University of Washington
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Investigating disease pathogenesis and discovering therapeutic targets in rhabdomyosarcoma
Faculty Contact Information
Our main research interest is in understanding pathogenesis of cancer using zebrafish and mammalian experimental systems. Our current research focuses on dissecting cellular and molecular mechanisms underlying the pathogenesis of pediatric rhabdomyosarcoma, in particular the key events regulating tumor differentiation, relapse and metastasis. My laboratory utilizes the strategies of chemical genetics, functional genomics and genome engineering to identify key driver events of rhabdomyosarcoma.
I have mentored trainees from diverse educational and cultural backgrounds. As a mentor, I encourage all my trainees to strive for the best they can be and be open to new ideas and challenges. I work with my students to nurture their strengths and find ways to improve upon their weaknesses in order to help them grow as scientists. I am also constantly learning from my students. They have also helped me improve my role as a mentor.
The following publications were retrieved from PubMed:
Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM.
Cell Rep. 2017 Jun 13; 11(19)2304-2318
Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM.
Proc Natl Acad Sci U S A. 2014 Apr 8; 14(111)5349-54
Chen EY, Langenau DM.
Methods Cell Biol. 2011; (105)383-402
PubMed Collection Link
Accepting Students For:
Building: Health Sciences Building