faculty

Gabriele Varani

varani@uw.edu
Professor

University of Washington

Biophysical and Structural Biology

Cancer Biology

Small molecule inhibitors of RNA

Faculty Contact Information

Building: Begley Hall Room: 63 Box: 351700 Phone: 371-13 Alt Phone: 206-387-3707 https://depts.washington.edu/varani2/

Research Summary

We research and discover small drug-like molecules that bind to regulatory RNAs in oncogenic and tumor suppressive mRNAs, non coding RNAs and viruses. We use biophysical methods and structure-based design to improve their potency and pharmacology in Academia and through biotech spin-offs in oncology.

DEI Statement

Dr. Varani has been very actively involved in education of under-represented minorities (URMs) and has a very strong professional interest and personal commitment to education of underrepresented minorities. He has done so as a mentor to multiple undergraduate and graduate students, as member of the Faculty Advisory Board of IMSD (Initiative to Maximize Student Diversity); he is director of UW-PREP since 2011, a post-baccalaurate (PREP) program, where Dr. Varani is also the PI; he has also been a member of the Health Science Center Minority Center Advisory Board and of the Diversity Coun

Training Summary

Dr Varani has been director and PI of UW PREP, a program that bring recent URM graduates to the UW to prepare for admissionto graduate school.

https://depts.washington.edu/uwprep/

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Publications

The following publications were retrieved from PubMed:

Efficient NMR Screening Approach to Discover Small Molecule Fragments Binding Structured RNA.

Shortridge MD, Varani G.

ACS Med Chem Lett. 2021 Aug 12; 8(12)1253-1260

Decision making based on hybrid modeling approach applied to cellulose acetate based historical films conservation.

Al Mohtar A, Pinto ML, Neves A, Nunes S, Zappi D, Varani G, Ramos AM, Melo MJ, Wallaszkovits N, Lahoz Rodrigo JI, Herlt K, Lopes J.

Sci Rep. 2021 Aug 9; 1(11)16074

High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device.

Marrella A, Fedi A, Varani G, Vaccari I, Fato M, Firpo G, Guida P, Aceto N, Scaglione S.

PLoS One. 2021; 1(16)e0245536

Quantum dots functionalised artificial peptides bioinspired to the D1 protein from the Photosystem II of Chlamydomonas reinhardtii for endocrine disruptor optosensing.

Giardi MT, Zappi D, Turemis M, Varani G, Lo Celso F, Barone G, Calandra P, Antonacci A, Scognamiglio V.

Talanta. 2021 Mar 1; (224)121854

High-Tech and Nature-Made Nanocomposites and Their Applications in the Field of Sensors and Biosensors for Gas Detection.

Zappi D, Ramma MM, Scognamiglio V, Antonacci A, Varani G, Giardi MT.

Biosensors (Basel). 2020 Nov 13; 11(10)



PubMed Collection Link

Accepting Students For:

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Lab Information

Location: University of Washington
Building: Begley
Room: 63
https://depts.washington.edu/varani2/