Research Summary
Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.
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Publications
The following publications were retrieved from PubMed:
Imaging stress.
Bruchas MR, Simmons A.
Neurobiol Stress. 2020 Nov; (13)100228
Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics.
Zhang Y, Castro DC, Han Y, Wu Y, Guo H, Weng Z, Xue Y, Ausra J, Wang X, Li R, Wu G, Vázquez-Guardado A, Xie Y, Xie Z, Ostojich D, Peng D, Sun R, Wang B, Yu Y, Leshock JP, Qu S, Su CJ, Shen W, Hang T, Banks A, Huang Y, Radulovic J, Gutruf P, Bruchas MR, Rogers JA.
Proc Natl Acad Sci U S A. 2019 Oct 22; 43(116)21427-21437
Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.
Qazi R, Gomez AM, Castro DC, Zou Z, Sim JY, Xiong Y, Abdo J, Kim CY, Anderson A, Lohner F, Byun SH, Chul Lee B, Jang KI, Xiao J, Bruchas MR, Jeong JW.
Nat Biomed Eng. 2019 Aug; 8(3)655-669
