faculty

Daniel Blanco-Melo

dblancom@fredhutch.org
Assistant Professor

Fred Hutch

Computational Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Mechanisms and evolution of antiviral immune defenses

Faculty Contact Information

Building: Steam Plant Building Room: S3-105 Box: E5-110

Research Summary

We study the strategies that animal hosts have deployed throughout evolution to combat viral infections. Particularly focusing on the host response to important human viruses such as Influenza A virus and SARS-CoV-2. Additionally, we aim to understand the impact of ancient viral infections on the evolution of animal immune responses. Through the combination of molecular biology, genomics and bioinformatics, we seek to characterize and exploit our highly evolved antiviral responses, in order to enable the design of broadly acting therapeutics against current and emerging viral threats.

DEI Statement

I believe that the scientific endeavor is enriched by the inclusion of diverse backgrounds, perspectives, and opinions. However, those underrepresented in science still face many challenges that could discourage them from achieving their goals. Therefore, I am committed to build a supportive environment of trust, inclusion and belonging where people can flourish, regardless of their race, ethnicity, nationality, gender identity, sexual orientation, religion or physical ability.

Training Summary

2017: Linton-Poodry SACNAS Leadership Institute: training for underrepresented minority professionals interested in advancing their leadership of diversity, equity, and inclusion in all sectors of STEM

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_614df83280a3372a8a170305&retmode=json
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Publications

The following publications were retrieved from PubMed:

The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication.

Nilsson-Payant BE, Uhl S, Grimont A, Doane AS, Cohen P, Patel RS, Higgins CA, Acklin JA, Bram Y, Chandar V, Blanco-Melo D, Panis M, Lim JK, Elemento O, Schwartz RE, Rosenberg BR, Chandwani R, tenOever BR.

J Virol. 2021 Sep 15; JVI0125721

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade.

Guzmán-Solís AA, Villa-Islas V, Bravo-López MJ, Sandoval-Velasco M, Wesp JK, Gómez-Valdés JA, Moreno-Cabrera ML, Meraz A, Solís-Pichardo G, Schaaf P, TenOever BR, Blanco-Melo D, Ávila Arcos MC.

Elife. 2021 Aug 5; (10)

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.

Si L, Bai H, Rodas M, Cao W, Oh CY, Jiang A, Moller R, Hoagland D, Oishi K, Horiuchi S, Uhl S, Blanco-Melo D, Albrecht RA, Liu WC, Jordan T, Nilsson-Payant BE, Golynker I, Frere J, Logue J, Haupt R, McGrath M, Weston S, Zhang T, Plebani R, Soong M, Nurani A, Kim SM, Zhu DY, Benam KH, Goyal G, Gilpin SE, Prantil-Baun R, Gygi SP, Powers RK, Carlson KE, Frieman M, tenOever BR, Ingber DE.

Nat Biomed Eng. 2021 Aug; 8(5)815-829

Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.

Hoagland DA, Møller R, Uhl SA, Oishi K, Frere J, Golynker I, Horiuchi S, Panis M, Blanco-Melo D, Sachs D, Arkun K, Lim JK, tenOever BR.

Immunity. 2021 Mar 9; 3(54)557-570.e5

Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition.

Nilsson-Payant BE, Blanco-Melo D, Uhl S, Escudero-Pérez B, Olschewski S, Thibault P, Panis M, Rosenthal M, Muñoz-Fontela C, Lee B, tenOever BR.

J Virol. 2021 Apr 12; 9(95)

Accepting Students For:

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Lab Information

Location: Fred Hutch
Building: Steam Plant Building
Room: S3-145
Box: E5-110