University of Washington,
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity
Coordination of the innate and adaptive immune response
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The immune system is composed of multiple innate and adaptive immune cells with distinct functional properties. Utilizing cutting-edge imaging techniques, we are now finding that these cells have non-overlapping spatial distribution properties within lymphoid and non-lymphoid tissues, forming specialized immune microenvironments. We are now studying how these tissue microenvironments influence the crosstalk and communication between different immune cells, as well as their involvement in the generation of immune responses to vaccines, and during infectious and neoplastic disease.