University of Washington
Biophysical and Structural Biology
Gene Expression, Cell Cycle & Chromosome Biology
Microbiology, Infection & Immunity
Chromosome organization and topoisomerase function in microbes
Faculty Contact Information
The Guo Laboratory studies the relationship between genome organization and essential DNA processes such as replication, transcription, and DNA segregation. We seek to understand (1) how DNA structuring proteins regulate the large molecular machines involved in genome maintenance and (2) the organization and molecular biological effects of local DNA structure. We utilize a diverse range of techniques including genetics, biochemistry, single-molecule experiments and high-throughput sequencing to understand molecular behaviors and their genomic consequences.
The following publications were retrieved from PubMed:
Guo MS, Kawamura R, Littlehale ML, Marko JF, Laub MT.
Elife. 2021 Jul 19; (10)
Lite TV, Grant RA, Nocedal I, Littlehale ML, Guo MS, Laub MT.
Elife. 2020 Oct 27; (9)
Guzzo M, Castro LK, Reisch CR, Guo MS, Laub MT.
mBio. 2020 Jan 14; 1(11)
Guo MS, Haakonsen DL, Zeng W, Schumacher MA, Laub MT.
Cell. 2018 Oct 4; 2(175)583-597.e23
Lalanne JB, Taggart JC, Guo MS, Herzel L, Schieler A, Li GW.
Cell. 2018 Apr 19; 3(173)749-761.e38
García-Bayona L, Guo MS, Laub MT.
Elife. 2017 Mar 21; (6)
Lima S, Guo MS, Chaba R, Gross CA, Sauer RT.
Science. 2013 May 17; 6134(340)837-41