faculty

Masaoki Kawasumi

kawasumi@uw.edu

University of Washington, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Skin cancer epigenetics

Faculty Contact Information

Building: Brotman Building at University of Washington Medicine South Lake Union Room: D319 Box: 358050 Phone: 206-897-5456 http://depts.washington.edu/dermatol/directory/bios/kawasumi.html

Lab Information

Location: University of Washington Medicine South Lake Union Building: Brotman Building Room: D319 Box: 358050 Phone: 206-897-5440 https://kawasumilab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.

Calses PC, Dhillon KK, Tucker N, Chi Y, Huang JW, Kawasumi M, Nghiem P, Wang Y, Clurman BE, Jacquemont C, Gafken PR, Sugasawa K, Saijo M, Taniguchi T.

Cell Rep. 2017 Apr 4; 1(19)162-174

Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.

Paulson KG, Lewis CW, Redman MW, Simonson WT, Lisberg A, Ritter D, Morishima C, Hutchinson K, Mudgistratova L, Blom A, Iyer J, Moshiri AS, Tarabadkar ES, Carter JJ, Bhatia S, Kawasumi M, Galloway DA, Wener MH, Nghiem P.

Cancer. 2017 Apr 15; 8(123)1464-1474

Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P.

Cancer Res. 2014 Dec 15; 24(74)7534-45

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis.

Conney AH, Lu YP, Lou YR, Kawasumi M, Nghiem P.

Front Oncol. 2013; (3)144

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.

Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P.

Proc Natl Acad Sci U S A. 2011 Aug 16; 33(108)13716-21

Research Summary

We take a team science approach to better understand UV skin carcinogenesis with a goal of developing novel means to inhibit skin cancer. Our research topics include: 1) Elucidate molecular mechanisms of UV skin carcinogenesis (How do cells respond to UV damage? How does caffeine prevent skin cancer?), 2) Discover novel ATR pathway inhibitors (How can we target the ATR kinase signaling pathway to modulate DNA damage responses and treat cancer?), and 3) Develop CRISPR-Cas9-based epigenome editing tools to inhibit skin cancer (How can we regulate gene expression to inhibit skin cancer?).