faculty

Valerie Daggett

daggett@uw.edu

University of Washington, 

Biophysical and Structural Biology

Computational Biology

Faculty Contact Information

Building: Foege Room: N310B Box: 355013 Phone: 206-685-7420

Lab Information

Location: University of Washington Building: Foege Room: N351A Box: 355013 Phone: 206-543-9305 http://depts.washington.edu/daglab

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.

Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M.

Proc Natl Acad Sci U S A. 2019 Jun 4; 23(116)11502-11507

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.

Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V.

Proc Natl Acad Sci U S A. 2019 Apr 30; 18(116)8895-8900

Visualizing Protein Folding and Unfolding.

Ferina J, Daggett V.

J Mol Biol. 2019 Apr 5; 8(431)1540-1564

The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity.

Bi TM, Daggett V.

Yale J Biol Med. 2018 Sep; 3(91)247-255

A Carboxylate to Amide Substitution That Switches Protein Folds.

Gianni S, McCully ME, Malagrinò F, Bonetti D, De Simone A, Brunori M, Daggett V.

Angew Chem Int Ed Engl. 2018 Sep 24; 39(57)12795-12798

Research Summary

My lab uses both experimental and computational simulation methods to explore protein dynamics, unfolding and the effects of disease-associated mutations. Many of our current projects focus on amyloid diseases.