Research Summary
We use mouse models and human specimens to determine how prostate epithelial lineage hierarchy is maintained, identify master regulators that control adult prostate homeostasis, characterize the identity of the cells of origin for prostate cancer, and investigate how molecular signaling, tissue microenvironment, and inflammation affect the initiation and progression of the prostate-related diseases including both benign prostatic hyperplasia and prostate cancer.
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Publications
The following publications were retrieved from PubMed:
Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.
Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.
Cell Stem Cell. 2019 May 2; 5(24)753-768.e6
