faculty

Patrick Mitchell

psmitche@uw.edu
Assistant Professor

University of Washington

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Molecular evolution and mechanisms of host-pathogen interactions

Faculty Contact Information

Building: Microbiology, South Lake Union, 750 Republican St. Box: 358071 https://microbiology.washington.edu/users/patrick-mitchell

Research Summary

Research in the Mitchell lab is focused on understanding basic principles that govern host-pathogen interactions that influence host immunity and pathogenesis. We are particularly interested in molecular innovations born from host-pathogen evolutionary ‘arms races.’ We combine approaches from evolution, genetics, biochemistry, immunology and microbiology to decipher mechanisms that govern innate immune recognition and other host-pathogen interactions.

For more information on specific projects, please visit the lab home page!

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_6007723a07463656f26e8cc6&retmode=json
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Publications

The following publications were retrieved from PubMed:

Diverse viral proteases activate the NLRP1 inflammasome.

Tsu BV, Beierschmitt C, Ryan AP, Agarwal R, Mitchell PS, Daugherty MD.

Elife. 2021 Jan 7; (10)

NAIP-NLRC4-deficient mice are susceptible to shigellosis.

Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE.

Elife. 2020 Oct 19; (9)

Molecular characterization of a fungal gasdermin-like protein.

Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL.

Proc Natl Acad Sci U S A. 2020 Aug 4; 31(117)18600-18607

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant.

Herlin T, Jørgensen SE, Høst C, Mitchell PS, Christensen MH, Laustsen M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH.

Rheumatology (Oxford). 2020 Sep 1; 9(59)2334-2339

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.

Mitchell PS, Sandstrom A, Vance RE.

Curr Opin Immunol. 2019 Oct; (60)37-45

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