Young Kwon
ykwon7@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Mechanisms of growth and wasting
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Drosophila melanogaster as a Model of Muscle Degeneration Disorders.
Kreipke RE, Kwon YV, Shcherbata HR, Ruohola-Baker H.
Current topics in developmental biology. 2017; 121:83-109.
- PMID:
- 28057309
Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL.
Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(18):4976-81.
- PMID:
- 27091990
- PMCID:
- PMC4983807
Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N.
Developmental cell. 2015; 33(1):36-46. NIHMSID: NIHMS687903
- PMID:
- 25850671
- PMCID:
- PMC4437243
The Hippo signaling pathway interactome.
Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P, Perrimon N.
Science (New York, N.Y.). 2013; 342(6159):737-40. NIHMSID: HHMIMS559534
- PMID:
- 24114784
- PMCID:
- PMC3951131
PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data.
Sun X, Hong P, Kulkarni M, Kwon Y, Perrimon N.
Proteome science. 2013; 11(Suppl 1):S16.
- PMID:
- 24565074
- PMCID:
- PMC3908380
Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N.
Genetics. 2012; 190(3):931-40.
- PMID:
- 22174071
- PMCID:
- PMC3296255
Function of rhodopsin in temperature discrimination in Drosophila.
Shen WL, Kwon Y, Adegbola AA, Luo J, Chess A, Montell C.
Science (New York, N.Y.). 2011; 331(6022):1333-6.
- PMID:
- 21393546
False negative rates in Drosophila cell-based RNAi screens: a case study.
Booker M, Samsonova AA, Kwon Y, Flockhart I, Mohr SE, Perrimon N.
BMC genomics. 2011; 12:50.
- PMID:
- 21251254
- PMCID:
- PMC3036618
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal.
Kwon Y, Kim SH, Ronderos DS, Lee Y, Akitake B, Woodward OM, Guggino WB, Smith DP, Montell C.
Current biology : CB. 2010; 20(18):1672-8. NIHMSID: NIHMS230637
- PMID:
- 20797863
- PMCID:
- PMC2946437
Kwon Y, Shen WL, Shim HS, Montell C.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30(31):10465-71. NIHMSID: NIHMS225961
- PMID:
- 20685989
- PMCID:
- PMC3335392
Research Summary
Anything that grows eventually decays or undergoes consumption, which is known as atrophy or wasting. Thus, like growth, wasting is a fundamental biological process involved in animal development, homeostasis and aging. My lab studies the molecular, cellular and organismal mechanisms underlying wasting process using our novel fruit fly model of cachexia-like wasting. Cachexia is the wasting syndrome commonly observed in cancer patients. Additionally, we are interested in describing the signaling networks that control organ growth employing functional proteomics and Drosophila genetics.