faculty

Olivia Bermingham-McDonogh

oliviab@uw.edu
Professor

University of Washington

, 

Biological Structure

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Neuroscience (Area Director)

Development and regeneration of sensory structures in the inner ear

Faculty Contact Information

Building: Health Sciences Room: I-534 Box: 357420 Phone: 206-616-4652 https://sites.uw.edu/oliviab/

Research Summary

My lab is interested in the factors that contribute to the normal development of the sensory structures of the inner ear. In addition we are interested in how we can stimulate regeneration after damage to hair cells. We have shown over the last decade that both the FGF and the Notch pathways are important in the development of the sensory structures. We used an in vivo ectopic expression of activated Notch to show that this alone is capable of patterning ectopic sensory structures. We have shown that inhibition of Notch leads to formation of additional hair in crista.

DEI Statement

I currently serve on the departmental DEI committee and am committed to increasing diversity in our department and school.

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Publications

The following publications were retrieved from PubMed:

Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.

Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O.

Elife. 2021 May 18; (10)

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures.

Sridhar A, Hoshino A, Finkbeiner CR, Chitsazan A, Dai L, Haugan AK, Eschenbacher KM, Jackson DL, Trapnell C, Bermingham-McDonogh O, Glass I, Reh TA.

Cell Rep. 2020 Feb 4; 5(30)1644-1659.e4

Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.

Wilkerson BA, Chitsazan AD, VandenBosch LS, Wilken MS, Reh TA, Bermingham-McDonogh O.

Sci Rep. 2019 Jun 21; 1(9)9060

Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice.

Wilkerson BA, Artoni F, Lea C, Ritchie K, Ray CA, Bermingham-McDonogh O.

J Assoc Res Otolaryngol. 2018 Oct; 5(19)483-491

Molecular Anatomy of the Developing Human Retina.

Hoshino A, Ratnapriya R, Brooks MJ, Chaitankar V, Wilken MS, Zhang C, Starostik MR, Gieser L, La Torre A, Nishio M, Bates O, Walton A, Bermingham-McDonogh O, Glass IA, Wong ROL, Swaroop A, Reh TA.

Dev Cell. 2017 Dec 18; 6(43)763-779.e4

Lab Information

Location: University of Washington
Building: Health Sciences I wing
Room: I-534
Box: 357420
Phone: 206-616-4652
Alt Phone: 206-221-0605
https://sites.uw.edu/oliviab/