faculty

David Sherman

dsherman@uw.edu
Professor

University of Washington

Microbiology, Infection & Immunity

Gene regulatory networks and new drugs for Mycobacterium tuberculosis

Faculty Contact Information

Building: SLU F Building Room: F804 Box: F802 Phone: 206-543-8152

Research Summary

Using and developing cutting-edge systems biology approaches work in the Sherman Lab has illuminated unprecedented information in how tuberculosis senses its environment and parlays that information into an appropriate response. This work has resulted in several high-impact publications, as well as generated novel hypotheses for more effective types and combinations of antibiotics. Other Sherman lab projects are focused on the identification of novel drug targets and antibiotics.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_638dcd84f35ccd028f115603&retmode=json
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Publications

The following publications were retrieved from PubMed:

The evolving biology of Mycobacterium tuberculosis drug resistance.

Jones RM, Adams KN, Eldesouky HE, Sherman DR.

Front Cell Infect Microbiol. 2022; (12)1027394

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains.

Lovey A, Verma S, Kaipilyawar V, Ribeiro-Rodrigues R, Husain S, Palaci M, Dietze R, Ma S, Morrison RD, Sherman DR, Ellner JJ, Salgame P.

Nat Commun. 2022 Feb 16; 1(13)884

Experimental and Computational Workflow for RNA Sequencing in Mycobacterium tuberculosis : From Total RNA to Differentially Expressed Genes.

Ma S, Jones RM Jr, Gleason NS, Farrow-Johnson J, Sherman DR.

Methods Mol Biol. 2021; (2314)481-512

ODELAM: Rapid Sequence-independent Detection of Drug Resistance in Mycobacterium tuberculosis Isolates.

Herricks T, Donczew M, Sherman DR, Aitchison JD.

Bio Protoc. 2021 May 20; 10(11)e4027

Re-evaluation of a novel resistance mutation in eccC5 of the ESX-5 secretion system in ofloxacin-resistant Mycobacterium tuberculosis.

Blackman A, Morrison B, Maruri F, van der Heijden Y, Nochowicz CH, Guo Y, Scholz M, Rustad T, Sherman DR, Sterling TR.

J Antimicrob Chemother. 2021 Feb 11; 3(76)820-822

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Lab Information

Location: University of Washington
Building: SLU F
Room: F 810
Phone: 206-616-4685
https://shermanlabuw.weebly.com/