Research Summary
The Guo Laboratory studies the relationship between genome organization and essential DNA processes such as replication, transcription, and DNA segregation. We seek to understand (1) how DNA structuring proteins regulate the large molecular machines involved in genome maintenance and (2) the organization and molecular biological effects of local DNA structure. We utilize a diverse range of techniques including genetics, biochemistry, single-molecule experiments and high-throughput sequencing to understand molecular behaviors and their genomic consequences.
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Publications
The following publications were retrieved from PubMed: