Michael Bruchas
MBRUCHAS@UW.EDUUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Neuroscience
Dissecting Neuromodulatory - GPCR Signaling In Affective Behavior
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Castro DC, Bruchas MR.
Neuron. 2019 May 8; 3(102)529-552
Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward.
Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL.
Neuron. 2019 Apr 24;
Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S.
Sci Signal. 2019 Mar 26; 574(12)
Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW 4th, McCall JG, Al-Hasani R, Bruchas MR, Morón JA.
Neuron. 2019 May 8; 3(102)564-573.e6
In vivo detection of optically-evoked opioid peptide release.
Al-Hasani R, Wong JT, Mabrouk OS, McCall JG, Schmitz GP, Porter-Stransky KA, Aragona BJ, Kennedy RT, Bruchas MR.
Elife. 2018 Sep 3; (7)
Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum.
Wolfman SL, Gill DF, Bogdanic F, Long K, Al-Hasani R, McCall JG, Bruchas MR, McGehee DS.
Nat Commun. 2018 Jul 13; 1(9)2710
Endogenous and Exogenous Opioids in Pain.
Corder G, Castro DC, Bruchas MR, Scherrer G.
Annu Rev Neurosci. 2018 Jul 8; (41)453-473
Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.
Mulvey B, Bhatti DL, Gyawali S, Lake AM, Kriaucionis S, Ford CP, Bruchas MR, Heintz N, Dougherty JD.
Cell Rep. 2018 May 22; 8(23)2225-2235
Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.
Munanairi A, Liu XY, Barry DM, Yang Q, Yin JB, Jin H, Li H, Meng QT, Peng JH, Wu ZY, Yin J, Zhou XY, Wan L, Mo P, Kim S, Huo FQ, Jeffry J, Li YQ, Bardoni R, Bruchas MR, Chen ZF.
Cell Rep. 2018 Apr 17; 3(23)866-877
Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders.
Seo DO, Motard LE, Bruchas MR.
Neurobiol Learn Mem. 2018 Mar 14;
Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain.
Lu L, Gutruf P, Xia L, Bhatti DL, Wang X, Vazquez-Guardado A, Ning X, Shen X, Sang T, Ma R, Pakeltis G, Sobczak G, Zhang H, Seo DO, Xue M, Yin L, Chanda D, Sheng X, Bruchas MR, Rogers JA.
Proc Natl Acad Sci U S A. 2018 Feb 13; 7(115)E1374-E1383
Tuning Biased GPCR Signaling for Physiological Gain.
Spangler S, Bruchas MR.
Cell. 2017 Nov 16; 5(171)989-991
Bauer AQ, Kraft AW, Baxter GA, Wright PW, Reisman MD, Bice AR, Park JJ, Bruchas MR, Snyder AZ, Lee JM, Culver JP.
Cereb Cortex. 2018 Jan 1; 1(28)370-386
Sheahan TD, Siuda ER, Bruchas MR, Shepherd AJ, Mohapatra DP, Gereau RW 4th, Golden JP.
Neurobiol Pain. 2017 Aug-Dec; (2)1-12
Polymorphic computation in locus coeruleus networks.
Seo DO, Bruchas MR.
Nat Neurosci. 2017 Oct 26; 11(20)1517-1519
A Molecular Code for Imprinting Drug-Cue Associations.
Gomez AM, Bruchas MR.
Neuron. 2017 Sep 27; 1(96)3-5
Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior.
McCall JG, Siuda ER, Bhatti DL, Lawson LA, McElligott ZA, Stuber GD, Bruchas MR.
Elife. 2017 Jul 14; (6)
Dorsal-CA1 Hippocampal Neuronal Ensembles Encode Nicotine-Reward Contextual Associations.
Xia L, Nygard SK, Sobczak GG, Hourguettes NJ, Bruchas MR.
Cell Rep. 2017 Jun 6; 10(19)2143-2156
Samineni VK, Grajales-Reyes JG, Copits BA, O'Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RW 4th.
eNeuro. 2017 Mar-Apr; 2(4)
Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish.
Chen J, Xia L, Bruchas MR, Solnica-Krezel L.
Dev Biol. 2017 Oct 15; 2(430)385-396
Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW 4th, Ha JS, Bruchas MR, Rogers JA.
Neuron. 2017 Feb 8; 3(93)509-521.e3
McCall JG, Qazi R, Shin G, Li S, Ikram MH, Jang KI, Liu Y, Al-Hasani R, Bruchas MR, Jeong JW, Rogers JA.
Nat Protoc. 2017 Feb; 2(12)219-237
Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.
Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA.
Proc Natl Acad Sci U S A. 2016 Dec 13; 50(113)E8169-E8177
Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits.
Spangler SM, Bruchas MR.
Curr Opin Pharmacol. 2017 Feb; (32)56-70
Seo DO, Funderburk SC, Bhatti DL, Motard LE, Newbold D, Girven KS, McCall JG, Krashes M, Sparta DR, Bruchas MR.
J Neurosci. 2016 Oct 19; 42(36)10831-10842
Nygard SK, Hourguettes NJ, Sobczak GG, Carlezon WA, Bruchas MR.
J Neurosci. 2016 Sep 21; 38(36)9937-48
Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.
Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL.
Cell Rep. 2016 Mar 29; 12(14)2774-83
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT.
Pharmacol Rev. 2016 Apr; 2(68)419-57
New Technologies for Elucidating Opioid Receptor Function.
Bruchas MR, Roth BL.
Trends Pharmacol Sci. 2016 Apr; 4(37)279-289
Siuda ER, Al-Hasani R, McCall JG, Bhatti DL, Bruchas MR.
Neuropsychopharmacology. 2016 Jul; 8(41)2011-23
Architectural Representation of Valence in the Limbic System.
Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM.
Neuropsychopharmacology. 2016 Jun; 7(41)1697-715
Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.
Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW 4th, Rogers JA.
Nat Biotechnol. 2015 Dec; 12(33)1280-1286
Gupte RP, Kadunganattil S, Shepherd AJ, Merrill R, Planer W, Bruchas MR, Strack S, Mohapatra DP.
Neuropharmacology. 2016 Feb; (101)291-308
Optodynamic simulation of β-adrenergic receptor signalling.
Siuda ER, McCall JG, Al-Hasani R, Shin G, Il Park S, Schmidt MJ, Anderson SL, Planer WJ, Rogers JA, Bruchas MR.
Nat Commun. 2015 Sep 28; (6)8480
Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.
Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C.
J Neurosci. 2015 Sep 16; 37(35)12917-31
Chang SD, Brieaddy LE, Harvey JD, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA, Decker AM, McElhinny CJ Jr, Zhong D, Peterson EE, Navarro HA, Bruchas MR, Carroll FI.
ACS Chem Neurosci. 2015 Dec 16; 12(6)1956-64
Photo-activatable Cre recombinase regulates gene expression in vivo.
Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI.
Sci Rep. 2015 Sep 9; (5)13627
Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA.
J Neurosci. 2015 Sep 2; 35(35)12217-31
Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward.
Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR.
Neuron. 2015 Sep 2; 5(87)1063-77
Evidence of CNIH3 involvement in opioid dependence.
Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW.
Mol Psychiatry. 2016 May; 5(21)608-14
CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety.
McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR.
Neuron. 2015 Aug 5; 3(87)605-20
Park SI, Shin G, Banks A, McCall JG, Siuda ER, Schmidt MJ, Chung HU, Noh KN, Mun JG, Rhodes J, Bruchas MR, Rogers JA.
J Neural Eng. 2015 Oct; 5(12)056002-56002
Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics.
Jeong JW, McCall JG, Shin G, Zhang Y, Al-Hasani R, Kim M, Li S, Sim JY, Jang KI, Shi Y, Hong DY, Liu Y, Schmitz GP, Xia L, He Z, Gamble P, Ray WZ, Huang Y, Bruchas MR, Rogers JA.
Cell. 2015 Jul 30; 3(162)662-74
Chang SD, Mascarella SW, Spangler SM, Gurevich VV, Navarro HA, Carroll FI, Bruchas MR.
Mol Pharmacol. 2015 Sep; 3(88)502-11
Model Organisms in G Protein-Coupled Receptor Research.
Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR.
Mol Pharmacol. 2015 Sep; 3(88)596-603
van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ.
Mol Pharmacol. 2015 Sep; 3(88)589-95
Spatiotemporal control of opioid signaling and behavior.
Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR.
Neuron. 2015 May 20; 4(86)923-935
Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA.
J Neurosci. 2014 Jan 8; 2(34)527-38
Functional selectivity at GPCRs: new opportunities in psychiatric drug discovery.
Chang SD, Bruchas MR.
Neuropsychopharmacology. 2014 Jan; 1(39)248-9
McCall JG, Kim TI, Shin G, Huang X, Jung YH, Al-Hasani R, Omenetto FG, Bruchas MR, Rogers JA.
Nat Protoc. 2013 Dec; 12(8)2413-2428
Erratum: Thermal analysis of injectable, cellular-scale optoelectronics with pulsed power.
Li Y, Shi X, Song J, Lü C, Kim TI, McCall JG, Bruchas MR, Rogers JA, Huang Y.
Proc Math Phys Eng Sci. 2013 Sep 8; 2157(469)20130398
Al-Hasani R, McCall JG, Bruchas MR.
Front Pharmacol. 2013; (4)96
Al-Hasani R, McCall JG, Foshage AM, Bruchas MR.
Neuropsychopharmacology. 2013 Nov; 12(38)2484-97
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics.
Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y, Song J, Song YM, Pao HA, Kim RH, Lu C, Lee SD, Song IS, Shin G, Al-Hasani R, Kim S, Tan MP, Huang Y, Omenetto FG, Rogers JA, Bruchas MR.
Science. 2013 Apr 12; 6129(340)211-6
Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Chang SD, Baird MA, Cao YQ, Bruchas MR.
J Biol Chem. 2012 Dec 7; 50(287)42019-30
Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.
Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW 4th.
J Neurosci. 2012 Oct 10; 41(32)14217-26
Smith JS, Schindler AG, Martinelli E, Gustin RM, Bruchas MR, Chavkin C.
J Neurosci. 2012 Jan 25; 4(32)1488-95
Molecular mechanisms of opioid receptor-dependent signaling and behavior.
Al-Hasani R, Bruchas MR.
Anesthesiology. 2011 Dec; 6(115)1363-81
Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C.
Neuron. 2011 Aug 11; 3(71)498-511
Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C.
Proc Natl Acad Sci U S A. 2010 Dec 14; 50(107)21854-9
Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.
Melief EJ, Miyatake M, Bruchas MR, Chavkin C.
Proc Natl Acad Sci U S A. 2010 Jun 22; 25(107)11608-13
Kinase cascades and ligand-directed signaling at the kappa opioid receptor.
Bruchas MR, Chavkin C.
Psychopharmacology (Berl). 2010 Jun; 2(210)137-47
Bruchas MR, Land BB, Lemos JC, Chavkin C.
PLoS One. 2009 Dec 31; 12(4)e8528
Clayton CC, Bruchas MR, Lee ML, Chavkin C.
Mol Pharmacol. 2010 Mar; 3(77)339-47
Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C.
Proc Natl Acad Sci U S A. 2009 Nov 10; 45(106)19168-73
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.
Bruchas MR, Land BB, Chavkin C.
Brain Res. 2010 Feb 16; (1314)44-55
Bruchas MR, Xu M, Chavkin C.
Neuroreport. 2008 Sep 17; 14(19)1417-22
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C.
J Neurosci. 2008 Jan 9; 2(28)407-14
Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C.
J Neurosci. 2007 Oct 24; 43(27)11614-23
Bruchas MR, Toews ML, Bockman CS, Abel PW.
Eur J Pharmacol. 2008 Jan 14; 2-3(578)349-58
Bruchas MR, Yang T, Schreiber S, Defino M, Kwan SC, Li S, Chavkin C.
J Biol Chem. 2007 Oct 12; 41(282)29803-11
Petraschka M, Li S, Gilbert TL, Westenbroek RE, Bruchas MR, Schreiber S, Lowe J, Low MJ, Pintar JE, Chavkin C.
Neuroscience. 2007 Jun 8; 4(146)1795-807
Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C.
J Neurosci. 2007 Mar 7; 10(27)2570-81
Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses.
Li S, Lee ML, Bruchas MR, Chan GC, Storm DR, Chavkin C.
Mol Pharmacol. 2006 Nov; 5(70)1742-9
Bruchas MR, Macey TA, Lowe JD, Chavkin C.
J Biol Chem. 2006 Jun 30; 26(281)18081-9
Ippolito DL, Xu M, Bruchas MR, Wickman K, Chavkin C.
J Biol Chem. 2005 Dec 16; 50(280)41683-93
Submandibular gland acinar cells express multiple alpha1-adrenoceptor subtypes.
Bockman CS, Bruchas MR, Zeng W, O'Connell KA, Abel PW, Scofield MA, Dowd FJ.
J Pharmacol Exp Ther. 2004 Oct; 1(311)364-72
Research Summary
Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.