faculty

John Aitchison

john.aitchison@seattlechildrens.org
Professor

Seattle Childrens Research Institute

Computational Biology

Gene Expression, Cell Cycle & Chromosome Biology

Microbiology, Infection & Immunity

Systems Cell Biology, Organelle biogenesis, and host-pathogen interactions

Faculty Contact Information

Building: Seattle Children's Research Institute, 307 Westlake Ave N Room: 5th floor Box: 307W https://www.seattlechildrens.org/directory/john-aitchison/

Research Summary

My laboratory is focused on developing and applying systems approaches to reveal systems levels insights into cell biology and infectious disease processes. We develop and build on advances in high throughput technologies and computational biology (including mass spectrometry, next generation DNA sequencing, high throughput microscopy, and integrative modeling of structures and networks) to gain fundamental insights into cell biology of organelle biogenesis and responses to infection.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_60ff787ecc59212769765fd5&retmode=json
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Publications

The following publications were retrieved from PubMed:

Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers.

Duffy FJ, Du Y, Carnes J, Epstein JE, Hoffman SL, Abdulla S, Jongo S, Mpina M, Daubenberger C, Aitchison JD, Stuart K.

Malar J. 2021 Jul 9; 1(20)308

ODELAM: Rapid Sequence-independent Detection of Drug Resistance in Mycobacterium tuberculosis Isolates.

Herricks T, Donczew M, Sherman DR, Aitchison JD.

Bio Protoc. 2021 May 20; 10(11)e4027

ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation.

Nazitto R, Amon LM, Mast FD, Aitchison JD, Aderem A, Johnson JS, Diercks AH.

J Immunol. 2021 May 24;

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2.

Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP.

bioRxiv. 2021 Apr 10;

A contained Mycobacterium tuberculosis mouse infection model predicts active disease and containment in humans.

Duffy FJ, Olson GS, Gold ES, Jahn A, Aderem A, Aitchison J, Rothchild AC, Diercks AH, Nemeth J.

J Infect Dis. 2021 Mar 10;

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