University of Washington,
Biophysical and Computational Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Technologies for visualizing chromosomes in 3D
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We are interested in understanding how chromosomes are organized in the nucleus at scales ranging from chromosome territories down to individual genomic elements and how this organization affects DNA transactions such as transcription, replication, and repair. We use computational and molecular tools in combination with super-resolution and advanced quantitative microscopy to investigate the causes and consequences of 3D genome organization. We also develop enabling molecular and imaging technologies.