Research Summary
We study human genetic variations and gene-regulatory mechanisms to understand the heterogeneity in immune responses against viral infections in humans. Our main interest is to identify functional variants found in the coding and non-coding regions that determine susceptibility or resistance to life-threatening viral infections including hepatitis c virus, human immunodeficiency virus West Nile virus, ZIKA, influenza, and SARS-CoV-2. We use human-genetics, biochemical and molecular biology approaches to investigate how such genetic variations can affect immune response.
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string(180) "Analysis of expressed sequence tags (EST) obtained from common carp, Cyprinus carpio L., head kidney cells after stimulation by two mitogens, lipopolysaccharide and concanavalin-A."
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Publications
The following publications were retrieved from PubMed:
Germline SAMD9L truncation variants trigger global translational repression.
Allenspach EJ, Soveg F, Finn LS, So L, Gorman JA, Rosen ABI, Skoda-Smith S, Wheeler MM, Barrow KA, Rich LM, Debley JS, Bamshad MJ, Nickerson DA, Savan R, Torgerson TR, Rawlings DJ.
J Exp Med. 2021 May 3; 5(218)
Shear stress associated with cardiopulmonary bypass induces expression of inflammatory cytokines and necroptosis in monocytes.
Tu LN, Hsieh L, Kajimoto M, Charette K, Kibiryeva N, Forero A, Hampson S, Marshall JA, O'Brien J, Scatena M, Portman MA, Savan R, Benner C, Aliseda A, Nuri M, Bittel D, Pastuzsko P, Nigam V.
JCI Insight. 2021 Jan 11; 1(6)
