Research Summary
Our lab is focused on skeletal development disease and regeneration. We are understanding the genetic basis of osteoporosis, to identify new therapeutic targets to combat this massive health burden. We are also working to understand why fish are able to regenerate bony appendages following amputation, and how to mount this response in humans. The Musculoskeletal Systems Biology Lab comprises engineers, basic scientists, and clinicians. Our focus is on taking bold, innovative approaches to reverse aging-induced bone fragility, and to help realize human regenerative potential.
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Publications
The following publications were retrieved from PubMed:
Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies.
Gistelinck C, Kwon RY, Malfait F, Symoens S, Harris MP, Henke K, Hawkins MB, Fisher S, Sips P, Guillemyn B, Bek JW, Vermassen P, De Saffel H, Witten PE, Weis M, De Paepe A, Eyre DR, Willaert A, Coucke PJ.
Proc Natl Acad Sci U S A. 2018 Aug 21; 34(115)E8037-E8046
