faculty
Ronald Kwon
ronkwon@uw.edu
Associate Professor
University of Washington
Computational Biology
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Genetics, development, disease, and regeneration
Faculty Contact Information
Building: SLU/Institute for Stem Cell and Regenerative Medicine
Room: S448
Box: 358056
https://sites.uw.edu/msblgroup/
Research Summary
Our lab is focused on skeletal development disease and regeneration. We are understanding the genetic basis of osteoporosis, to identify new therapeutic targets to combat this massive health burden. We are also working to understand why fish are able to regenerate bony appendages following amputation, and how to mount this response in humans. The Musculoskeletal Systems Biology Lab comprises engineers, basic scientists, and clinicians. Our focus is on taking bold, innovative approaches to reverse aging-induced bone fragility, and to help realize human regenerative potential.
DEI Statement
We believe #BlackLivesMatter and that broad efforts are needed to address structural barriers that lead to inequality. Within our lab, we value commitment to diversity and support a non-hierarchical structure where all voices (high school student to faculty) are valued. We mentor from a belief in positive reinforcement and support for each other. Dr. Kwon is chair of the UW Faculty Council on Race, Equity, and Justice (FCREJ). He is also a member of the Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) and participates in their 1on1 mentoring program.
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Publications
The following publications were retrieved from PubMed:
Watson CJ, Tang WJ, Rojas MF, Fiedler IAK, Morfin Montes de Oca E, Cronrath AR, Callies LK, Swearer AA, Ahmed AR, Sethuraman V, Addish S, Farr GH 3rd, Gómez AE, Rai J, Monstad-Rios AT, Gardiner EM, Karasik D, Maves L, Busse B, Hsu YH, Kwon RY.
PLoS Genet. 2022 Nov; 11(18)e1010496
Tang WJ, Watson CJ, Olmstead T, Allan CH, Kwon RY.
iScience. 2022 Feb 18; 2(25)103784
Diamond KM, Rolfe SM, Kwon RY, Maga AM.
Biol Open. 2022 Feb 15; 2(11)
The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.
Troutwine BR, Gontarz P, Konjikusic MJ, Minowa R, Monstad-Rios A, Sepich DS, Kwon RY, Solnica-Krezel L, Gray RS.
Curr Biol. 2020 Jun 22; 12(30)2353-2362.e3
Phenomics-Based Quantification of CRISPR-Induced Mosaicism in Zebrafish.
Watson CJ, Monstad-Rios AT, Bhimani RM, Gistelinck C, Willaert A, Coucke P, Hsu YH, Kwon RY.
Cell Syst. 2020 Mar 25; 3(10)275-286.e5
Zebrafish: An Emerging Model for Orthopedic Research.
Busse B, Galloway JL, Gray RS, Harris MP, Kwon RY.
J Orthop Res. 2020 May; 5(38)925-936
Using zebrafish to study skeletal genomics.
Kwon RY, Watson CJ, Karasik D.
Bone. 2019 Sep; (126)37-50
Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies.
Gistelinck C, Kwon RY, Malfait F, Symoens S, Harris MP, Henke K, Hawkins MB, Fisher S, Sips P, Guillemyn B, Bek JW, Vermassen P, De Saffel H, Witten PE, Weis M, De Paepe A, Eyre DR, Willaert A, Coucke PJ.
Proc Natl Acad Sci U S A. 2018 Aug 21; 34(115)E8037-E8046
Hur M, Gistelinck CA, Huber P, Lee J, Thompson MH, Monstad-Rios AT, Watson CJ, McMenamin SK, Willaert A, Parichy DM, Coucke P, Kwon RY.
Zebrafish. 2018 Feb; 1(15)77-78
ScreenCube: A 3D Printed System for Rapid and Cost-Effective Chemical Screening in Adult Zebrafish.
Monstad-Rios AT, Watson CJ, Kwon RY.
Zebrafish. 2018 Feb; 1(15)1-8
Hur M, Gistelinck CA, Huber P, Lee J, Thompson MH, Monstad-Rios AT, Watson CJ, McMenamin SK, Willaert A, Parichy DM, Coucke P, Kwon RY.
Elife. 2017 Sep 8; (6)
Gistelinck C, Witten PE, Huysseune A, Symoens S, Malfait F, Larionova D, Simoens P, Dierick M, Van Hoorebeke L, De Paepe A, Kwon RY, Weis M, Eyre DR, Willaert A, Coucke PJ.
J Bone Miner Res. 2016 Nov; 11(31)1930-1942
A Dynamic Anesthesia System for Long-Term Imaging in Adult Zebrafish.
Wynd BM, Watson CJ, Patil K, Sanders GE, Kwon RY.
Zebrafish. 2017 Feb; 1(14)1-7
Osteogenic programs during zebrafish fin regeneration.
Watson CJ, Kwon RY.
Bonekey Rep. 2015; (4)745
Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish.
Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY.
J Bone Miner Res. 2014 Nov; 11(29)2346-56
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