faculty

Don Sodora

Donald.Sodora@Seattlechildrens.org
Professor

Seattle Childrens Research Institute

Microbiology, Infection & Immunity

Understanding viral transmission and virus-associated disease

Faculty Contact Information

Building: 307 WESTLAKE AVENUE N, SUITE 500 Box: Office # 420 Phone: 206-884-3221 https://www.seattlechildrens.org/directory/don-sodora/

Research Summary

Work in the Sodora Lab primarily focuses on two principal areas of research: how viruses are transmitted from one host to another, and viral/immune interactions that result in disease and death. Our efforts are focused on evaluating diseases caused by HIV (often utilizing the SIV animal model) as well as the SARS-CoV-2 virus. Collectively, these research strategies are designed to produce novel vaccine approaches and immune therapies that will decrease the spread of these viruses as well as preventing disease progression in infected people.

DEI Statement

Diverse laboratory environments are essential to foster the exchange of ideas, critical inquiry, creative exploration and optimum productivity. Dr. Sodora promotes an anti-racist environment in his laboratory with the goal of dismantling the systemic racism, homophobia and sexism that excludes so many from academic participation.

Training Summary

Dr. Sodora strives to be an excellent mentor to everyone in his laboratory irrespective of their job title, race, creed, sexual orientation, or sex. The laboratory personnel have met once in August 2021 with more meetings planned in the future to discuss how we all can promote anti-racism. Currently there are two URM working in the Sodora laboratory and being mentored by Dr. Sodora, one is an undergrad intern and the other is a research technician.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_614df133b5e7683bf564eae8&retmode=json
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["sorttitle"]=> string(120) "contribution of cysteine residues to antigenicity and extent of processing of herpes simplex virus type 1 glycoprotein d" ["volume"]=> string(2) "62" ["issue"]=> string(1) "6" ["pages"]=> string(6) "1941-7" ["lang"]=> array(1) { [0]=> string(3) "eng" } ["nlmuniqueid"]=> string(7) "0113724" ["issn"]=> string(9) "0022-538X" ["essn"]=> string(9) "1098-5514" ["pubtype"]=> array(1) { [0]=> string(15) "Journal Article" } ["recordstatus"]=> string(28) "PubMed - indexed for MEDLINE" ["pubstatus"]=> string(1) "4" ["articleids"]=> array(6) { [0]=> array(3) { ["idtype"]=> string(6) "pubmed" ["idtypen"]=> int(1) ["value"]=> string(7) "2835498" } [1]=> array(3) { ["idtype"]=> string(3) "pmc" ["idtypen"]=> int(8) ["value"]=> string(9) "PMC253277" } [2]=> array(3) { ["idtype"]=> string(3) "doi" ["idtypen"]=> int(3) ["value"]=> string(31) "10.1128/JVI.62.6.1941-1947.1988" } [3]=> array(3) { ["idtype"]=> string(3) "rid" ["idtypen"]=> int(8) ["value"]=> string(7) "2835498" } [4]=> array(3) { ["idtype"]=> string(3) "eid" ["idtypen"]=> int(8) ["value"]=> string(7) "2835498" } [5]=> array(3) { ["idtype"]=> string(5) "pmcid" ["idtypen"]=> int(5) ["value"]=> string(18) "pmc-id: PMC253277;" } } ["history"]=> array(3) { [0]=> array(2) { ["pubstatus"]=> string(6) "pubmed" ["date"]=> string(16) "1988/06/01 00:00" } [1]=> array(2) { ["pubstatus"]=> string(7) "medline" ["date"]=> string(16) "1988/06/01 00:01" } [2]=> array(2) { ["pubstatus"]=> string(6) "entrez" ["date"]=> string(16) "1988/06/01 00:00" } } ["references"]=> array(0) { } ["attributes"]=> array(1) { [0]=> string(12) "Has Abstract" } ["pmcrefcount"]=> int(22) ["fulljournalname"]=> string(19) "Journal of virology" ["elocationid"]=> string(0) "" ["doctype"]=> string(8) "citation" ["srccontriblist"]=> array(0) { } ["booktitle"]=> string(0) "" ["medium"]=> string(0) "" ["edition"]=> string(0) "" ["publisherlocation"]=> string(0) "" ["publishername"]=> string(0) "" ["srcdate"]=> string(0) "" ["reportnumber"]=> string(0) "" ["availablefromurl"]=> string(0) "" ["locationlabel"]=> string(0) "" ["doccontriblist"]=> array(0) { } ["docdate"]=> string(0) "" ["bookname"]=> string(0) "" ["chapter"]=> string(0) "" ["sortpubdate"]=> string(16) "1988/06/01 00:00" ["sortfirstauthor"]=> string(9) "Wilcox WC" ["vernaculartitle"]=> string(0) "" } [2452897]=> array(43) { ["uid"]=> string(7) "2452897" ["pubdate"]=> string(8) "1988 Jun" ["epubdate"]=> string(0) "" ["source"]=> string(7) "J Virol" ["authors"]=> array(6) { [0]=> array(3) { ["name"]=> string(8) "Cohen GH" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [1]=> array(3) { ["name"]=> string(9) "Wilcox WC" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [2]=> array(3) { ["name"]=> string(9) "Sodora DL" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [3]=> array(3) { ["name"]=> string(6) "Long D" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [4]=> array(3) { ["name"]=> string(8) "Levin JZ" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } [5]=> array(3) { ["name"]=> string(12) "Eisenberg RJ" ["authtype"]=> string(6) "Author" ["clusterid"]=> string(0) "" } } ["lastauthor"]=> string(12) "Eisenberg RJ" ["title"]=> string(93) "Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cells." 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Publications

The following publications were retrieved from PubMed:

Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.

Wood MP, Jones CI, Lippy A, Oliver BG, Walund B, Fancher KA, Fisher BS, Wright PJ, Fuller JT, Murapa P, Habib J, Mavigner M, Chahroudi A, Sather DN, Fuller DH, Sodora DL.

PLoS Pathog. 2021 May; 5(17)e1009575

Maternal HIV status skews transcriptomic response in infant cord blood monocytes exposed to Bacillus Calmette--Guerín.

Jones CI, Rose SL, Shutt A, Cairo C, Bourgeois NM, Charurat M, Sodora DL, Wood MP.

AIDS. 2021 Jan 1; 1(35)23-32

Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates.

Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN.

PLoS One. 2020; 5(15)e0233577

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

J Virol. 2020 Mar 31; 8(94)

Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.

Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL.

J Infect Dis. 2020 Jun 16; 1(222)44-53

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Lab Information

Location: Seattle Children's Research Institute, Center for Global Infectious Disease Research
Building: 307 Westlake Ave N,
Room: 4th floor
Phone: 206-884-3221