faculty

Gaurav Bhardwaj

gauravb@uw.edu
Assistant Professor

University of Washington

Biophysical and Structural Biology

Computational Biology

Computational peptide design for targeted therapeutics

Faculty Contact Information

Building: Health Sciences Building Room: H172E Box: 357610 Phone: 206-685-3784

Research Summary

Bhardwaj Lab is developing computational and experimental tools for the high-throughput design of peptide-based therapeutics. We aim to systematically enumerate the design principles for peptides with enhanced membrane-permeability, oral bioavailability, and blood-brain barrier traversal. Current projects in the lab are focused on designing bioactive peptides against clinically-relevant molecular targets in drug resistance, chronic pain, and neurodegenerative disorders.

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Publications

The following publications were retrieved from PubMed:

Comprehensive computational design of ordered peptide macrocycles.

Hosseinzadeh P, Bhardwaj G, Mulligan VK, Shortridge MD, Craven TW, Pardo-Avila F, Rettie SA, Kim DE, Silva DA, Ibrahim YM, Webb IK, Cort JR, Adkins JN, Varani G, Baker D.

Science. 2017 Dec 15; 6369(358)1461-1466

A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel <i>in vivo</i>.

Shih TC, Liu R, Fung G, Bhardwaj G, Ghosh PM, Lam KS.

Mol Cancer Ther. 2017 Jul; 7(16)1212-1223

Accurate de novo design of hyperstable constrained peptides.

Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D.

Nature. 2016 Oct 20; 7625(538)329-335

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

Kaplan G, Lee F, Onda M, Kolyvas E, Bhardwaj G, Baker D, Pastan I.

Toxins (Basel). 2016 Jul 25; 8(8)

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Location: University of Washington
Building: Health Sciences Building
Room: H-064
Box: 357610
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