faculty

Alexander Meeske

meeske@uw.edu
Assistant Professor

University of Washington

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

CRISPR-Cas function and Phage-Bacteria interactions

Faculty Contact Information

Building: Microbiology, South Lake Union, 750 Republican St Room: F823 Box: 358071 Phone: 206-221-2195 https://microbiology.washington.edu/users/alexander-meeske

Research Summary

CRISPR-Cas systems are prokaryotic immune systems that provide their hosts with sequence-specific protection from foreign genetic elements like bacteriophages, plasmids, and transposons. Our lab is interested in defining mechanistic relationships between CRISPR systems, the hosts that encode them, and the phages they encounter. We use a combination of microbial genetics, high-throughput genetic screens, time-lapse microscopy, and biochemical reconstitution to better understand the diverse roles of CRISPR in the microbial world.

DEI Statement

Working on a team in any professional capacity demands empathy for our colleagues. Each of us walked a different path to our current station. No one can fully comprehend all the individual challenges faced by diverse scientists while pursuing their research careers. I will do my best to listen and learn from my trainees, and help them overcome the obstacles in their way.

Training Summary

Inclusive Teaching and Mentoring – 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_616a68b78718d623b52926c4&retmode=json
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Publications

The following publications were retrieved from PubMed:

Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations.

Hossain AA, McGinn J, Meeske AJ, Modell JW, Marraffini LA.

Cell Host Microbe. 2021 Oct 13; 10(29)1482-1495.e12

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity.

Meeske AJ, Jia N, Cassel AK, Kozlova A, Liao J, Wiedmann M, Patel DJ, Marraffini LA.

Science. 2020 Jul 3; 6499(369)54-59

SwsB and SafA Are Required for CwlJ-Dependent Spore Germination in Bacillus subtilis.

Amon JD, Yadav AK, Ramirez-Guadiana FH, Meeske AJ, Cava F, Rudner DZ.

J Bacteriol. 2020 Feb 25; 6(202)

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage.

Meeske AJ, Nakandakari-Higa S, Marraffini LA.

Nature. 2019 Jun; 7760(570)241-245

RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems.

Meeske AJ, Marraffini LA.

Mol Cell. 2018 Sep 6; 5(71)791-801.e3

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Lab Information

Location: University of Washington SLU Campus
Building: Building F
Room: F830
http://meeskelab.org/