faculty

Aude Chapuis

achapuis@fredhutch.org

Associate Professor

Fred Hutch

Cancer Biology

Microbiology, Infection & Immunity

Expert in blood stem cell transplantation and immunotherapy

Faculty Contact Information

Building: Thomas Building Box: D3-100 Phone: 206-667-4369 https://www.fredhutch.org/en/faculty-lab-directory/chapuis-aude.html

Research Summary

Dr Aude Chapuis is head of a laboratory focusing on the development a translational pipeline designed to improve T cell receptor (TCR) gene therapy. This spans target identification, generation of high-affinity TCRs, cell process methodologies to translate these constructs into effective products for patients, clinical trial development and execution, and sophisticated high dimensional immune-monitoring to maximize the information that can be derived from each treated patient. A non-exhaustive list of diseases being targeted by the lab include virally-driven tumors (targeting Merkel-cell poly

DEI Statement

We accept everybody in the lab.

Training Summary

Bias Mitigation (Fred Hutch)

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Publications

The following publications were retrieved from PubMed:

CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccination.

Ford ES, Mayer-Blackwell K, Jing L, Sholukh AM, Germain RS, Bossard EL, Xie H, Pulliam TH, Jani S, Selke S, Burrow CJ, McClurkan CL, Wald A, Holbrook MR, Eaton B, Eudy E, Murphy M, Postnikova E, Robins HS, Elyanow R, Gittelman RM, Ecsedi M, Wilcox E, Chapuis AG, Fiore-Gartland A, Koelle DM.

Res Sq. 2022 Oct 10;

An In Vivo Model of Human Macrophages in Metastatic Melanoma.

Voillet V, Berger TR, McKenna KM, Paulson KG, Tan WH, Smythe KS, Hunter DS, Valente WJ, Weaver S, Campbell JS, Kim TS, Byrd DR, Bielas JH, Pierce RH, Chapuis AG, Gottardo R, Rongvaux A.

J Immunol. 2022 Aug 1; 3(209)606-620

Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.

Lahman MC, Schmitt TM, Paulson KG, Vigneron N, Buenrostro D, Wagener FD, Voillet V, Martin L, Gottardo R, Bielas J, McElrath JM, Stirewalt DL, Pogosova-Agadjanyan EL, Yeung CC, Pierce RH, Egan DN, Bar M, Hendrie PC, Kinsella S, Vakil A, Butler J, Chaffee M, Linton J, McAfee MS, Hunter DS, Bleakley M, Rongvaux A, Van den Eynde BJ, Chapuis AG, Greenberg PD.

Sci Transl Med. 2022 Feb 9; 631(14)eabg8070

Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy.

Iovino L, Thur LA, Gnjatic S, Chapuis A, Milano F, Hill JA.

J Immunother Cancer. 2021 May; 5(9)

Quality Is King: Fundamental Insights into Tumor Antigenicity from Virus-Associated Merkel Cell Carcinoma.

Lahman MC, Paulson KG, Nghiem PT, Chapuis AG.

J Invest Dermatol. 2021 Aug; 8(141)1897-1905

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