faculty

Li Xin

xin18@uw.edu
Professor

University of Washington

Genome Sciences

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Molecular and cellular mechanisms that regulate development, tissue homeostasis and carcinogenesis

Faculty Contact Information

Building: South Lake Union Room: N326 Box: 358056 Phone: 206-543-6551 https://www.washington.edu/urology/people/li-xin-ph-d/

Research Summary

We use mouse models and human specimens to determine how prostate epithelial lineage hierarchy is maintained, identify master regulators that control adult prostate homeostasis, characterize the identity of the cells of origin for prostate cancer, and investigate how molecular signaling, tissue microenvironment, and inflammation affect the initiation and progression of the prostate-related diseases including both benign prostatic hyperplasia and prostate cancer.

DEI Statement

I believe that creating an environment where everyone, from any background, can do their best work is the right thing to do. I am passionate about creating an inclusive workplace that promotes and values diversity. A research laboratory that is diverse in age, gender identity, race, sexual orientation, physical or mental ability, ethnicity, and perspective is more productive.

Training Summary

DEI Workshop (ISCRM) – 2021

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_6391539f7d6ef0248c0543b3&retmode=json
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Publications

The following publications were retrieved from PubMed:

Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.

Jia D, Zhou Z, Kwon OJ, Zhang L, Wei X, Zhang Y, Yi M, Roudier MP, Regier MC, Dumpit R, Nelson PS, Headley M, True L, Lin DW, Morrissey C, Creighton CJ, Xin L.

Nat Commun. 2022 Nov 11; 1(13)6828

Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.

Wei X, Zhang L, Zhang Y, Cooper C, Brewer C, Tsai CF, Wang YT, Glaz M, Wessells HB, Que J, Titus MA, Cirulli V, Glaser A, Liu T, Reder NP, Creighton CJ, Xin L.

Cell Rep. 2022 Sep 6; 10(40)111313

Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer.

Coleman IM, DeSarkar N, Morrissey C, Xin L, Roudier MP, Sayar E, Li D, Corey E, Haffner MC, Nelson PS.

Clin Cancer Res. 2022 Jul 15; 14(28)3127-3140

Paracrine Wnt signaling is necessary for prostate epithelial proliferation.

Wei X, Roudier MP, Kwon OJ, Lee JD, Kong K, Dumpit R, True L, Morrissey C, Lin DW, Nelson PS, Xin L.

Prostate. 2022 Apr; 5(82)517-530

Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130.

Kwon OJ, Zhang B, Jia D, Zhang L, Wei X, Zhou Z, Liu D, Huynh KT, Zhang K, Zhang Y, Labhart P, Sboner A, Barbieri C, Haffner MC, Creighton CJ, Xin L.

Oncogene. 2022 Feb; 9(41)1309-1323

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