University of Washington,
Microbiology, Infection & Immunity
Virus-host interactions in alphavirus pathogenesis
Faculty Contact Information
The interferon (IFN) response is a major determinant of pathogenesis for many viruses. Not surprisingly, these viruses have evolved many and diverse mechanisms to inhibit the IFN response and its downstream effector molecules (IFN stimulated genes; ISGs). Our goal is to identify and characterize interactions between viruses and host immune molecules that contribute to the development of pathogenesis. In particular, our research is focused on understanding the role of viral RNA structure in virus-host interaction, and how viruses use RNA structure to manipulate cellular pathways.
I believe our creativity and our science is strengthened by diverse experiences and our interactions with diverse people who bring their own unique expertise and point of view. Everybody learns differently and we each have our own strengths and weaknesses. My goal as a mentor is to help trainees identify their own strengths and hurdles and develop strategies to be the best scientist they can be.
2019: University of Wisconsin CIMER mentor training – discussion and group based workshop on developing better mentoring skills, and inclusion and diversity
2020-present: UW Allies Program – as part of the Allies program we meet regularly to discuss diverse issues that trainees face including mentors/mentoring, diversity and inclusion, and harassment. Discussions about resources available to trainees as well as our role as mentors in supporting and guiding trainees through these challenges
The following publications were retrieved from PubMed:
Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R.
Elife. 2021 Aug 3; (10)
Choi R, Zhou M, Shek R, Wilson JW, Tillery L, Craig JK, Salukhe IA, Hickson SE, Kumar N, James RM, Buchko GW, Wu R, Huff S, Nguyen TT, Hurst BL, Cherry S, Barrett LK, Hyde JL, Van Voorhis WC.
PLoS One. 2021; 4(16)e0250019
Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R.
Nat Immunol. 2019 Dec; 12(20)1610-1620
Cotton BT, Hyde JL, Sarvestani ST, Sosnovtsev SV, Green KY, White PA, Mackenzie JM.
J Virol. 2017 Feb 1; 3(91)
Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS.
J Virol. 2016 Oct 1; 19(90)8780-94
O'Donnell TB, Hyde JL, Mintern JD, Mackenzie JM.
Virology. 2016 May; (492)130-9
Proenca-Modena JL, Hyde JL, Sesti-Costa R, Lucas T, Pinto AK, Richner JM, Gorman MJ, Lazear HM, Diamond MS.
J Virol. 2016 Jan 1; 1(90)189-205
Proenca-Modena JL, Sesti-Costa R, Pinto AK, Richner JM, Lazear HM, Lucas T, Hyde JL, Diamond MS.
J Virol. 2015 May; 9(89)4720-37
Hyde JL, Diamond MS.
Virology. 2015 May; (479-480)66-74
Hyde JL, Chen R, Trobaugh DW, Diamond MS, Weaver SC, Klimstra WB, Wilusz J.
Virus Res. 2015 Aug 3; (206)99-107
Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS.
Science. 2014 Feb 14; 6172(343)783-7
Hyde JL, Gillespie LK, Mackenzie JM.
J Virol. 2012 Apr; 8(86)4110-22
Hyde JL, Mackenzie JM.
Virology. 2010 Oct 10; 1(406)138-48
Hyde JL, Sosnovtsev SV, Green KY, Wobus C, Virgin HW, Mackenzie JM.
J Virol. 2009 Oct; 19(83)9709-19
PubMed Collection Link