Masaoki Kawasumi
kawasumi@uw.eduUniversity of Washington,
Cancer Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Skin cancer epigenetics
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.
Calses PC, Dhillon KK, Tucker N, Chi Y, Huang JW, Kawasumi M, Nghiem P, Wang Y, Clurman BE, Jacquemont C, Gafken PR, Sugasawa K, Saijo M, Taniguchi T.
Cell Rep. 2017 Apr 4; 1(19)162-174
Paulson KG, Lewis CW, Redman MW, Simonson WT, Lisberg A, Ritter D, Morishima C, Hutchinson K, Mudgistratova L, Blom A, Iyer J, Moshiri AS, Tarabadkar ES, Carter JJ, Bhatia S, Kawasumi M, Galloway DA, Wener MH, Nghiem P.
Cancer. 2017 Apr 15; 8(123)1464-1474
Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P.
Cancer Res. 2014 Dec 15; 24(74)7534-45
Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis.
Conney AH, Lu YP, Lou YR, Kawasumi M, Nghiem P.
Front Oncol. 2013; (3)144
Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P.
Proc Natl Acad Sci U S A. 2011 Aug 16; 33(108)13716-21
Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P.
Proc Natl Acad Sci U S A. 2011 Apr 26; 17(108)6757-62
Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P.
J Invest Dermatol. 2009 Jul; 7(129)1805-15
Chemical genetics: elucidating biological systems with small-molecule compounds.
Kawasumi M, Nghiem P.
J Invest Dermatol. 2007 Jul; 7(127)1577-84
Protection from photodamage by topical application of caffeine after ultraviolet irradiation.
Koo SW, Hirakawa S, Fujii S, Kawasumi M, Nghiem P.
Br J Dermatol. 2007 May; 5(156)957-64
Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M, Nishimoto I.
J Neurosci Res. 2005 Sep 1; 5(81)720-9
A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.
Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I.
J Neurosci Res. 2005 Mar 1; 5(79)714-23
Cytoplasmic tail adaptors of Alzheimer's amyloid-beta protein precursor.
Kawasumi M, Matsuda S, Matsuoka M, Nishimoto I.
Mol Neurobiol. 2004 Oct; 2(30)185-200
Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K.
Eur J Neurosci. 2004 May; 10(19)2826-38
Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I.
J Neurochem. 2003 Jun; 6(85)1521-38
Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I.
Eur J Neurosci. 2003 Mar; 6(17)1150-8
Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, Nishimoto I.
Neurosignals. 2002 Sep-Oct; 5(11)236-50
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.
Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, Kouyama K, Terashita K, Aiso S, Lin A, Nishimoto I.
J Neurochem. 2003 Feb; 4(84)864-77
Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I.
J Neurosci. 2001 Sep 1; 17(21)6597-607
Secreted Abeta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.
Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, Kouyama K, Nishimoto I.
Biochem Biophys Res Commun. 2001 Mar 30; 2(282)548-56
Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I.
Proc Natl Acad Sci U S A. 2001 May 22; 11(98)6336-41
Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, Nishimoto I.
J Neurosci. 2001 Mar 15; 6(21)1902-10
Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.
Sudo H, Jiang H, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y, Nishimoto I.
Mol Cell Neurosci. 2000 Dec; 6(16)708-23
Nishizawa M, Kawasumi M, Fujino M, Toh-e A.
Mol Biol Cell. 1998 Sep; 9(9)2393-405
Research Summary
We take a team science approach to better understand UV skin carcinogenesis with a goal of developing novel means to inhibit skin cancer. Our research topics include: 1) Elucidate molecular mechanisms of UV skin carcinogenesis (How do cells respond to UV damage? How does caffeine prevent skin cancer?), 2) Discover novel ATR pathway inhibitors (How can we target the ATR kinase signaling pathway to modulate DNA damage responses and treat cancer?), and 3) Develop CRISPR-Cas9-based epigenome editing tools to inhibit skin cancer (How can we regulate gene expression to inhibit skin cancer?).