University of Washington,
Microbiology, Infection & Immunity
Immunobiology & Immune Therapy for Merkel cell carcinoma
Faculty Contact Information
Merkel cell carcinoma is usually caused by the Merkel cell polyomavirus, with sunlight leading to some cases as well. This cancer is more likely to kill a patient than melanoma.
Our team (merkelcell.org) is actively engaged in developing novel immune therapies for this cancer, having performed studies that led to the first two FDA approvals for MCC. We are developing a therapeutic vaccine against MCPyV as well as exploring the basis for using DNA Damage Response inhibitors (such as an ATR inhibitor) to help patients who do not persistently benefit from anti-PD1.