faculty

Patrick Mitchell

psmitche@uw.edu
Assistant Professor

University of Washington

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Molecular evolution and mechanisms of host-pathogen interactions

Faculty Contact Information

Building: Microbiology, South Lake Union, 750 Republican St. Room: F-840 Box: 358071 https://mitchelllabuw.com/

Research Summary

Research in the Mitchell lab is focused on understanding basic principles that govern host-pathogen interactions that influence host immunity and pathogenesis. We are particularly interested in molecular innovations born from host-pathogen evolutionary ‘arms races.’ We combine approaches from evolution, genetics, biochemistry, immunology and microbiology to decipher mechanisms that govern innate immune recognition and other host-pathogen interactions.

For more information on specific projects, please visit the lab home page!

DEI Statement

Science is for everyone: We are committed to creating an inclusive, safe, and equitable lab environment. We acknowledge that our institutions are flawed, and that working toward effectively combating racism, sexism, homophobia, transphobia, ableism, and other institutionalized and systemic oppressions is an important aspect of creating the scientific community we want to be a part of.

Dr. Mitchell serves on the Department of Microbiology diversity committee.

Training Summary

Workshop: Inclusive teaching and mentoring (2021)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_616a627c32ae3e1c3964fa2a&retmode=json
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Publications

The following publications were retrieved from PubMed:

Diverse viral proteases activate the NLRP1 inflammasome.

Tsu BV, Beierschmitt C, Ryan AP, Agarwal R, Mitchell PS, Daugherty MD.

Elife. 2021 Jan 7; (10)

NAIP-NLRC4-deficient mice are susceptible to shigellosis.

Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE.

Elife. 2020 Oct 19; (9)

Molecular characterization of a fungal gasdermin-like protein.

Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL.

Proc Natl Acad Sci U S A. 2020 Aug 4; 31(117)18600-18607

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant.

Herlin T, Jørgensen SE, Høst C, Mitchell PS, Christensen MH, Laustsen M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH.

Rheumatology (Oxford). 2020 Sep 1; 9(59)2334-2339

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.

Mitchell PS, Sandstrom A, Vance RE.

Curr Opin Immunol. 2019 Oct; (60)37-45

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Lab Information

Location: Department of Microbiology
Building: South Lake Union Campus, F building
Room: F-840
https://mitchelllabuw.com/