faculty

Jennifer Hyde

jlhyde4@uw.edu
Assistant Professor

University of Washington

Microbiology

Microbiology, Infection & Immunity

Virus-host interactions in alphavirus pathogenesis

Faculty Contact Information

Building: SLU 3.2 Room: 553 Box: 358070 Phone: 206-543-2820

Research Summary

The interferon (IFN) response is a major determinant of pathogenesis for many viruses. Not surprisingly, these viruses have evolved many and diverse mechanisms to inhibit the IFN response and its downstream effector molecules (IFN stimulated genes; ISGs). Our goal is to identify and characterize interactions between viruses and host immune molecules that contribute to the development of pathogenesis. In particular, our research is focused on understanding the role of viral RNA structure in virus-host interaction, and how viruses use RNA structure to manipulate cellular pathways.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_5f9770873e11b14be139b44a&retmode=json
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Publications

The following publications were retrieved from PubMed:

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.

Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R.

Nat Immunol. 2019 Dec; 12(20)1610-1620

The Norovirus NS3 Protein Is a Dynamic Lipid- and Microtubule-Associated Protein Involved in Viral RNA Replication.

Cotton BT, Hyde JL, Sarvestani ST, Sosnovtsev SV, Green KY, White PA, Mackenzie JM.

J Virol. 2017 Feb 1; 3(91)

The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses.

Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS.

J Virol. 2016 Oct 1; 19(90)8780-94

Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System.

Proenca-Modena JL, Hyde JL, Sesti-Costa R, Lucas T, Pinto AK, Richner JM, Gorman MJ, Lazear HM, Diamond MS.

J Virol. 2016 Jan 1; 1(90)189-205

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Lab Information

Location: University of Washington
Building: SLU
Room: 5th floor
Box: 358070
Phone: 206-543-4199