Microbiology, Infection & Immunity
Innate immune regulation of immune responses to cancer.
Faculty Contact Information
The research in our lab focusses on how a subtype of immune cells, termed innate immune cells, recognize cancer and regulate immune responses to this disease. We have identified a novel group (or axis) of innate immune cells, consisting of natural killer and dendritic cells, that mark melanoma patients who will respond to immunotherapy and have increased overall survival. In the lab we will continue to elucidate the pathways controlling innate immune responses to cancer, with a goal of generating novel therapies to boost protective immune responses to cancer.
The following publications were retrieved from PubMed:
Binnewies M, Mujal AM, Pollack JL, Combes AJ, Hardison EA, Barry KC, Tsui J, Ruhland MK, Kersten K, Abushawish MA, Spasic M, Giurintano JP, Chan V, Daud AI, Ha P, Ye CJ, Roberts EW, Krummel MF.
Cell. 2019 Apr 18; 3(177)556-571.e16
Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF.
Nat Med. 2018 Aug; 8(24)1178-1191
De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE.
Cell Rep. 2017 Nov 21; 8(21)2031-2038
Barry KC, Ingolia NT, Vance RE.
Elife. 2017 Apr 6; (6)
Grabiner MA, Fu Z, Wu T, Barry KC, Schwarzer C, Machen TE.
J Immunol. 2014 Aug 1; 3(193)1459-67
Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE.
J Immunol. 2013 Jun 15; 12(190)6329-39
Barry KC, Abed M, Kenyagin D, Werwie TR, Boico O, Orian A, Parkhurst SM.
Development. 2011 May; 9(138)1759-69
Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE.
PLoS Pathog. 2011 Feb; 2(7)e1001289
Abed M, Barry KC, Kenyagin D, Koltun B, Phippen TM, Delrow JJ, Parkhurst SM, Orian A.
EMBO J. 2011 Apr 6; 7(30)1289-301
Liu R, Abreu-Blanco MT, Barry KC, Linardopoulou EV, Osborn GE, Parkhurst SM.
Development. 2009 Aug; 16(136)2849-60
Kline T, Barry KC, Jackson SR, Felise HB, Nguyen HV, Miller SI.
Bioorg Med Chem Lett. 2009 Mar 1; 5(19)1340-3
Kline T, Felise HB, Barry KC, Jackson SR, Nguyen HV, Miller SI.
J Med Chem. 2008 Nov 27; 22(51)7065-74
Felise HB, Nguyen HV, Pfuetzner RA, Barry KC, Jackson SR, Blanc MP, Bronstein PA, Kline T, Miller SI.
Cell Host Microbe. 2008 Oct 16; 4(4)325-36
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Building: Arnold Building