Research Summary
The Liachko laboratory studies neurodegenerative diseases of aging including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s disease. We use a variety of molecular biology and genetic tools, as well as model systems such as C. elegans, mammalian cultured cells, and transgenic mice. The long-term continuing goal of our research is to identify and validate new therapeutic targets to intervene in these devastating neurodegenerative diseases.
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Publications
The following publications were retrieved from PubMed:
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF.
Acta Neuropathol Commun. 2020 Nov 23; 1(8)200
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
Rojas-Prats E, Martinez-Gonzalez L, Gonzalo-Consuegra C, Liachko NF, Perez C, Ramírez D, Kraemer BC, Martin-Requero Á, Perez DI, Gil C, de Lago E, Martinez A.
Eur J Med Chem. 2021 Jan 15; (210)112968
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B.
Sci Transl Med. 2019 Dec 18; 523(11)
