faculty

Brandon Hadland

bhadland@fredhutch.org
Assistant Member

Fred Hutch

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Developmental hematopoiesis and stem cell biology, leukemogenesis

Faculty Contact Information

Building: Thomas Room: D2-115 Box: D2-115 Phone: 206-667-1095 https://research.fhcrc.org/hadland/en.html

Research Summary

Our lab’s focus is in understanding the molecular mechanisms that orchestrate the formation of hematopoietic stem cells (HSC) during development and the signal pathways that regulate HSC fate decisions in normal and diseased states. Using mouse models, pluripotent stem cells, and in vitro engineered platforms, our goal is to unravel the dynamic intercellular interactions governing HSC genesis, and to apply this knowledge toward de novo HSC generation for the purposes of disease modelling, drug discovery, gene editing, and cellular therapies in blood and immune disorders.

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Publications

The following publications were retrieved from PubMed:

3D curvature-instructed endothelial flow response and tissue vascularization.

Mandrycky C, Hadland B, Zheng Y.

Sci Adv. 2020 Sep; 38(6)

Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo.

Kobayashi M, Tarnawsky SP, Wei H, Mishra A, Azevedo Portilho N, Wenzel P, Davis B, Wu J, Hadland B, Yoshimoto M.

Stem Cell Reports. 2019 Jul 9; 1(13)21-30

Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.

Dahlberg A, Leisenring W, Bleakley M, Meshinchi S, Baker KS, Summers C, Hadland B, Delaney C, Mallhi K, Burroughs L, Carpenter P, Woolfrey A.

Bone Marrow Transplant. 2019 Aug; 8(54)1337-1345

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.

Hadland BK, Varnum-Finney B, Nourigat-Mckay C, Flowers D, Bernstein ID.

J Vis Exp. 2018 May 8; 135

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Location: Fred Hutchinson Cancer Research Center
Building: Thomas
https://research.fhcrc.org/hadland/en.html