Nov 28; 12(5)2946-62
Younan P, Kowalski J, Kiem HP.
Mol Ther. 2014 Feb; 2(22)257-264
Peterson CW, Younan P, Polacino PS, Maurice NJ, Miller HW, Prlic M, Jerome KR, Woolfrey AE, Hu SL, Kiem HP.
J Med Primatol. 2013 Oct; 5(42)237-46
Sourisseau M, Goldman O, He W, Gori JL, Kiem HP, Gouon-Evans V, Evans MJ.
Gastroenterology. 2013 Nov; 5(145)966-969.e7
Younan PM, Polacino P, Kowalski JP, Peterson CW, Maurice NJ, Williams NP, Ho O, Trobridge GD, Von Laer D, Prlic M, Beard BC, DeRosa S, Hu SL, Kiem HP.
Blood. 2013 Jul 11; 2(122)179-87
Gori JL, Beard BC, Williams NP, Ironside C, Swanson D, Scott McIvor R, Kiem HP.
J Gene Med. 2013 Jun-Jul; 6-7(15)233-41
Watts KL, Delaney C, Nelson V, Trobridge GD, Beard BC, Humphries RK, Kiem HP.
Mol Ther. 2013 Jun; 6(21)1270-8
Targeted gene disruption to cure HIV.
Stone D, Kiem HP, Jerome KR.
Curr Opin HIV AIDS. 2013 May; 3(8)217-23
Berger C, Berger M, Beard BC, Kiem HP, Gooley TA, Riddell SR.
PLoS One. 2013; 2(8)e56268
Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART.
Peterson CW, Younan P, Jerome KR, Kiem HP.
Gene Ther. 2013 Jul; 7(20)695-702
Large animal models for foamy virus vector gene therapy.
Trobridge GD, Horn PA, Beard BC, Kiem HP.
Viruses. 2012 Dec 7; 12(4)3572-88
Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.
Trobridge GD, Beard BC, Wu RA, Ironside C, Malik P, Kiem HP.
PLoS One. 2012; 9(7)e45173
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM.
Nat Methods. 2012 Oct; 10(9)973-5
Chemoprotection in glioblastoma therapy: reality or a dream?
Mrugala MM, Adair J, Kiem HP.
CNS Oncol. 2012 Sep; 1(1)11-4
Gori JL, Chandrasekaran D, Kowalski JP, Adair JE, Beard BC, D'Souza SL, Kiem HP.
Blood. 2012 Sep 27; 13(120)e35-44
Thakar MS, Bonfim C, Sandmaier BM, O'Donnell P, Ribeiro L, Gooley T, Deeg HJ, Flowers ME, Pasquini R, Storb R, Woolfrey AE, Kiem HP.
Pediatr Hematol Oncol. 2012 Sep; 6(29)568-78
Current translational and clinical practices in hematopoietic cell and gene therapy.
Digiusto DL, Kiem HP.
Cytotherapy. 2012 Aug; 7(14)775-90
Abrogated cryptic activation of lentiviral transfer vectors.
Luche RM, Enssle J, Kiem HP.
Sci Rep. 2012; (2)438
Adair JE, Zhao X, Chien S, Fang M, Wohlfahrt ME, Trobridge GD, Taylor JA, Beard BC, Kiem HP, Becker PS.
J Mol Med (Berl). 2012 Nov; 11(90)1283-94
Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB.
Mol Ther. 2012 Jun; 6(20)1084-94
Gori JL, Beard BC, Ironside C, Karponi G, Kiem HP.
Cancer Gene Ther. 2012 Aug; 8(19)523-9
Extended survival of glioblastoma patients after chemoprotective HSC gene therapy.
Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL, Mrugala MM, Kiem HP.
Sci Transl Med. 2012 May 9; 133(4)133ra57
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Kiem HP, Jerome KR, Deeks SG, McCune JM.
Cell Stem Cell. 2012 Feb 3; 2(10)137-47
Outside the box--novel therapeutic strategies for glioblastoma.
Mrugala MM, Adair JE, Kiem HP.
Cancer J. 2012 Jan-Feb; 1(18)51-8
Gene therapy for Fanconi anemia: one step closer to the clinic.
Tolar J, Becker PS, Clapp DW, Hanenberg H, de Heredia CD, Kiem HP, Navarro S, Qasba P, Rio P, Schmidt M, Sevilla J, Verhoeyen E, Thrasher AJ, Bueren J.
Hum Gene Ther. 2012 Feb; 2(23)141-4
Watts KL, Nelson V, Wood BL, Trobridge GD, Beard BC, Humphries RK, Kiem HP.
Exp Hematol. 2012 Mar; 3(40)187-96
Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.
Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP.
Nucleic Acids Res. 2012 Jan; 2(40)e14
Corrigendum to "Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs".
Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Torok-Storb B, Kiem HP, Blau CA.
Mol Ther. 2011 Nov; 11(19)2102
Hematopoietic stem cell expansion and gene therapy.
Watts KL, Adair J, Kiem HP.
Cytotherapy. 2011 Nov; 10(13)1164-71
Watts KL, Zhang X, Beard BC, Chiu SY, Trobridge GD, Humphries RK, Kiem HP.
Hum Gene Ther. 2011 Dec; 12(22)1475-82
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
Persson J, Beyer I, Yumul R, Li Z, Kiem HP, Roffler S, Lieber A.
PLoS One. 2011; 7(6)e22303
Safeguarding nonhuman primate iPS cells with suicide genes.
Zhong B, Watts KL, Gori JL, Wohlfahrt ME, Enssle J, Adair JE, Kiem HP.
Mol Ther. 2011 Sep; 9(19)1667-75
Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R, Rio P, Sevilla J, Schmidt M, Verhoeyen E, Wagner JE, Williams DA, Thrasher AJ.
Mol Ther. 2011 Jul; 7(19)1193-8
Inamoto Y, Flowers ME, Appelbaum FR, Carpenter PA, Deeg HJ, Furlong T, Kiem HP, Mielcarek M, Nash RA, Storb RF, Witherspoon RP, Storer BE, Martin PJ.
Biol Blood Marrow Transplant. 2011 Jul; 7(17)1088-92
Long-term regulation of genetically modified primary hematopoietic cells in dogs.
Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Torok-Storb B, Kiem HP, Blau CA.
Mol Ther. 2011 Jul; 7(19)1287-94
Flowers ME, Inamoto Y, Carpenter PA, Lee SJ, Kiem HP, Petersdorf EW, Pereira SE, Nash RA, Mielcarek M, Fero ML, Warren EH, Sanders JE, Storb RF, Appelbaum FR, Storer BE, Martin PJ.
Blood. 2011 Mar 17; 11(117)3214-9
Temozolomide: Expanding its role in brain cancer.
Mrugala MM, Adair J, Kiem HP.
Drugs Today (Barc). 2010 Nov; 11(46)833-46
Efficient generation of nonhuman primate induced pluripotent stem cells.
Zhong B, Trobridge GD, Zhang X, Watts KL, Ramakrishnan A, Wohlfahrt M, Adair JE, Kiem HP.
Stem Cells Dev. 2011 May; 5(20)795-807
Imren S, Zhang XB, Humphries RK, Kiem HP.
Exp Hematol. 2011 Jan; 1(39)124-32
Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.
Watts KL, Delaney C, Humphries RK, Bernstein ID, Kiem HP.
Blood. 2010 Dec 23; 26(116)5859-66
Murnane R, Zhang XB, Hukkanen RR, Vogel K, Kelley S, Kiem HP.
Vet Pathol. 2011 Sep; 5(48)999-1001
Thakar MS, Santos EB, Gooley TA, Sale G, Storb R, Kiem HP, Sandmaier BM.
Transplantation. 2010 Jul 15; 1(90)14-22
Thakar MS, Kurre P, Storb R, Kletzel M, Frangoul H, Pulsipher MA, Leisenring W, Flowers ME, Sandmaier BM, Woolfrey A, Kiem HP.
Bone Marrow Transplant. 2011 Apr; 4(46)539-44
Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem HP.
J Clin Invest. 2010 Jul; 7(120)2345-54
Becker PS, Taylor JA, Trobridge GD, Zhao X, Beard BC, Chien S, Adair J, Kohn DB, Wagner JE, Shimamura A, Kiem HP.
Gene Ther. 2010 Oct; 10(17)1244-52
Kiem HP, Ironside C, Beard BC, Trobridge GD.
Exp Hematol. 2010 Sep; 9(38)819-22, 822.e1-3
Large animal models of hematopoietic stem cell gene therapy.
Trobridge GD, Kiem HP.
Gene Ther. 2010 Aug; 8(17)939-48
Sangiolo D, Storb R, Deeg HJ, Flowers ME, Martin PJ, Sandmaier BM, Kiem HP, Nash RA, Doney K, Leisenring WM, Georges GE.
Biol Blood Marrow Transplant. 2010 Oct; 10(16)1411-8
Trobridge GD, Wu RA, Hansen M, Ironside C, Watts KL, Olsen P, Beard BC, Kiem HP.
Mol Ther. 2010 Apr; 4(18)725-33
Enssle J, Trobridge GD, Keyser KA, Ironside C, Beard BC, Kiem HP.
Hum Gene Ther. 2010 Apr; 4(21)397-403
Trobridge GD, Wu RA, Beard BC, Chiu SY, Muñoz NM, von Laer D, Rossi JJ, Kiem HP.
PLoS One. 2009 Nov 2; 11(4)e7693
Hukkanen RR, Gillen M, Grant R, Liggitt HD, Kiem HP, Kelley ST.
Comp Med. 2009 Oct; 5(59)482-7
The effect of imatinib on cytomegalovirus reactivation in hematopoietic cell transplantation.
Travi G, Pergam SA, Xie H, Carpenter P, Kiem HP, Corey L, Boeckh MJ.
Clin Infect Dis. 2009 Dec 1; 11(49)e120-3
Ex vivo expansion and lentiviral transduction of Macaca nemestrina CD4+ T cells.
Muñoz NM, Trobridge GD, Kiem HP.
J Med Primatol. 2009 Dec; 6(38)438-43
Kiem HP, Wu RA, Sun G, von Laer D, Rossi JJ, Trobridge GD.
Gene Ther. 2010 Jan; 1(17)37-49
Myeloablative irradiation in non-human primates.
Watts KL, Beard BC, Wood BL, Kiem HP.
J Med Primatol. 2009 Dec; 6(38)425-32
Thakar MS, Zhang XB, Beard BC, Sale GE, Santos EB, Peterson L, Kiem HP, Sandmaier BM.
Exp Hematol. 2009 Oct; 10(37)1157-66
Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD.
Vigorito AC, Campregher PV, Storer BE, Carpenter PA, Moravec CK, Kiem HP, Fero ML, Warren EH, Lee SJ, Appelbaum FR, Martin PJ, Flowers ME, National Institutes of Health..
Blood. 2009 Jul 16; 3(114)702-8
Carnevale-Schianca F, Leisenring W, Martin PJ, Furlong T, Schoch G, Anasetti C, Appelbaum FR, Carpenter PA, Deeg HJ, Kiem HP, Storb R, McDonald GB, Nash RA.
Biol Blood Marrow Transplant. 2009 Jun; 6(15)749-56
Concurrent blockade of alpha4-integrin and CXCR4 in hematopoietic stem/progenitor cell mobilization.
Bonig H, Watts KL, Chang KH, Kiem HP, Papayannopoulou T.
Stem Cells. 2009 Apr; 4(27)836-7
Beard BC, Sud R, Keyser KA, Ironside C, Neff T, Gerull S, Trobridge GD, Kiem HP.
Blood. 2009 May 21; 21(113)5094-103
Toward a stem cell gene therapy for breast cancer.
Li Z, Liu Y, Tuve S, Xun Y, Fan X, Min L, Feng Q, Kiviat N, Kiem HP, Disis ML, Lieber A.
Blood. 2009 May 28; 22(113)5423-33
Foamy and lentiviral vectors transduce canine long-term repopulating cells at similar efficiency.
Trobridge GD, Allen J, Peterson L, Ironside C, Russell DW, Kiem HP.
Hum Gene Ther. 2009 May; 5(20)519-23
Canine models of gene-modified hematopoiesis.
Beard BC, Kiem HP.
Methods Mol Biol. 2009; (506)341-61
Flowers ME, Storer B, Carpenter P, Rezvani AR, Vigorito AC, Campregher PV, Moravec C, Kiem HP, Fero M, Georges G, Warren E, Lee S, Sanders JE, Appelbaum F, Martin PJ.
Biol Blood Marrow Transplant. 2008 Dec; 12(14)1380-4
Bonig H, Priestley GV, Wohlfahrt M, Kiem HP, Papayannopoulou T.
Stem Cells Dev. 2009 Jul-Aug; 6(18)839-44
Seal S, Hockenbery DM, Spaulding EY, Kiem HP, Abbassi N, Deeg HJ.
Exp Hematol. 2008 Dec; 12(36)1660-72
NOD/SCID repopulating cells contribute only to short-term repopulation in the baboon.
Mezquita P, Beard BC, Kiem HP.
Gene Ther. 2008 Nov; 21(15)1460-2
Furlong T, Kiem HP, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Flowers ME, Mielcarek M, Nash RA, Storb R, Martin PJ.
Biol Blood Marrow Transplant. 2008 May; 5(14)531-7
Wang H, Cao H, Wohlfahrt M, Kiem HP, Lieber A.
Exp Hematol. 2008 Jul; 7(36)823-31
Trobridge GD, Beard BC, Gooch C, Wohlfahrt M, Olsen P, Fletcher J, Malik P, Kiem HP.
Blood. 2008 Jun 15; 12(111)5537-43
Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK, Kiem HP.
J Clin Invest. 2008 Apr; 4(118)1502-10
Piasecki JC, Beagles K, Beard BC, Riddell S, Kiem HP.
Hum Gene Ther. 2008 Jan; 1(19)103-7
Gene therapy in the transplantation of allogeneic organs and stem cells.
Horn PA, Figueiredo C, Kiem HP.
Curr Gene Ther. 2007 Dec; 6(7)458-68
Bonfim CM, de Medeiros CR, Bitencourt MA, Zanis-Neto J, Funke VA, Setubal DC, Ruiz J, Sanders JE, Flowers ME, Kiem HP, Storb R, Pasquini R.
Biol Blood Marrow Transplant. 2007 Dec; 12(13)1455-60
Wohlfahrt ME, Beard BC, Lieber A, Kiem HP.
Cancer Res. 2007 Sep 15; 18(67)8783-90
Sangiolo D, Lesnikova M, Nash RA, Jensen MC, Nikitine A, Kiem HP, Georges GE.
Gene Ther. 2007 Nov; 21(14)1549-54
Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation.
Keyser KA, Beagles KE, Kiem HP.
Cell Transplant. 2007; 5(16)555-62
Jung CW, Beard BC, Morris JC, Neff T, Beebe K, Storer BE, Kiem HP.
Exp Hematol. 2007 Jul; 7(35)1132-9
Gerull S, Beard BC, Peterson LJ, Neff T, Kiem HP.
Hum Gene Ther. 2007 May; 5(18)451-6
Hematopoietic stem-cell behavior in nonhuman primates.
Shepherd BE, Kiem HP, Lansdorp PM, Dunbar CE, Aubert G, LaRochelle A, Seggewiss R, Guttorp P, Abkowitz JL.
Blood. 2007 Sep 15; 6(110)1806-13
Beard BC, Keyser KA, Trobridge GD, Peterson LJ, Miller DG, Jacobs M, Kaul R, Kiem HP.
Hum Gene Ther. 2007 May; 5(18)423-34
Zhang XB, Schwartz JL, Humphries RK, Kiem HP.
Stem Cells. 2007 Aug; 8(25)2074-81
Ying SX, Seal S, Abbassi N, Hockenbery DM, Kiem HP, Li X, Pagel JM, Gopal AK, Deeg HJ.
Leuk Lymphoma. 2007 May; 5(48)1003-14
Beard BC, Dickerson D, Beebe K, Gooch C, Fletcher J, Okbinoglu T, Miller DG, Jacobs MA, Kaul R, Kiem HP, Trobridge GD.
Mol Ther. 2007 Jul; 7(15)1356-65
Neff T, Gerull S, Peterson LJ, Kiem HP.
J Gene Med. 2007 May; 5(9)357-61
Aker M, Tubb J, Groth AC, Bukovsky AA, Bell AC, Felsenfeld G, Kiem HP, Stamatoyannopoulos G, Emery DW.
Hum Gene Ther. 2007 Apr; 4(18)333-43
Storek J, Kiem HP.
Stem Cells Dev. 2006 Oct; 5(15)619-21
Foamy-virus-mediated gene transfer to canine repopulating cells.
Kiem HP, Allen J, Trobridge G, Olson E, Keyser K, Peterson L, Russell DW.
Blood. 2007 Jan 1; 1(109)65-70
Expansion of SCID repopulating cells does not prove expansion of hematopoietic stem cells.
Horn PA, Kiem HP.
Blood. 2006 Jul 15; 2(108)771; author reply 771-2
Placantonakis DG, Bukovsky AA, Aicher SA, Kiem HP, Welsh JP.
J Neurosci. 2006 May 10; 19(26)5008-16
Complications of a temozolomide overdose: a case report.
Spence AM, Kiem HP, Partap S, Schuetze S, Silber JR, Peterson RA.
J Neurooncol. 2006 Oct; 1(80)57-61
Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells.
Zhang XB, Beard BC, Beebe K, Storer B, Humphries RK, Kiem HP.
PLoS Med. 2006 May; 5(3)e173
Deeg HJ, Storer BE, Boeckh M, Martin PJ, McCune JS, Myerson D, Heimfeld S, Flowers ME, Anasetti C, Doney KC, Hansen JA, Kiem HP, Nash RA, O'Donnell PV, Radich JP, Sandmaier BM, Scott BL, Sorror ML, Warren EH, Witherspoon RP, Woolfrey A, Appelbaum FR, Storb R.
Biol Blood Marrow Transplant. 2006 May; 5(12)573-84
Beard BC, Mezquita P, Morris JC, Kiem HP.
Mol Ther. 2006 Aug; 2(14)212-7
Foamy virus vector integration sites in normal human cells.
Trobridge GD, Miller DG, Jacobs MA, Allen JM, Kiem HP, Kaul R, Russell DW.
Proc Natl Acad Sci U S A. 2006 Jan 31; 5(103)1498-503
Hematopoietic stem cell transduction and amplification in large animal models.
Trobridge G, Beard BC, Kiem HP.
Hum Gene Ther. 2005 Dec; 12(16)1355-66
Survival of the fittest: in vivo selection and stem cell gene therapy.
Neff T, Beard BC, Kiem HP.
Blood. 2006 Mar 1; 5(107)1751-60
Kurre P, Anandakumar P, Kiem HP.
Gene Ther. 2006 Feb; 4(13)369-73
Keyser KA, Morris JC, Kiem HP.
Cytotherapy. 2005; 4(7)345-52
Nash RA, Johnston L, Parker P, McCune JS, Storer B, Slattery JT, Furlong T, Anasetti C, Appelbaum FR, Lloid ME, Deeg HJ, Kiem HP, Martin PJ, Schubert MM, Witherspoon RP, Forman SJ, Blume KG, Storb R.
Biol Blood Marrow Transplant. 2005 Jul; 7(11)495-505
Zanis-Neto J, Flowers ME, Medeiros CR, Bitencourt MA, Bonfim CM, Setúbal DC, Funke V, Sanders J, Deeg HJ, Kiem HP, Martin P, Leisenring W, Storb R, Pasquini R.
Br J Haematol. 2005 Jul; 1(130)99-106
Beagles KE, Peterson L, Zhang X, Morris J, Kiem HP.
Hum Gene Ther. 2005 Jun; 6(16)725-33
Ni S, Bernt K, Gaggar A, Li ZY, Kiem HP, Lieber A.
Hum Gene Ther. 2005 Jun; 6(16)664-77
Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan.
Harkey MA, Czerwinski M, Slattery J, Kiem HP.
Cancer Invest. 2005; 1(23)19-25
Interleukin-7 improves reconstitution of antiviral CD4 T cells.
Lu H, Zhao Z, Kalina T, Gillespy T 3rd, Liggitt D, Andrews RG, Maloney DG, Kiem HP, Storek J.
Clin Immunol. 2005 Jan; 1(114)30-41
Neff T, Beard BC, Peterson LJ, Anandakumar P, Thompson J, Kiem HP.
Blood. 2005 Feb 1; 3(105)997-1002
De novo generation of CD4 T cells against viruses present in the host during immune reconstitution.
Kalina T, Lu H, Zhao Z, Blewett E, Dittmer DP, Randolph-Habecker J, Maloney DG, Andrews RG, Kiem HP, Storek J.
Blood. 2005 Mar 15; 6(105)2410-4
Differences in F36VMpl-based in vivo selection among large animal models.
Richard RE, De Claro RA, Yan J, Chien S, Von Recum H, Morris J, Kiem HP, Dalgarno DC, Heimfeld S, Clackson T, Andrews R, Blau CA.
Mol Ther. 2004 Oct; 4(10)730-40
Walter RB, Raden BW, Thompson J, Flowers DA, Kiem HP, Bernstein ID, Linenberger ML.
Leukemia. 2004 Nov; 11(18)1914-7
Platzbecker U, Kurre P, Guardiola P, Ward JL, Radich JP, Kiem HP, Deeg HJ.
Exp Hematol. 2004 Sep; 9(32)815-21
Stem cell gene transfer--efficacy and safety in large animal studies.
Horn PA, Morris JC, Neff T, Kiem HP.
Mol Ther. 2004 Sep; 3(10)417-31
Duration of immunosuppressive treatment for chronic graft-versus-host disease.
Stewart BL, Storer B, Storek J, Deeg HJ, Storb R, Hansen JA, Appelbaum FR, Carpenter PA, Sanders JE, Kiem HP, Nash RA, Petersdorf EW, Moravec C, Morton AJ, Anasetti C, Flowers ME, Martin PJ.
Blood. 2004 Dec 1; 12(104)3501-6
Radiation-induced glioblastoma multiforme in two adult baboons (Papio cynocephalus anubis).
Schielke JE, Kiem HP, Liggitt D, Bielefeldt-Ohmann H.
Comp Med. 2004 Jun; 3(54)327-32
Kurre P, Anandakumar P, Harkey MA, Thomasson B, Kiem HP.
Mol Ther. 2004 Jun; 6(9)914-22
Bielefeldt-Ohmann H, Gough M, Durning M, Kelley S, Liggitt HD, Kiem HP.
J Comp Pathol. 2004 Jul; 1(131)77-86
Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.
Placantonakis DG, Bukovsky AA, Zeng XH, Kiem HP, Welsh JP.
Proc Natl Acad Sci U S A. 2004 May 4; 18(101)7164-9
Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, Nienhuis A, Blau CA, Andrews RG, Donahue RE, Dunbar CE.
Mol Ther. 2004 Mar; 3(9)389-95
Neff T, Peterson LJ, Morris JC, Thompson J, Zhang X, Horn PA, Thomasson BM, Kiem HP.
Mol Ther. 2004 Feb; 2(9)157-9
Horn PA, Keyser KA, Peterson LJ, Neff T, Thomasson BM, Thompson J, Kiem HP.
Blood. 2004 May 15; 10(103)3710-6
Thomasson B, Peterson L, Thompson J, Goerner M, Kiem HP.
Hum Gene Ther. 2003 Nov 20; 17(14)1683-6
Neff T, Horn PA, Peterson LJ, Thomasson BM, Thompson J, Williams DA, Schmidt M, Georges GE, von Kalle C, Kiem HP.
J Clin Invest. 2003 Nov; 10(112)1581-8
Morris JC, Conerly M, Thomasson B, Storek J, Riddell SR, Kiem HP.
Blood. 2004 Jan 15; 2(103)492-9
Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.
Tiede A, Eder M, von Depka M, Battmer K, Luther S, Kiem HP, Ganser A, Scherr M.
Gene Ther. 2003 Oct; 22(10)1917-25
Allogeneic hematopoietic stem cell transplantation for myelofibrosis.
Deeg HJ, Gooley TA, Flowers ME, Sale GE, Slattery JT, Anasetti C, Chauncey TR, Doney K, Georges GE, Kiem HP, Martin PJ, Petersdorf EW, Radich J, Sanders JE, Sandmaier BM, Warren EH, Witherspoon RP, Storb R, Appelbaum FR.
Blood. 2003 Dec 1; 12(102)3912-8
Kohn DB, Sadelain M, Dunbar C, Bodine D, Kiem HP, Candotti F, Tisdale J, Riviére I, Blau CA, Richard RE, Sorrentino B, Nolta J, Malech H, Brenner M, Cornetta K, Cavagnaro J, High K, Glorioso J, American Society of Gene Therapy (ASGT)..
Mol Ther. 2003 Aug; 2(8)180-7
Kurre P, Morris J, Thomasson B, Kohn DB, Kiem HP.
Blood. 2003 Nov 1; 9(102)3117-9
Kurre P, Pulsipher M, Woolfrey A, Maris M, Sandmaier B, Kiem HP, Storb R.
J Pediatr Hematol Oncol. 2003 Jul; 7(25)581-3
Horn PA, Thomasson BM, Wood BL, Andrews RG, Morris JC, Kiem HP.
Blood. 2003 Dec 15; 13(102)4329-35
Schmidt M, Glimm H, Wissler M, Hoffmann G, Olsson K, Sellers S, Carbonaro D, Tisdale JF, Leurs C, Hanenberg H, Dunbar CE, Kiem HP, Karlsson S, Kohn DB, Williams D, Von Kalle C.
Ann N Y Acad Sci. 2003 May; (996)112-21
Storek J, Gillespy T 3rd, Lu H, Joseph A, Dawson MA, Gough M, Morris J, Hackman RC, Horn PA, Sale GE, Andrews RG, Maloney DG, Kiem HP.
Blood. 2003 May 15; 10(101)4209-18
Kurre P, Anandakumar P, Grompe M, Kiem HP.
Exp Hematol. 2002 Nov; 11(30)1257-62
Horn PA, Topp MS, Morris JC, Riddell SR, Kiem HP.
Blood. 2002 Dec 1; 12(100)3960-7
Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons.
Horn PA, Morris JC, Bukovsky AA, Andrews RG, Naldini L, Kurre P, Kiem HP.
Gene Ther. 2002 Nov; 21(9)1464-71
Polyclonal long-term repopulating stem cell clones in a primate model.
Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C.
Blood. 2002 Oct 15; 8(100)2737-43
Pharmacologically regulated in vivo selection in a large animal.
Neff T, Horn PA, Valli VE, Gown AM, Wardwell S, Wood BL, von Kalle C, Schmidt M, Peterson LJ, Morris JC, Richard RE, Clackson T, Kiem HP, Blau CA.
Blood. 2002 Sep 15; 6(100)2026-31
Kondo E, Topp MS, Kiem HP, Obata Y, Morishima Y, Kuzushima K, Tanimoto M, Harada M, Takahashi T, Akatsuka Y.
J Immunol. 2002 Aug 15; 4(169)2164-71
Deeg HJ, Storer B, Slattery JT, Anasetti C, Doney KC, Hansen JA, Kiem HP, Martin PJ, Petersdorf E, Radich JP, Sanders JE, Shulman HM, Warren EH, Witherspoon RP, Bryant EM, Chauncey TR, Getzendaner L, Storb R, Appelbaum FR.
Blood. 2002 Aug 15; 4(100)1201-7
Kurre P, Morris J, Andrews RG, Kohn DB, Kiem HP.
Mol Ther. 2002 Jul; 1(6)83-90
Kiem HP, Rasko JE, Morris J, Peterson L, Kurre P, Andrews RG.
Hum Gene Ther. 2002 May 20; 8(13)891-9
Furlong T, Leisenring W, Storb R, Anasetti C, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Kiem HP, Nash RA, Sanders JE, Witherspoon R, Thompson D, Martin PJ.
Biol Blood Marrow Transplant. 2002; 4(8)206-12
Goerner M, Gooley T, Flowers ME, Sullivan KM, Kiem HP, Sanders JE, Martin PJ, Storb R.
Biol Blood Marrow Transplant. 2002; 1(8)47-56
Purton LE, Morris JC, Bernstein ID, Collins SJ, Kiem HP.
J Hematother Stem Cell Res. 2001 Dec; 6(10)815-25
Bruno B, Goerner MA, Nash RA, Storb R, Kiem HP, McSweeney PA.
Biol Blood Marrow Transplant. 2001; 10(7)543-51
Georges GE, Storb R, Bruno B, Brodie SJ, Thompson JD, Taranova AG, Zaucha JM, Little MT, Zellmer E, Moore PF, Gooley T, Sale G, Kiem HP, Sandmaier BM, Lyons RM, Nash RA.
Blood. 2001 Dec 1; 12(98)3447-55
Goerner M, Horn PA, Peterson L, Kurre P, Storb R, Rasko JE, Kiem HP.
Blood. 2001 Oct 1; 7(98)2065-70
Feinstein L, Sandmaier B, Maloney D, McSweeney PA, Maris M, Flowers C, Radich J, Little MT, Nash RA, Chauncey T, Woolfrey A, Georges G, Kiem HP, Zaucha JM, Blume KG, Shizuru J, Niederwieser D, Storb R.
Ann N Y Acad Sci. 2001 Jun; (938)328-37; discussion 337-9
Kurre P, Morris J, Horn PA, Harkey MA, Andrews RG, Kiem HP.
Mol Ther. 2001 Jun; 6(3)920-7
McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier BM, Molina AJ, Maloney DG, Chauncey TR, Gooley TA, Hegenbart U, Nash RA, Radich J, Wagner JL, Minor S, Appelbaum FR, Bensinger WI, Bryant E, Flowers ME, Georges GE, Grumet FC, Kiem HP, Torok-Storb B, Yu C, Blume KG, Storb RF.
Blood. 2001 Jun 1; 11(97)3390-400
Kurre P, Morris J, Miller AD, Kiem HP.
Gene Ther. 2001 Apr; 8(8)593-9
Progress towards hematopoietic stem cell gene therapy.
Kurre P, Kiem HP.
Curr Opin Mol Ther. 2000 Aug; 4(2)400-11
Severe canine hereditary hemolytic anemia treated by nonmyeloablative marrow transplantation.
Zaucha JA, Yu C, Lothrop CD Jr, Nash RA, Sale G, Georges G, Kiem HP, Niemeyer GP, Dufresne M, Cao Q, Storb R.
Biol Blood Marrow Transplant. 2001; 1(7)14-24
Berger C, Huang ML, Gough M, Greenberg PD, Riddell SR, Kiem HP.
J Virol. 2001 Jan; 2(75)799-808
Goerner M, Roecklein B, Torok-Storb B, Heimfeld S, Kiem HP.
J Hematother Stem Cell Res. 2000 Oct; 5(9)759-65
Highly efficient gene transfer into preterm CD34 hematopoietic progenitor cells.
Shields LE, Kiem HP, Andrews RG.
Am J Obstet Gynecol. 2000 Sep; 3(183)732-7
Andrews RG, Peterson LJ, Morris J, Potter J, Heyward S, Gough M, Bryant E, Kiem HP.
Exp Hematol. 2000 May; 5(28)508-18
Berger C, Xuereb S, Johnson DC, Watanabe KS, Kiem HP, Greenberg PD, Riddell SR.
J Virol. 2000 May; 10(74)4465-73
Storb R, Yu C, Zaucha JM, Deeg HJ, Georges G, Kiem HP, Nash RA, McSweeney PA, Wagner JL.
Blood. 1999 Oct 1; 7(94)2523-9
Goerner M, Bruno B, McSweeney PA, Buron G, Storb R, Kiem HP.
Blood. 1999 Oct 1; 7(94)2287-92
Kiem HP, McSweeney PA, Bruno B, Goerner M, Buron G, Morris J, Storb R, Miller AD.
Gene Ther. 1999 Jun; 6(6)966-72
Storb R, Yu C, Barnett T, Wagner JL, Deeg HJ, Nash RA, Kiem HP, McSweeney P, Seidel K, Georges G, Zaucha JM.
Blood. 1999 Aug 1; 3(94)1131-6
Gene transfer into fetal baboon hematopoietic progenitor cells.
Winkler A, Kiem HP, Shields LE, Sun QH, Andrews RG.
Hum Gene Ther. 1999 Mar 1; 4(10)667-77
Kurre P, Kiem HP, Morris J, Heyward S, Battini JL, Miller AD.
J Virol. 1999 Jan; 1(73)495-500
Georges GE, Storb R, Brunvand MW, Kiem HP, Moore PF, Malik P, Ennist D, Nash RA.
Transplantation. 1998 Aug 27; 4(66)540-4
Kiem HP, Andrews RG, Morris J, Peterson L, Heyward S, Allen JM, Rasko JE, Potter J, Miller AD.
Blood. 1998 Sep 15; 6(92)1878-86
Current and future preparative regimens for bone marrow transplantation in thalassemia.
Storb R, Yu C, Deeg HJ, Georges G, Kiem HP, Mcsweeney PA, Nash RA, Sandmaier BM, Sullivan KM, Wagner JL, Walters MC.
Ann N Y Acad Sci. 1998 Jun 30; (850)276-87
Glimm H, Flügge K, Möbest D, Hofmann VM, Postmus J, Henschler R, Lange W, Finke J, Kiem HP, Schulz G, Rosenthal F, Mertelsmann R, von Kalle C.
Hum Gene Ther. 1998 Apr 10; 6(9)771-8
Schuening F, Longo WL, Atkinson ME, Zaboikin M, Kiem HP, Sanders J, Scott CR, Storb R, Miller AD, Reynolds T, Bensinger W, Rowley S, Gooley T, Darovsky B, Appelbaum F.
Hum Gene Ther. 1997 Nov 20; 17(8)2143-60
Glimm H, Kiem HP, Darovsky B, Storb R, Wolf J, Diehl V, Mertelsmann R, Von Kalle C.
Hum Gene Ther. 1997 Nov 20; 17(8)2079-86
Kiem HP, Heyward S, Winkler A, Potter J, Allen JM, Miller AD, Andrews RG.
Blood. 1997 Dec 1; 11(90)4638-45
Schuening FG, von Kalle C, Kiem HP, Appelbaum FR, Deeg HJ, Pepe M, Gooley T, Graham TC, Hackman RC, Storb R.
Exp Hematol. 1997 Nov; 12(25)1240-5
GaLV pseudotyped vectors and cationic lipids transduce human CD34+ cells.
Dybing J, Lynch CM, Hara P, Jurus L, Kiem HP, Anklesaria P.
Hum Gene Ther. 1997 Sep 20; 14(8)1685-94
Hepatitis-associated aplastic anemia.
Kiem HP, Storb R, McDonald GB.
N Engl J Med. 1997 Aug 7; 6(337)424-5
Prevalence of hepatitis G virus in patients with aplastic anemia.
Kiem HP, Myerson D, Storb R, McDonald GB, Spurgeon CL, Leisenring W.
Blood. 1997 Aug 1; 3(90)1335-6
Storb R, Yu C, Wagner JL, Deeg HJ, Nash RA, Kiem HP, Leisenring W, Shulman H.
Blood. 1997 Apr 15; 8(89)3048-54
Human CD34+ cells do not express glutathione S-transferases alpha.
Czerwinski M, Kiem HP, Slattery JT.
Gene Ther. 1997 Mar; 3(4)268-70
Kiem HP, Leisenring W, Raff R, Deeg HJ, Schuening FG, Appelbaum FR, Storb R.
Blood. 1996 Sep 1; 5(88)1896-7
Humoral immune response limits gene therapy in canine MPS I.
Shull R, Lu X, Dubé I, Lutzko C, Kruth S, Abrams-Ogg A, Kiem HP, Goehle S, Schuening F, Millan C, Carter R.
Blood. 1996 Jul 1; 1(88)377-9
Marrow transplantation for hepatitis-associated aplastic anemia: a follow-up of long-term survivors.
Kiem HP, McDonald GB, Myerson D, Spurgeon CL, Deeg HJ, Sanders JE, Doney K, Appelbaum FR, Sullivan KM, Witherspoon RP, Storb R.
Biol Blood Marrow Transplant. 1996 May; 2(2)93-9
A novel murine retrovirus identified during testing for helper virus in human gene transfer trials.
Miller AD, Bonham L, Alfano J, Kiem HP, Reynolds T, Wolgamot G.
J Virol. 1996 Mar; 3(70)1804-9
Long-term persistence of canine hematopoietic cells genetically marked by retrovirus vectors.
Kiem HP, Darovsky B, Von Kalle C, Goehle S, Graham T, Miller AD, Storb R, Schuening FG.
Hum Gene Ther. 1996 Jan; 1(7)89-96
Development of a clonality assay for canine hematopoietic stem cells.
Wagner LA, Kiem HP, McSweeney P, Schuening FG, Storb R, Ostrander EA.
Blood. 1995 Oct 15; 8(86)3265-7
Gene therapy and bone marrow transplantation.
Kiem HP, von Kalle C, Schuening F, Storb R.
Curr Opin Oncol. 1995 Mar; 2(7)107-14
Barquinero J, Kiem HP, von Kalle C, Darovsky B, Goehle S, Graham T, Seidel K, Storb R, Schuening FG.
Blood. 1995 Mar 1; 5(85)1195-201
von Kalle C, Kiem HP, Goehle S, Darovsky B, Heimfeld S, Torok-Storb B, Storb R, Schuening FG.
Blood. 1994 Nov 1; 9(84)2890-7
Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells.
Kiem HP, Darovsky B, von Kalle C, Goehle S, Stewart D, Graham T, Hackman R, Appelbaum FR, Deeg HJ, Miller AD.
Blood. 1994 Mar 15; 6(83)1467-73
Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL.
J Exp Med. 1991 Jul 1; 1(174)139-49
Use of the polymerase chain reaction to monitor the effectiveness of ex vivo tumor cell purging.
Negrin RS, Kiem HP, Schmidt-Wolf IG, Blume KG, Cleary ML.
Blood. 1991 Feb 1; 3(77)654-60
Kiem HP, Nourse J, Saltman DL, Blume KG, Cleary ML.
Oncogene. 1990 Dec; 12(5)1815-9
Research Summary
The Kiem Lab studies cell and gene therapy with a particular interest in the biology of blood and marrow stem cells and the development and use of novel genome editing technologies. The overall goal is to develop better stem cell transplant and cell and gene therapy treatments for patients with genetic and infectious diseases and cancer.