Research Summary
Our lab’s focus is in understanding the molecular mechanisms that orchestrate the formation of hematopoietic stem cells (HSC) during development and the signal pathways that regulate HSC fate decisions in normal and diseased states. Using mouse models, pluripotent stem cells, and in vitro engineered platforms, our goal is to unravel the dynamic intercellular interactions governing HSC genesis, and to apply this knowledge toward de novo HSC generation for the purposes of disease modelling, drug discovery, gene editing, and cellular therapies in blood and immune disorders.
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Publications
The following publications were retrieved from PubMed:
Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.
Dahlberg A, Leisenring W, Bleakley M, Meshinchi S, Baker KS, Summers C, Hadland B, Delaney C, Mallhi K, Burroughs L, Carpenter P, Woolfrey A.
Bone Marrow Transplant. 2019 Aug; 8(54)1337-1345
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II.
Nat Commun. 2018 May 8; 1(9)1828
