faculty

Gavin Ha

gha@fredhutch.org

Fred Hutch, 

Cancer Biology

Computational Biology

Genetics, Genomics & Evolution

1100 Fairview Ave N

Faculty Contact Information

Building: Arnold Building Room: M1-B869 Box: M1-B514 Phone: 206-667-2802 https://GavinHaLab.org/

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Arnold Building

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.

Shulman DS, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway KA, Leavey PJ, Mascarenhas L, London WB, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton BD.

British journal of cancer. 2019; 120(8):869.

PubMed [journal]
PMID:
30880335
PMCID:
PMC6474275

Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease.

Hemming ML, Klega KS, Rhoades J, Ha G, Acker KE, Andersen JL, Thai E, Nag A, Thorner AR, Raut CP, George S, Crompton BD.

JCO precision oncology. 2019; 2019. NIHMSID: NIHMS1008513

PubMed [journal]
PMID:
30793095
PMCID:
PMC6380497

Tumor fraction in cell-free DNA as a biomarker in prostate cancer.

Choudhury AD, Werner L, Francini E, Wei XX, Ha G, Freeman SS, Rhoades J, Reed SC, Gydush G, Rotem D, Lo C, Taplin ME, Harshman LC, Zhang Z, O'Connor EP, Stover DG, Parsons HA, Getz G, Meyerson M, Love JC, Hahn WC, Adalsteinsson VA.

JCI insight. 2018; 3(21).

PubMed [journal]
PMID:
30385733
PMCID:
PMC6238737

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.

Shulman DS, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway KA, Leavey PJ, Mascarenhas L, London WB, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton BD.

British journal of cancer. 2018; 119(5):615-621.

PubMed [journal]
PMID:
30131550

Genetic and transcriptional evolution alters cancer cell line drug response.

Ben-David U, Siranosian B, Ha G, Tang H, Oren Y, Hinohara K, Strathdee CA, Dempster J, Lyons NJ, Burns R, Nag A, Kugener G, Cimini B, Tsvetkov P, Maruvka YE, O'Rourke R, Garrity A, Tubelli AA, Bandopadhayay P, Tsherniak A, Vazquez F, Wong B, Birger C, Ghandi M, Thorner AR, Bittker JA, Meyerson M, Getz G, Beroukhim R, Golub TR.

Nature. 2018; 560(7718):325-330. NIHMSID: NIHMS977514

PubMed [journal]
PMID:
30089904
PMCID:
PMC6522222

Research Summary

My laboratory is interested in studying the role of genomic alterations in cancer and expanding applications for precision medicine. We develop novel algorithms to identify genomic structural alterations in tumor and circulating cell-free DNA from patients with cancer. Our goals are to uncover the genetic and epigenetic mechanisms of treatment resistance, to identify blood-based genomic biomarkers, and to translate these findings and innovations to advance clinical research and precision medicine.