Research Summary
We study neural mechanisms of sensorimotor processing in the compact nervous system of the nimble fruit fly, Drosophila. As a fly cruises through the world, her brain gathers sensory information from the external environment, which is transformed in the central nervous system, and subsequently used to guide movement and behavior. We are interested in how the nervous system implements each stage of this process— sensory coding, central integration, and motor control. To this end, we combine genetic tools with electrophysiology and 2-photon imaging to record neural activity in behaving flies.
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Publications
The following publications were retrieved from PubMed:
Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy.
Phelps JS, Hildebrand DGC, Graham BJ, Kuan AT, Thomas LA, Nguyen TM, Buhmann J, Azevedo AW, Sustar A, Agrawal S, Liu M, Shanny BL, Funke J, Tuthill JC, Lee WA.
Cell. 2021 Feb 4; 3(184)759-774.e18
A Systematic Nomenclature for the Drosophila Ventral Nerve Cord.
Court R, Namiki S, Armstrong JD, Börner J, Card G, Costa M, Dickinson M, Duch C, Korff W, Mann R, Merritt D, Murphey RK, Seeds AM, Shirangi T, Simpson JH, Truman JW, Tuthill JC, Williams DW, Shepherd D.
Neuron. 2020 Sep 23; 6(107)1071-1079.e2
Dense neuronal reconstruction through X-ray holographic nano-tomography.
Kuan AT, Phelps JS, Thomas LA, Nguyen TM, Han J, Chen CL, Azevedo AW, Tuthill JC, Funke J, Cloetens P, Pacureanu A, Lee WA.
Nat Neurosci. 2020 Dec; 12(23)1637-1643
PubMed Collection Link
