faculty

Stanley Lee

sclee3@fredhutch.org
Assistant Professor

Fred Hutch

Cancer Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

RNA splicing in hematopoietic stem cells and malignancies

Faculty Contact Information

Building: Thomas Building Room: D4-109 Box: D4-100 Phone: 646-888-1004 https://www.fredhutch.org/en/faculty-lab-directory/lee-stanley.html

Research Summary

We are interested in understanding molecular basis of blood cell development and how dysregulation drives hematologic malignancies such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML) and bone marrow failure. In particular, we are interested in understand how somatic mutations in the RNA splicing machinery impact the biology of hematopoietic stem cells and how they drive disease progression and response to therapy. The ultimate goal of our research is to develop novel treatments for patients with blood-related disorders including leukemia.

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Publications

The following publications were retrieved from PubMed:

DNA methylation disruption reshapes the hematopoietic differentiation landscape.

Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA.

Nat Genet. 2020 Apr; 4(52)378-387

Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies.

Taylor J, Lee SC.

Genes Chromosomes Cancer. 2019 Dec; 12(58)889-902

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.

Lee SC, Miller S, Hyland C, Kauppi M, Lebois M, Di Rago L, Metcalf D, Kinkel SA, Josefsson EC, Blewitt ME, Majewski IJ, Alexander WS.

Blood. 2015 Jul 9; 2(126)167-75

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.

Sheikh BN, Lee SC, El-Saafin F, Vanyai HK, Hu Y, Pang SH, Grabow S, Strasser A, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T.

Blood. 2015 Mar 19; 12(125)1910-21

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

Lee SC, Phipson B, Hyland CD, Leong HS, Allan RS, Lun A, Hilton DJ, Nutt SL, Blewitt ME, Smyth GK, Alexander WS, Majewski IJ.

Blood. 2013 Oct 10; 15(122)2654-63

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Thomas Building
Room: D4-345
Box: D4-100
Phone: 646-888-1004
https://www.fredhutch.org/en/faculty-lab-directory/lee-stanley.html