faculty

Michael Bruchas

MBRUCHAS@UW.EDU
Professor

University of Washington

Anesthesiology

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Dissecting Neuromodulatory - GPCR Signaling In Affective Behavior

Faculty Contact Information

Building: HSB Health Sciences Room: J187a Box: 356540 Phone: 206-543-6870 http://www.bruchaslab.org/

Research Summary

Molecular, cellular and system’s level dissection of neuromodulatory signaling (G-protein coupled receptor, GPCRs) within neural circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.

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Publications

The following publications were retrieved from PubMed:

Neurobiological links between stress and anxiety.

Daviu N, Bruchas MR, Moghaddam B, Sandi C, Beyeler A.

Neurobiol Stress. 2019 Nov; (11)100191

Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.

Qazi R, Gomez AM, Castro DC, Zou Z, Sim JY, Xiong Y, Abdo J, Kim CY, Anderson A, Lohner F, Byun SH, Chul Lee B, Jang KI, Xiao J, Bruchas MR, Jeong JW.

Nat Biomed Eng. 2019 Aug; 8(3)655-669

A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.

Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR.

Cell. 2019 Jul 25; 3(178)653-671.e19

Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent.

Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL.

Nucleic Acids Res. 2019 Sep 26; 17(47)e97

Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.

Maloney SE, Rieger MA, Al-Hasani R, Bruchas MR, Wozniak DF, Dougherty JD.

Genes Brain Behav. 2019 Sep; 7(18)e12593

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Lab Information

Location: University of Washington
Building: HSB J-Wing
Room: 187a
Box: J-Wing 181
Alt Phone: 206-543-6870
http://www.bruchaslab.org/