faculty

Michael Bruchas

MBRUCHAS@UW.EDU

Professor

University of Washington

Anesthesiology

Cell Signaling & Cell/Environment Interactions

Neuroscience

Dissecting Neuromodulatory - GPCR Signaling In Affective Behavior

Faculty Contact Information

Building: HSB Health Sciences Room: J187a Box: 356540 Phone: 206-543-6870 http://www.bruchaslab.org/

Research Summary

Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.

DEI Statement

My goal as a mentor is to facilitate trainees to become well rounded, curious, and highly capable scientists. My lab is composed of trainees all with different strengths and weaknesses, based in part on our background and education, but based also on our personalities and cultural influences. I work directly with each person individually to identify their needs, and then we together build on these talents, skills, and heritage to help them succeed in their field. The whole laboratory has benefited over the years due to this philosophy. My laboratory also regularly hosts a DEI Book Club.

Training Summary

Anesthesiology Departmental Training
Neuroscience Program Mentor Training (August 2021)

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Publications

The following publications were retrieved from PubMed:

Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior.

Markovic T, Pedersen CE, Massaly N, Vachez YM, Ruyle B, Murphy CA, Abiraman K, Shin JH, Garcia JJ, Yoon HJ, Alvarez VA, Bruchas MR, Creed MC, Morón JA.

Nat Neurosci. 2021 Nov; 11(24)1601-1613

An endogenous opioid circuit determines state-dependent reward consumption.

Castro DC, Oswell CS, Zhang ET, Pedersen CE, Piantadosi SC, Rossi MA, Hunker AC, Guglin A, Morón JA, Zweifel LS, Stuber GD, Bruchas MR.

Nature. 2021 Oct; 7882(598)646-651

Author Correction: Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.

Al-Hasani R, Gowrishankar R, Schmitz GP, Pedersen CE, Marcus DJ, Shirley SE, Hobbs TE, Elerding AJ, Renaud SJ, Jing M, Li Y, Alvarez VA, Lemos JC, Bruchas MR.

Nat Neurosci. 2021 Oct; 10(24)1501

Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.

Al-Hasani R, Gowrishankar R, Schmitz GP, Pedersen CE, Marcus DJ, Shirley SE, Hobbs TE, Elerding AJ, Renaud SJ, Jing M, Li Y, Alvarez VA, Lemos JC, Bruchas MR.

Nat Neurosci. 2021 Oct; 10(24)1414-1428

Where ketamine and dopamine collide.

Marcus DJ, Bruchas MR.

Elife. 2021 Jun 17; (10)

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Lab Information

Location: University of Washington
Building: HSB J-Wing
Room: 187a
Box: J-Wing 181
Alt Phone: 206-543-6870
http://www.bruchaslab.org/