Biophysical and Structural Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Recombination and DNA break repair
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With genetics, enzymology, cytology, deep-sequencing, and single-molecule FRET, we study how broken DNA is repaired and how genetic recombinants arise. We study E. coli’s DNA helicase-nuclease RecBCD and how special DNA sequences (Chi hotspots) control its conformation and activities. In fission yeast, we study how meiotic DNA break hotspots cluster and interact; how repeated pericentric DNA and rDNA are kept silent by heterochromatin and RNAi; and how Holliday junctions are distributed across the genome. Two aims are to understand the origin of certain diseases and to find novel antibiotics.