University of Washington,
Developmental Biology, Stem Cells & Aging
Alzheimer's disease modeling with induced pluripotent stem cells
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The Young lab is interested in determining the cellular mechanisms behind genetic risk for sporadic Alzheimer’s disease (SAD). To do this we use human induced pluripotent stem cells from patients or engineered to harbor SAD genetic risk variants. We are interrogating how defects in vesicular trafficking/endocytosis and dysregulation of neuronal epigenetic networks contribute to disease.