Michael Bruchas


University of Washington, 

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution


Dissecting Neuromodulatory - GPCR Signaling In Affective Behavior

Faculty Contact Information

Building: HSB Health Sciences Room: J187a Box: 356540 Phone: 206-543-6870 http://www.bruchaslab.org/

Lab Information

Location: University of Washington Building: HSB J-Wing Room: 187a Box: J-Wing 181 Alt Phone: 206-543-6870 http://www.bruchaslab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter


The following publications were retrieved from PubMed:

NOP Receptor Signaling Cascades.

Parker KE, Bruchas MR.

Handb Exp Pharmacol. 2019 May 14;

Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward.

Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL.

Neuron. 2019 Apr 24;

Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.

Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S.

Sci Signal. 2019 Mar 26; 574(12)

Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.

Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW 4th, McCall JG, Al-Hasani R, Bruchas MR, Morón JA.

Neuron. 2019 May 8; 3(102)564-573.e6

Research Summary

Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.