faculty

Benjamin Freedman

benof@uw.edu
Associate Professor

University of Washington

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Human organoids to understand development and disease

Faculty Contact Information

Building: 850 Republican St Room: N530 Box: 358056 Phone: 510-837-1922

Research Summary

I seek to understand how microscopic events in human cells produce intricate, functional macroscopic organs and tissues. Hallmarks of my career include 1) the application of stem cells for studying disease and regeneration, 2) quantitative comparison of gene mutants, 3) functional assays providing stoichiometric insight into protein dynamics and activity, and 4) reconstitution of complex physiological phenomena in defined component systems in vitro. I am one of the original inventors of kidney organoids and first combined these with genome editing to create phenotypic models of disease.

DEI Statement

I am committed to a diverse, inclusive, equitable environment. Our group is highly diverse. For the past 5 years, I have mentored 1-2 URM high school students per year for the STEMPREP summer program. I have a strong track record as a mentor for female and URM trainees, who have produced high-impact papers and competed successfully for grants and faculty jobs. I recently published a Kidney360 paper on APOL1 kidney disease, which predominantly affects African Americans. I am a long-time ally and was a precinct captain for Barack Obama.

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Publications

The following publications were retrieved from PubMed:

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations.

Helms L, Marchiano S, Stanaway IB, Hsiang TY, Juliar BA, Saini S, Zhao YT, Khanna A, Menon R, Alakwaa F, Mikacenic C, Morrell ED, Wurfel MM, Kretzler M, Harder JL, Murry CE, Himmelfarb J, Ruohola-Baker H, Bhatraju PK, Gale M Jr, Freedman BS.

JCI Insight. 2021 Nov 12;

Skeletal muscle regeneration with robotic actuation-mediated clearance of neutrophils.

Seo BR, Payne CJ, McNamara SL, Freedman BR, Kwee BJ, Nam S, de Lázaro I, Darnell M, Alvarez JT, Dellacherie MO, Vandenburgh HH, Walsh CJ, Mooney DJ.

Sci Transl Med. 2021 Oct 6; 614(13)eabe8868

Tendinopathy and tendon material response to load: What we can learn from small animal studies.

Williamson PM, Freedman BR, Kwok N, Beeram I, Pennings J, Johnson J, Hamparian D, Cohen E, Galloway JL, Ramappa AJ, DeAngelis JP, Nazarian A.

Acta Biomater. 2021 Oct 15; (134)43-56

Multivalent designed proteins protect against SARS-CoV-2 variants of concern.

Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger-Gericke A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken S, Ljubetič A, Edman N, Ueda G, Chow C, Addetia A, Panpradist N, Gale M, Freedman BS, Lutz BR, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D.

bioRxiv. 2021 Jul 7;

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

Gopalan J, Omar MH, Roy A, Cruz NM, Falcone J, Jones KN, Forbush KA, Himmelfarb J, Freedman BS, Scott JD.

Elife. 2021 Jul 12; (10)



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Lab Information

Location: South Lake Union
Building: 850 Republican St
Room: N530
http://www.freedmanlab.com/