faculty

Brian Beliveau

beliveau@uw.edu

University of Washington, 

Biophysical and Computational Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Technologies for visualizing chromosomes in 3D

Faculty Contact Information

Building: Foege South Room: 303B Box: 355065 Phone: 206-543-7254 http://www.gs.washington.edu/faculty/beliveau.htm

Lab Information

Location: University of Washington Building: Foege South Room: 303A http://beliveau.io/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues.

Kishi JY, Lapan SW, Beliveau BJ, West ER, Zhu A, Sasaki HM, Saka SK, Wang Y, Cepko CL, Yin P.

Nat Methods. 2019 Jun; 6(16)533-544

Islands of retroelements are major components of Drosophila centromeres.

Chang CH, Chavan A, Palladino J, Wei X, Martins NMC, Santinello B, Chen CC, Erceg J, Beliveau BJ, Wu CT, Larracuente AM, Mellone BG.

PLoS Biol. 2019 May; 5(17)e3000241

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling.

Nir G, Farabella I, Pérez Estrada C, Ebeling CG, Beliveau BJ, Sasaki HM, Lee SD, Nguyen SC, McCole RB, Chattoraj S, Erceg J, AlHaj Abed J, Martins NMC, Nguyen HQ, Hannan MA, Russell S, Durand NC, Rao SSP, Kishi JY, Soler-Vila P, Di Pierro M, Onuchic JN, Callahan SP, Schreiner JM, Stuckey JA, Yin P, Aiden EL, Marti-Renom MA, Wu CT.

PLoS Genet. 2018 Dec; 12(14)e1007872

OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes.

Beliveau BJ, Kishi JY, Nir G, Sasaki HM, Saka SK, Nguyen SC, Wu CT, Yin P.

Proc Natl Acad Sci U S A. 2018 Mar 6; 10(115)E2183-E2192

Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT.

Schueder F, Lara-Gutiérrez J, Beliveau BJ, Saka SK, Sasaki HM, Woehrstein JB, Strauss MT, Grabmayr H, Yin P, Jungmann R.

Nat Commun. 2017 Dec 12; 1(8)2090

Research Summary

We are interested in understanding how chromosomes are organized in the nucleus at scales ranging from chromosome territories down to individual genomic elements and how this organization affects DNA transactions such as transcription, replication, and repair. We use computational and molecular tools in combination with super-resolution and advanced quantitative microscopy to investigate the causes and consequences of 3D genome organization. We also develop enabling molecular and imaging technologies.