faculty

Li Xin

xin18@uw.edu
Professor

University of Washington

Genome Sciences

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Molecular and cellular mechanisms that regulate development, tissue homeostasis and carcinogenesis

Faculty Contact Information

Building: South Lake Union Room: N326 Box: 358056 Phone: 206-543-6551 https://www.washington.edu/urology/people/li-xin-ph-d/

Research Summary

We use mouse models and human specimens to determine how prostate epithelial lineage hierarchy is maintained, identify master regulators that control adult prostate homeostasis, characterize the identity of the cells of origin for prostate cancer, and investigate how molecular signaling, tissue microenvironment, and inflammation affect the initiation and progression of the prostate-related diseases including both benign prostatic hyperplasia and prostate cancer.

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Publications

The following publications were retrieved from PubMed:

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2019 May 2; 5(24)753-768.e6

Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.

Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L.

iScience. 2019 Mar 29; (13)328-338

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.

Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N.

Oncogene. 2017 Aug 17; 33(36)4767-4777

Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.

Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L.

Mol Cell. 2016 Sep 15; 6(63)976-89

The essential role of GATA transcription factors in adult murine prostate.

Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B.

Oncotarget. 2016 Jul 26; 30(7)47891-47903

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Location: University of Washington
Building: South Lake Union
Room: N320
Phone: 206-221-3495