faculty

Kevin Barry

kbarry@fredhutch.org

Assistant Professor

Fred Hutch

Cancer Biology

Microbiology, Infection & Immunity

Innate immune regulation of immune responses to cancer.

Faculty Contact Information

Building: Arnold Building Room: M5-A881 Box: M5-A864 Phone: 206-667-7811 https://www.fredhutch.org/en/faculty-lab-directory/barry-kevin.html

Research Summary

The research in our lab focuses on how a subtype of immune cells, termed innate immune cells, recognize cancer and regulate immune responses to this disease. We have identified a novel group (or axis) of innate immune cells, consisting of natural killer and dendritic cells, that mark melanoma patients who will respond to immunotherapy and have increased overall survival. In the lab we will continue to elucidate the pathways controlling innate immune responses to cancer, with a goal of generating novel therapies to boost protective immune responses to cancer.

DEI Statement

We all come into the lab with different backgrounds and experiences, giving each of us a unique way of thinking. I celebrate this uniqueness and believe that a diverse and inclusive lab environment is vital to promoting scientific creativity and progress. Given each of our unique backgrounds, I work with individuals to identify the best way to support their work to help them succeed. My goal as a mentor is to help my trainees achieve their goals and to become the best scientists that they can be. I am committed to creating a lab environment that is accepting, supportive, and values diversity.

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Publications

The following publications were retrieved from PubMed:

A framework for fibrolamellar carcinoma research and clinical trials.

Dinh TA, Utria AF, Barry KC, Ma R, Abou-Alfa GK, Gordan JD, Jaffee EM, Scott JD, Zucman-Rossi J, O'Neill AF, Furth ME, Sethupathy P.

Nat Rev Gastroenterol Hepatol. 2022 May; 5(19)328-342

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.

Mujal AM, Combes AJ, Rao AA, Binnewies M, Samad B, Tsui J, Boissonnas A, Pollack JL, Argüello RJ, Meng MV, Porten SP, Ruhland MK, Barry KC, Chan V, Krummel MF.

Cancer Immunol Res. 2022 Apr 1; 4(10)403-419

Discovering dominant tumor immune archetypes in a pan-cancer census.

Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, Immunoprofiler Consortium., Cai C, Zhan J, Davis KC, Kelley RK, Chapman JS, Atreya CE, Patel A, Daud AI, Ha P, Diaz AA, Kratz JR, Collisson EA, Fragiadakis GK, Erle DJ, Boissonnas A, Asthana S, Chan V, Krummel MF.

Cell. 2022 Jan 6; 1(185)184-203.e19

geneshot: gene-level metagenomics identifies genome islands associated with immunotherapy response.

Minot SS, Barry KC, Kasman C, Golob JL, Willis AD.

Genome Biol. 2021 May 5; 1(22)135

The Natural Killer-Dendritic Cell Immune Axis in Anti-Cancer Immunity and Immunotherapy.

Peterson EE, Barry KC.

Front Immunol. 2020; (11)621254

PubMed Collection Link

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Permanent

Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Arnold Building
https://research.fhcrc.org/barry/en.html