faculty

Olivia Bermingham-McDonogh

oliviab@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Neuroscience (Area Director)

Development and regeneration of sensory structures in the inner ear

Faculty Contact Information

Building: Health Sciences Room: I-534 Box: 357420 Phone: 206-616-4652

Lab Information

Location: University of Washington Building: Health Sciences I wing Room: I-534 Box: 357420 Phone: 206-616-4652 Alt Phone: 206-221-0605

Accepting Students For:

Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice.

Wilkerson BA, Artoni F, Lea C, Ritchie K, Ray CA, Bermingham-McDonogh O.

J Assoc Res Otolaryngol. 2018 Oct; 5(19)483-491

Molecular Anatomy of the Developing Human Retina.

Hoshino A, Ratnapriya R, Brooks MJ, Chaitankar V, Wilken MS, Zhang C, Starostik MR, Gieser L, La Torre A, Nishio M, Bates O, Walton A, Bermingham-McDonogh O, Glass IA, Wong ROL, Swaroop A, Reh TA.

Dev Cell. 2017 Dec 18; 6(43)763-779.e4

A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.

Ueki Y, Wilken MS, Cox KE, Chipman LB, Bermingham-McDonogh O, Reh TA.

Development. 2015 Feb 1; 3(142)533-43

Hair cell generation by notch inhibition in the adult mammalian cristae.

Slowik AD, Bermingham-McDonogh O.

J Assoc Res Otolaryngol. 2013 Dec; 6(14)813-28

Research Summary

My lab is interested in the factors that contribute to the normal development of the sensory structures of the inner ear. In addition we are interested in how we can stimulate regeneration after damage to hair cells. We have shown over the last decade that both the FGF and the Notch pathways are important in the development of the sensory structures. We used an in vivo ectopic expression of activated Notch to show that this alone is capable of patterning ectopic sensory structures. We have shown that inhibition of Notch leads to formation of additional hair in crista.