faculty

Young Kwon

ykwon7@uw.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Maintenance, remodeling, and deterioration of tissue pattern and physiology

Faculty Contact Information

Building: Health Science Building Room: J487 Box: 357350 Phone: 206-543-6517 https://sites.google.com/uw.edu/kwon-lab/members

Lab Information

Building: Health Science Building Room: J487 Phone: 206-543-1054 https://sites.google.com/uw.edu/kwon-lab/home

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Drosophila melanogaster as a Model of Muscle Degeneration Disorders.

Kreipke RE, Kwon YV, Shcherbata HR, Ruohola-Baker H.

Current topics in developmental biology. 2017; 121:83-109.

PubMed [journal]
PMID:
28057309

Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets.

Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL.

Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(18):4976-81.

PubMed [journal]
PMID:
27091990
PMCID:
PMC4983807

Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.

Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N.

Developmental cell. 2015; 33(1):36-46. NIHMSID: NIHMS687903

PubMed [journal]
PMID:
25850671
PMCID:
PMC4437243

The Hippo signaling pathway interactome.

Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P, Perrimon N.

Science (New York, N.Y.). 2013; 342(6159):737-40. NIHMSID: HHMIMS559534

PubMed [journal]
PMID:
24114784
PMCID:
PMC3951131

PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data.

Sun X, Hong P, Kulkarni M, Kwon Y, Perrimon N.

Proteome science. 2013; 11(Suppl 1):S16.

PubMed [journal]
PMID:
24565074
PMCID:
PMC3908380

Research Summary

Developmental process shapes sophisticated adult tissue pattern. This patten is maintained over time and remodeled or deteriorated by intrinsic and extrinsic factors, which has a huge impact on the physiology of tissue and whole animal. Our overarching goal is to understand the mechanisms underlying the maintenance, remodeling, and deterioration of tissue pattern and physiology. We are particularly interested in elucidating ’tissue non-autonomous mechanisms’ affecting tissue integrity, metabolism, and malignant transformation by utilizing Drosophila genetics, cell biology, and biochemistry.