faculty

David Sherman

dsherman@uw.edu
Professor

University of Washington

Microbiology, Infection & Immunity

Gene regulatory networks and new drugs for Mycobacterium tuberculosis

Faculty Contact Information

Building: SLU F Building Room: F804 Box: F802 Phone: 206-543-8152

Research Summary

Using and developing cutting-edge systems biology approaches work in the Sherman Lab has illuminated unprecedented information in how tuberculosis senses its environment and parlays that information into an appropriate response. This work has resulted in several high-impact publications, as well as generated novel hypotheses for more effective types and combinations of antibiotics. Other Sherman lab projects are focused on the identification of novel drug targets and antibiotics.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_5f976584058f954c5204a8b6&retmode=json
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Publications

The following publications were retrieved from PubMed:

Genetic Diversity in Mycobacterium tuberculosis Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease.

Peters JS, Ismail N, Dippenaar A, Ma S, Sherman DR, Warren RM, Kana BD.

Annu Rev Genet. 2020 Sep 14;

Rapid, direct detection of bacterial topoisomerase 1-DNA adducts by RADAR/ELISA.

Sinha D, Kiianitsa K, Sherman DR, Maizels N.

Anal Biochem. 2020 Nov 1; (608)113827

Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis orn Gene Produce Reversible Ethambutol Resistance and Small-Colony-Variant Morphology.

Safi H, Lingaraju S, Ma S, Husain S, Hoque M, Soteropoulos P, Rustad T, Sherman DR, Alland D.

Antimicrob Agents Chemother. 2020 Aug 20; 9(64)

ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis.

Herricks T, Donczew M, Mast FD, Rustad T, Morrison R, Sterling TR, Sherman DR, Aitchison JD.

Elife. 2020 May 13; (9)

Reply to Vargas and Farhat: Mycobacterium tuberculosis glpK mutants in human tuberculosis.

Safi H, Sherman DR, Dick T, Alland D.

Proc Natl Acad Sci U S A. 2020 Feb 25; 8(117)3913-3914

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Lab Information

Location: University of Washington
Building: SLU F
Room: F 810
Phone: 206-616-4685
https://shermanlabuw.weebly.com/