faculty

Valerie Daggett

daggett@uw.edu

University of Washington, 

Biophysical and Structural Biology

Computational Biology

Faculty Contact Information

Building: Foege Room: N310B Box: 355013 Phone: 206-685-7420

Lab Information

Location: University of Washington Building: Foege Room: N351A Box: 355013 Phone: 206-543-9305 http://depts.washington.edu/daglab

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity.

Bi TM, Daggett V.

Yale J Biol Med. 2018 Sep; 3(91)247-255

A Carboxylate to Amide Substitution That Switches Protein Folds.

Gianni S, McCully ME, Malagrinò F, Bonetti D, De Simone A, Brunori M, Daggett V.

Angew Chem Int Ed Engl. 2018 Sep 24; 39(57)12795-12798

Molecular dynamics-derived rotamer libraries for d-amino acids within homochiral and heterochiral polypeptides.

Childers MC, Towse CL, Daggett V.

Protein Eng Des Sel. 2018 Jun 1; 6(31)191-204

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms.

Bleem A, Christiansen G, Madsen DJ, Maric H, Strømgaard K, Bryers JD, Daggett V, Meyer RL, Otzen DE.

J Mol Biol. 2018 Oct 12; 20(430)3751-3763

Research Summary

My lab uses both experimental and computational simulation methods to explore protein dynamics, unfolding and the effects of disease-associated mutations. Many of our current projects focus on amyloid diseases.