faculty

Peter Nelson

pnelson@fhcrc.org

Fred Hutch, 

Cancer Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Genetics and Genomics of Cancer

Faculty Contact Information

Building: Thomas Room: D4-109 Box: D4-100 Phone: 206-667-3377

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Thomas Building Room: D4-100 Box: D4-100 Phone: 206-667-3498 Alt Phone: 206-667-3377

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer.

Li S, Fong KW, Gritsina G, Zhang A, Zhao JC, Kim J, Sharp A, Yuan W, Aversa C, Yang XJ, Nelson PS, Feng FY, Chinnaiyan AM, de Bono JS, Morrissey C, Rettig MB, Yu J.

Cancer Res. 2019 Apr 5;

Association of prostate cancer SLCO gene expression with Gleason grade and alterations following androgen deprivation therapy.

Alsinnawi M, Zhang A, Bianchi-Frias D, Burns J, Cho E, Zhang X, Sowalsky A, Ye H, Slee AE, True L, Porter C, Taplin ME, Balk S, Nelson PS, Montgomery RB, Mostaghel EA.

Prostate Cancer Prostatic Dis. 2019 Mar 19;

Clinical determinants for successful circulating tumor DNA analysis in prostate cancer.

Schweizer MT, Gulati R, Beightol M, Konnick EQ, Cheng HH, Klemfuss N, De Sarkar N, Yu EY, Montgomery RB, Nelson PS, Pritchard CC.

Prostate. 2019 May; 7(79)701-708

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer.

Cato L, de Tribolet-Hardy J, Lee I, Rottenberg JT, Coleman I, Melchers D, Houtman R, Xiao T, Li W, Uo T, Sun S, Kuznik NC, Göppert B, Ozgun F, van Royen ME, Houtsmuller AB, Vadhi R, Rao PK, Li L, Balk SP, Den RB, Trock BJ, Karnes RJ, Jenkins RB, Klein EA, Davicioni E, Gruhl FJ, Long HW, Liu XS, Cato ACB, Lack NA, Nelson PS, Plymate SR, Groner AC, Brown M.

Cancer Cell. 2019 Mar 18; 3(35)401-413.e6

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis.

Zhao Y, Ding L, Wang D, Ye Z, He Y, Ma L, Zhu R, Pan Y, Wu Q, Pang K, Hou X, Weroha SJ, Han C, Coleman R, Coleman I, Karnes RJ, Zhang J, Nelson PS, Wang L, Huang H.

EMBO J. 2019 Mar 1; 5(38)

Research Summary

We study several inter-related aspects of cancer biology. We seek to identify and understand the role of key somatic genomic alterations that drive cancer development, metastasis (with organ tropism), and therapy resistance. A second area of focus involves determining influences of the tumor microenvironment on cancer cell behavior. A third area of focus centers on determining the roles of hormones and nuclear hormone receptors as lineage oncogenes, with a particular emphasis on cancer of the prostate, the most common cancer affecting men.