faculty

Paul Valdmanis

paulnv@uw.edu
Assistant Professor

University of Washington

Genome Sciences

Genetics, Genomics & Evolution

Neuroscience

Genetic and gene therapy approaches for neurodegenerative disease

Faculty Contact Information

Building: Health Sciences Building Room: J-309 Box: 357720 Phone: 206-685-3982

Research Summary

Our research focuses on identifying the genetic and molecular basis for neurodegenerative diseases such as Amyotrophic Lateral Sclerosis and Alzheimer’s disease. We have a particular interest on the role of tandem repeats and microRNAs in disease etiology. We then incorporate gene therapy approaches for safe and effective gene knockdown using recombinant adeno-associated viral vectors.

DEI Statement

The Valdmanis lab is committed to assembling and training a diverse and talented team of researchers. We strive to create an equitable and inclusive lab experience for scientists of all identities and backgrounds.

Training Summary

Dr. Valdmanis completed his PhD training in the lab of Guy Rouleau in the Department of Human Genetics at McGill University where he identified genetic variants associated with neurodegenerative disease including ALS. During his postdoctoral work in the lab of Mark Kay at Stanford University, he optimized methods to safely and efficiently reduce target genes through use of adeno-associated viral delivery of small hairpin RNAs and identified a mechanism by which small hairpin RNAs compete with endogenous microRNAs.

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Publications

The following publications were retrieved from PubMed:

Characterizing nucleotide variation and expansion dynamics in human-specific variable number tandem repeats.

Course MM, Sulovari A, Gudsnuk K, Eichler EE, Valdmanis PN.

Genome Res. 2021 Aug; 8(31)1313-1324

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease.

Monti G, Kjolby M, Jensen AMG, Allen M, Reiche J, Møller PL, Comaposada-Baró R, Zolkowski BE, Vieira C, Jørgensen MM, Holm IE, Valdmanis PN, Wellner N, Vægter CB, Lincoln SJ, Nykjær A, Ertekin-Taner N, Young JE, Nyegaard M, Andersen OM.

Acta Neuropathol Commun. 2021 Mar 16; 1(9)43

Evolution of a Human-Specific Tandem Repeat Associated with ALS.

Course MM, Gudsnuk K, Smukowski SN, Winston K, Desai N, Ross JP, Sulovari A, Bourassa CV, Spiegelman D, Couthouis J, Yu CE, Tsuang DW, Jayadev S, Kay MA, Gitler AD, Dupre N, Eichler EE, Dion PA, Rouleau GA, Valdmanis PN.

Am J Hum Genet. 2020 Sep 3; 3(107)445-460

Spastic Paraplegia 8

Meijer IA, Valdmanis PN, Rouleau GA, Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A.

1993;

Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity.

Course MM, Gudsnuk K, Desai N, Chamberlain JR, Valdmanis PN.

Mol Ther Nucleic Acids. 2020 Mar 6; (19)572-580



PubMed Collection Link

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Lab Information

Location: University of Washington
Building: Health Sciences Building
Room: J-305
Box: 357720
Phone: 206-221-8059
https://sites.google.com/view/valdmanislab