faculty

Monica Guo

msguo@uw.edu
Assistant Professor

University of Washington

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Microbiology, Infection & Immunity

Chromosome organization and topoisomerase function in microbes

Faculty Contact Information

Building: SLU F building Room: F831 Box: 358071 Phone: 206-685-4649 https://www.guolabuw.org/

Research Summary

The Guo Laboratory studies the relationship between genome organization and essential DNA processes such as replication, transcription, and DNA segregation. We seek to understand (1) how DNA structuring proteins regulate the large molecular machines involved in genome maintenance and (2) the organization and molecular biological effects of local DNA structure. We utilize a diverse range of techniques including genetics, biochemistry, single-molecule experiments and high-throughput sequencing to understand molecular behaviors and their genomic consequences.

DEI Statement

My goal as a mentor is to help trainees develop into the scientists and colleagues they wish to be. I work with each mentee to identify their needs in order to help them build up their skills, training, and vision in order to achieve their goals. In practice, my mentoring is dynamic and responsive in order to adapt to trainees’ changing needs as they progress through their research and as they evolve as scientists.

Training Summary

Building Healthy Workplaces Workshop – 2022

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_6391619003ccb6188741e640&retmode=json
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Publications

The following publications were retrieved from PubMed:

High-resolution, genome-wide mapping of positive supercoiling in chromosomes.

Guo MS, Kawamura R, Littlehale ML, Marko JF, Laub MT.

Elife. 2021 Jul 19; (10)

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library.

Lite TV, Grant RA, Nocedal I, Littlehale ML, Guo MS, Laub MT.

Elife. 2020 Oct 27; (9)

A CRISPR Interference System for Efficient and Rapid Gene Knockdown in Caulobacter crescentus.

Guzzo M, Castro LK, Reisch CR, Guo MS, Laub MT.

mBio. 2020 Jan 14; 1(11)

A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication.

Guo MS, Haakonsen DL, Zeng W, Schumacher MA, Laub MT.

Cell. 2018 Oct 4; 2(175)583-597.e23

Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry.

Lalanne JB, Taggart JC, Guo MS, Herzel L, Schieler A, Li GW.

Cell. 2018 Apr 19; 3(173)749-761.e38

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