Research Summary
Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.
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Publications
The following publications were retrieved from PubMed:
Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.
Qazi R, Gomez AM, Castro DC, Zou Z, Sim JY, Xiong Y, Abdo J, Kim CY, Anderson A, Lohner F, Byun SH, Chul Lee B, Jang KI, Xiao J, Bruchas MR, Jeong JW.
Nat Biomed Eng. 2019 Aug; 8(3)655-669
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.
Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR.
Cell. 2019 Jul 25; 3(178)653-671.e19
