faculty

Michael Emerman

memerman@fredhutch.org
Member

Fred Hutch

Human Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

HIV replication and host antiviral genes

Faculty Contact Information

Building: Hutchinson Building Room: C2-019 Box: C2-023 Phone: 206-667-5058 http://research.fhcrc.org/emerman/en.html

Research Summary

The Emerman lab studies host-cell interactions of the human immunodeficiency virus (HIV) and related viruses. We wish to understand the molecular and evolutionary basis of virus replication and pathogenesis. We study the evolution and function of host antiviral genes in order to determine how HIV adapted to humans, and how ancient viral infections influenced the susceptibility or resistance of humans to modern lentiviruses.

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Publications

The following publications were retrieved from PubMed:

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.

Colón-Thillet R, Hsieh E, Graf L, McLaughlin RN Jr, Young JM, Kochs G, Emerman M, Malik HS.

PLoS Biol. 2019 Oct; 10(17)e3000181

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.

Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J.

PLoS Pathog. 2019 Jul; 7(15)e1007925

A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.

OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M.

Elife. 2018 Dec 6; (7)

Recurrent Loss of APOBEC3H Activity during Primate Evolution.

Garcia EI, Emerman M.

J Virol. 2018 Sep 1; 17(92)

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Lab Information

Location: Fred Htuch
Building: Hutchinson Building
Room: C2-187
Box: C2-023
Phone: 206-667-5754
http://research.fhcrc.org/emerman/en.html