Michael Bruchas


University of Washington, 

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution


Dissecting Neuromodulatory - GPCR Signaling In Affective Behavior

Faculty Contact Information

Building: HSB Health Sciences Room: J187a Box: 356540 Phone: 206-543-6870 http://www.bruchaslab.org/

Lab Information

Location: University of Washington Building: HSB J-Wing Room: 187a Box: J-Wing 181 Alt Phone: 206-543-6870 http://www.bruchaslab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter


The following publications were retrieved from PubMed:

Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.

Maloney SE, Rieger MA, Al-Hasani R, Bruchas MR, Wozniak DF, Dougherty JD.

Genes Brain Behav. 2019 Jun 19;

Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward.

Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL.

Neuron. 2019 Jun 5; 5(102)1088

NOP Receptor Signaling Cascades.

Parker KE, Bruchas MR.

Handb Exp Pharmacol. 2019; (254)131-139

Research Summary

Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.