faculty

Nicole Liachko

nliachko@uw.edu
Research Assistant Professor

University of Washington

Cell Signaling & Cell/Environment Interactions

Neuroscience

Genetic mechanisms of neurodegeneration

Faculty Contact Information

Box: VA GRECC S-182 Phone: 206-277-1587 https://depts.washington.edu/geront/liachko.html

Research Summary

The Liachko laboratory studies neurodegenerative diseases of aging including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s disease. We use a variety of molecular biology and genetic tools, as well as model systems such as C. elegans, mammalian cultured cells, and transgenic mice. The long-term continuing goal of our research is to identify and validate new therapeutic targets to intervene in these devastating neurodegenerative diseases.

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Publications

The following publications were retrieved from PubMed:

ARENA-based activity profiling of tau and TDP-43 transgenic C. elegans.

Currey HN, Malinkevich A, Melquist P, Liachko NF.

MicroPubl Biol. 2020 Jul 16; (2020)

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.

Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B.

Sci Transl Med. 2019 Dec 18; 523(11)

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.

Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Keene CD, Bird TD, Kraemer BC.

PLoS Genet. 2019 Dec; 12(15)e1008526

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction.

Bartoletti M, Bosco DA, Da Cruz S, Lagier-Tourenne C, Liachko N, Markmiller S, Webster KM, Wharton KA.

J Neurosci. 2019 Oct 16; 42(39)8217-8224

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.

Waldherr SM, Strovas TJ, Vadset TA, Liachko NF, Kraemer BC.

Nat Commun. 2019 Sep 30; 1(10)4443

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Lab Information

Location: Seattle VA
Building: 1
Room: 718, 721
https://sites.google.com/prod/uw.edu/liachkolab