faculty

Gerry Smith

gsmith@fredhutch.org
Member

Fred Hutch

Genome Sciences

Basic Sciences

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Recombination and DNA break repair

Faculty Contact Information

Building: Weintraub Room: A1-155 Box: A1-162 Phone: 206-667-4438 Alt Phone: 206-667-4432 http://sharedresources.fredhutch.org/profile/smith-gerald

Research Summary

With genetics, enzymology, cytology, deep-sequencing, and single-molecule FRET, we study how broken DNA is repaired and how genetic recombinants arise. We study E. coli’s DNA helicase-nuclease RecBCD and how special DNA sequences (Chi hotspots) control its conformation and activities. In fission yeast, we study how meiotic DNA break hotspots cluster and interact; how repeated pericentric DNA and rDNA are kept silent by heterochromatin and RNAi; and how Holliday junctions are distributed across the genome. Two aims are to understand the origin of certain diseases and to find novel antibiotics.

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Publications

The following publications were retrieved from PubMed:

Distributing meiotic crossovers for optimal fertility and evolution.

Nambiar M, Chuang YC, Smith GR.

DNA Repair (Amst). 2019 Sep; (81)102648

The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme.

Amundsen SK, Smith GR.

Nucleic Acids Res. 2019 Jan 10; 1(47)197-209

Physical basis for long-distance communication along meiotic chromosomes.

Fowler KR, Hyppa RW, Cromie GA, Smith GR.

Proc Natl Acad Sci U S A. 2018 Oct 2; 40(115)E9333-E9342

<i>wtf</i> genes are prolific dual poison-antidote meiotic drivers.

Nuckolls NL, Bravo Núñez MA, Eickbush MT, Young JM, Lange JJ, Yu JS, Smith GR, Jaspersen SL, Malik HS, Zanders SE.

Elife. 2017 Jun 20; (6)

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A1-149
Box: A1-162
Phone: 206-667-4432
Alt Phone: 206-667-4431
http://research.fhcrc.org/smith/en.html