David Shechner


University of Washington, 

Biophysical and Structural Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Noncoding RNAs and the molecular basis of mammalian nuclear architecture

Faculty Contact Information

Building: Health Sciences Center Room: K 335A Box: 357750 Phone: 206-543-0776 Alt Phone: 617-823-4043 https://depts.washington.edu/phcol/faculty/shechner.php

Lab Information

Location: Health Sciences Center Building: K Wing Room: K 554

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Research Summary

My laboratory aims to decipher the molecular mechanisms by which mammalian cells establish and utilize higher-order chromatin structures, with an emphasis on the interplay between noncoding RNAs (ncRNAs) and nuclear architecture. Using our suite of newly developed technologies for probing and manipulating ncRNA function in situ—combined with an array of biochemical, genomic, and chemical biological approaches—we aim to elucidate the mechanisms by which ncRNAs influence nuclear organization at all levels. We believe this will enable new routes towards novel biotechnologies and therapeutics.