faculty

Lillian Cohn

lcohn@fredhutch.org
Assistant Professor

Fred Hutch

Computational Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Human immunology and HIV-1 persistence

Faculty Contact Information

Building: Eastlake Room: E5-150 Box: E5-110 Phone: 206-667-7209

Research Summary

My lab’s work focuses on the intersection between the human immune system and HIV; in particular, we’re interested in understanding the molecular, cellular, and physiologic barriers to HIV cure in people living with HIV (PLWH). My research is focused on the population of cells preventing HIV cure. These are primarily CD4+ T cells harboring latent proviruses. We take an immunologic and virologic approach to understanding the persistence of these cells in PLWH.

DEI Statement

My goal is to run a group whose research focuses on the advancement of human health. However, the work we do is not enough. How we do the work, and more specifically who we do it with, is of equal importance. Innovation, collaboration, and rigor resulting from diversity, equity, and inclusion (DEI) are critical to important scientific breakthroughs, and I am committed to leading an inclusive, diverse, and equitable team.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_614df9c1af2f9d5a0110d712&retmode=json
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Publications

The following publications were retrieved from PubMed:

Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.

Crawford ED, Acosta I, Ahyong V, Anderson EC, Arevalo S, Asarnow D, Axelrod S, Ayscue P, Azimi CS, Azumaya CM, Bachl S, Bachmutsky I, Bhaduri A, Brown JB, Batson J, Behnert A, Boileau RM, Bollam SR, Bonny AR, Booth D, Borja MJB, Brown D, Buie B, Burnett CE, Byrnes LE, Cabral KA, Cabrera JP, Caldera S, Canales G, Castañeda GR, Chan AP, Chang CR, Charles-Orszag A, Cheung C, Chio U, Chow ED, Citron YR, Cohen A, Cohn LB, Chiu C, Cole MA, Conrad DN, Constantino A, Cote A, Crayton-Hall T, Darmanis S, Detweiler AM, Dial RL, Dong S, Duarte EM, Dynerman D, Egger R, Fanton A, Frumm SM, Fu BXH, Garcia VE, Garcia J, Gladkova C, Goldman M, Gomez-Sjoberg R, Gordon MG, Grove JCR, Gupta S, Haddjeri-Hopkins A, Hadley P, Haliburton J, Hao SL, Hartoularos G, Herrera N, Hilberg M, Ho KYE, Hoppe N, Hosseinzadeh S, Howard CJ, Hussmann JA, Hwang E, Ingebrigtsen D, Jackson JR, Jowhar ZM, Kain D, Kim JYS, Kistler A, Kreutzfeld O, Kulsuptrakul J, Kung AF, Langelier C, Laurie MT, Lee L, Leng K, Leon KE, Leonetti MD, Levan SR, Li S, Li AW, Liu J, Lubin HS, Lyden A, Mann J, Mann S, Margulis G, Marquez DM, Marsh BP, Martyn C, McCarthy EE, McGeever A, Merriman AF, Meyer LK, Miller S, Moore MK, Mowery CT, Mukhtar T, Mwakibete LL, Narez N, Neff NF, Osso LA, Oviedo D, Peng S, Phelps M, Phong K, Picard P, Pieper LM, Pincha N, Pisco AO, Pogson A, Pourmal S, Puccinelli RR, Puschnik AS, Rackaityte E, Raghavan P, Raghavan M, Reese J, Replogle JM, Retallack H, Reyes H, Rose D, Rosenberg MF, Sanchez-Guerrero E, Sattler SM, Savy L, See SK, Sellers KK, Serpa PH, Sheehy M, Sheu J, Silas S, Streithorst JA, Strickland J, Stryke D, Sunshine S, Suslow P, Sutanto R, Tamura S, Tan M, Tan J, Tang A, Tato CM, Taylor JC, Tenvooren I, Thompson EM, Thornborrow EC, Tse E, Tung T, Turner ML, Turner VS, Turnham RE, Turocy MJ, Vaidyanathan TV, Vainchtein ID, Vanaerschot M, Vazquez SE, Wandler AM, Wapniarski A, Webber JT, Weinberg ZY, Westbrook A, Wong AW, Wong E, Worthington G, Xie F, Xu A, Yamamoto T, Yang Y, Yarza F, Zaltsman Y, Zheng T, DeRisi JL.

PLoS Pathog. 2020 Oct; 10(16)e1008966

The immune response fails to control HIV early in initial virus spread.

Cohn LB, Deeks SG.

J Clin Invest. 2020 Jun 1; 6(130)2803-2805

Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir.

Mendoza P, Jackson JR, Oliveira TY, Gaebler C, Ramos V, Caskey M, Jankovic M, Nussenzweig MC, Cohn LB.

J Exp Med. 2020 Jul 6; 7(217)

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

Cohn LB, Chomont N, Deeks SG.

Cell Host Microbe. 2020 Apr 8; 4(27)519-530

HIV-1 reservoir dynamics in CD4+ T cells.

Bruner KM, Cohn LB.

Curr Opin HIV AIDS. 2019 Mar; 2(14)108-114

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Eastlake
Room: E4-430
https://research.fredhutch.org/cohn/en.html