faculty

Ram Savan

savanram@uw.edu

Associate Professor

University of Washington

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Genetic variation affecting antiviral responses.

Faculty Contact Information

Building: SLU E Room: 307 Box: 358059 Phone: 206-221-5141

Research Summary

We study human genetic variations and gene-regulatory mechanisms to understand the heterogeneity in immune responses against viral infections in humans. Our main interest is to identify functional variants found in the coding and non-coding regions that determine susceptibility or resistance to life-threatening viral infections including hepatitis c virus, human immunodeficiency virus West Nile virus, ZIKA, influenza, and SARS-CoV-2. We use human-genetics, biochemical and molecular biology approaches to investigate how such genetic variations can affect immune response.

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Publications

The following publications were retrieved from PubMed:

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.

Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Castro LK, Beierschmitt CM, Turcotte EA, Fay EJ, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD.

bioRxiv. 2022 Sep 22;

ADAR1 mutation causes ZBP1-dependent immunopathology.

Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A.

Nature. 2022 Jul; 7920(607)769-775

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease.

Henden AS, Koyama M, Robb RJ, Forero A, Kuns RD, Chang K, Ensbey KS, Varelias A, Kazakoff SH, Waddell N, Clouston AD, Giri R, Begun J, Blazar BR, Degli-Esposti MA, Kotenko SV, Lane SW, Bowerman KL, Savan R, Hugenholtz P, Gartlan KH, Hill GR.

Blood. 2021 Aug 26; 8(138)722-737

A Conversation with Dr. Ram Savan.

Savan R

J Interferon Cytokine Res. 2021 Aug; 8(41)307-308

RNA regulatory mechanisms that control antiviral innate immunity.

Gokhale NS, Smith JR, Van Gelder RD, Savan R.

Immunol Rev. 2021 Nov; 1(304)77-96

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Permanent

Lab Information

Location: South Lake Union
Building: SLU E building
Phone: 206-221-5141
https://ramlabuw.weebly.com/