faculty

Paul Nghiem

pnghiem@uw.edu

University of Washington, 

Cancer Biology

Microbiology, Infection & Immunity

Immunobiology & Immune Therapy for Merkel cell carcinoma

Faculty Contact Information

Building: Brotman / SLU Room: Room 240 Box: 358050 Phone: 206-221-2632 http://pnlab.org/

Lab Information

Location: University of Washington Building: Brotman Room: Room 242 Box: 358050 Phone: 206-221-4594 http://pnlab.org/

Accepting Students For:

Rotation, Summer
Permanent

Publications

The following publications were retrieved from PubMed:

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy.

Miller NJ, Church CD, Fling SP, Kulikauskas R, Ramchurren N, Shinohara MM, Kluger HM, Bhatia S, Lundgren L, Cheever MA, Topalian SL, Nghiem P.

J Immunother Cancer. 2018 Nov 27; 1(6)131

Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab.

Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM.

J Immunother Cancer. 2018 Oct 1; 1(6)99

Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma: Impact of Immunosuppression Type on Cancer-specific and Overall Survival.

Cook M, Baker K, Redman M, Lachance K, Nguyen MH, Parvathaneni U, Bhatia S, Nghiem P, Tseng YD.

Am J Clin Oncol. 2019 Jan; 1(42)82-88

Effect of Patient Immune Status on the Efficacy of Radiation Therapy and Recurrence-Free Survival Among 805 Patients With Merkel Cell Carcinoma.

Tseng YD, Nguyen MH, Baker K, Cook M, Redman M, Lachance K, Bhatia S, Liao JJ, Apisarnthanarax S, Nghiem PT, Parvathaneni U.

Int J Radiat Oncol Biol Phys. 2018 Oct 1; 2(102)330-339

Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma.

Fan K, Ritter C, Nghiem P, Blom A, Verhaegen ME, Dlugosz A, Ødum N, Woetmann A, Tothill RW, Hicks RJ, Sand M, Schrama D, Schadendorf D, Ugurel S, Becker JC.

Clin Cancer Res. 2018 Dec 1; 23(24)5873-5882

Research Summary

Merkel cell carcinoma is usually caused in part by an extremely common (typically harmless) virus that was discovered in 2008, the Merkel cell polyomavirus. Another very important cause is extensive exposure to sunlight, possibly many years earlier, and this cancer typically presents in Caucasians with a relatively light skin tone. This cancer is more likely to kill a patient than malignant melanoma. Immune therapy is proving effective in about 50% of patients.