faculty

Paul Valdmanis

paulnv@uw.edu
Assistant Professor

University of Washington

Genome Sciences

Genetics, Genomics & Evolution

Neuroscience

Genetic and gene therapy approaches for neurodegenerative disease

Faculty Contact Information

Building: Health Sciences Building Room: J-309 Box: 357720 Phone: 206-685-3982

Research Summary

Our research focuses on identifying the genetic and molecular basis for neurodegenerative diseases such as Amyotrophic Lateral Sclerosis and Alzheimer’s disease. We have a particular interest on the role of microRNAs and noncoding RNAs in disease etiology. We then incorporate gene therapy approaches for safe and effective gene knockdown using recombinant adeno-associated viral vectors.

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Publications

The following publications were retrieved from PubMed:

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S.

Ann Clin Transl Neurol. 2019 Apr; 4(6)762-777

miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression.

Valdmanis PN, Kim HK, Chu K, Zhang F, Xu J, Munding EM, Shen J, Kay MA.

Nat Commun. 2018 Dec 14; 1(9)5321

Future of rAAV Gene Therapy: Platform for RNAi, Gene Editing, and Beyond.

Valdmanis PN, Kay MA.

Hum Gene Ther. 2017 Apr; 4(28)361-372

From animal models to human disease: a genetic approach for personalized medicine in ALS.

Picher-Martel V, Valdmanis PN, Gould PV, Julien JP, Dupré N.

Acta Neuropathol Commun. 2016 Jul 11; 1(4)70

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Lab Information

Location: University of Washington
Building: Health Sciences Building
Room: J-305
Box: 357720
Phone: 206-221-8059
https://sites.google.com/view/valdmanislab