faculty

Brian Beliveau

beliveau@uw.edu
Assistant Professor

University of Washington

Genome Sciences

Computational Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Technologies for visualizing chromosomes in 3D

Faculty Contact Information

Building: Foege South Room: 303B Box: 355065 Phone: 206-543-7254 http://www.gs.washington.edu/faculty/beliveau.htm

Research Summary

We are interested in understanding how chromosomes are organized in the nucleus at scales ranging from chromosome territories down to individual genomic elements and how this organization affects DNA transactions such as transcription, replication, and repair. We use computational and molecular tools in combination with super-resolution and advanced quantitative microscopy to investigate the causes and consequences of 3D genome organization. We also develop enabling molecular and imaging technologies.

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Publications

The following publications were retrieved from PubMed:

3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing.

Nguyen HQ, Chattoraj S, Castillo D, Nguyen SC, Nir G, Lioutas A, Hershberg EA, Martins NMC, Reginato PL, Hannan M, Beliveau BJ, Church GM, Daugharthy ER, Marti-Renom MA, Wu CT.

Nat Methods. 2020 Aug; 8(17)822-832

Combining Qdot Nanotechnology and DNA Nanotechnology for Sensitive Single-Cell Imaging.

Zhou W, Han Y, Beliveau BJ, Gao X.

Adv Mater. 2020 Jun 16; e1908410

OligoMinerApp: a web-server application for the design of genome-scale oligonucleotide in situ hybridization probes through the flexible OligoMiner environment.

Passaro M, Martinovic M, Bevilacqua V, Hershberg EA, Rossetti G, Beliveau BJ, Bonnal RJP, Pagani M.

Nucleic Acids Res. 2020 Jul 2; W1(48)W332-W339

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin.

Lee YCG, Ogiyama Y, Martins NMC, Beliveau BJ, Acevedo D, Wu CT, Cavalli G, Karpen GH.

PLoS Genet. 2020 Mar; 3(16)e1008673

Rapid in vitro production of single-stranded DNA.

Minev D, Guerra R, Kishi JY, Smith C, Krieg E, Said K, Hornick A, Sasaki HM, Filsinger G, Beliveau BJ, Yin P, Church GM, Shih WM.

Nucleic Acids Res. 2019 Dec 16; 22(47)11956-11962

Accepting Students For:

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Permanent

Lab Information

Location: University of Washington
Building: Foege South
Room: 303A
http://beliveau.io/