faculty

Devin Schweppe

dkschwep@uw.edu

Assistant Professor

University of Washington

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Systems proteomics and intelligent mass spectrometry

Faculty Contact Information

Building: Foege Building Room: S-041 Box: Box 355065 Phone: 206-616-6031 http://www.schweppelab.org/

Research Summary

Modern proteomics enables quantitation of up to 10,000 proteins from complex cellular matrices. At the interface of cell biology, biochemistry and proteomics, we are attempting to understand how proteins govern key cellular pathways involved in normal cellular function and disease. We are building adaptive strategies to harness spectral data on the millisecond time scale to determine quantitative disparities between cellular states. Intelligent data acquisition in mass spectrometry driven proteomics can enhance the accuracy and efficiency of proteomics data collection.

DEI Statement

The lab is dedicated to providing a harassment-free workplace for everyone, regardless of gender, gender identity/expression, age, sexual orientation, disability, socioeconomics, physical appearance, body size, race, national origin, or religion. We do not tolerate harassment of lab members in any form. All lab members/visitors are expected to agree to the lab’s code of conduct (lab handbook). We do not tolerate the perpetuation of stereotypes; we do not tolerate other acts of microaggression. We are a team. We stand up for one another. We learn from each other. We hold each other accountable.

Training Summary

As a member of the Genome Science faculty, I have engaged in DEI training with both the Lavender Rights Project and Greg Taylor. These trainings were focused in part on addressing the effects of racism, implicit biases, and micro/macroaggressions. As a mentor, I participated in the New Faculty Transition Program to learn how to build upon skills to run a successful research program. This program included mentoring from leaders in the Seattle research community.

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Publications

The following publications were retrieved from PubMed:

Strategies for mass spectrometry-based phosphoproteomics using isobaric tagging.

Liu X, Fields R, Schweppe DK, Paulo JA.

Expert Rev Proteomics. 2021 Sep; 9(18)795-807

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Huttlin EL, Bruckner RJ, Navarrete-Perea J, Cannon JR, Baltier K, Gebreab F, Gygi MP, Thornock A, Zarraga G, Tam S, Szpyt J, Gassaway BM, Panov A, Parzen H, Fu S, Golbazi A, Maenpaa E, Stricker K, Guha Thakurta S, Zhang T, Rad R, Pan J, Nusinow DP, Paulo JA, Schweppe DK, Vaites LP, Harper JW, Gygi SP.

Cell. 2021 May 27; 11(184)3022-3040.e28

Advances in quantitative high-throughput phosphoproteomics with sample multiplexing.

Paulo JA, Schweppe DK.

Proteomics. 2021 May; 9(21)e2000140

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries.

Kuljanin M, Mitchell DC, Schweppe DK, Gikandi AS, Nusinow DP, Bulloch NJ, Vinogradova EV, Wilson DL, Kool ET, Mancias JD, Cravatt BF, Gygi SP.

Nat Biotechnol. 2021 May; 5(39)630-641

Improved Monoisotopic Mass Estimation for Deeper Proteome Coverage.

Rad R, Li J, Mintseris J, O'Connell J, Gygi SP, Schweppe DK.

J Proteome Res. 2021 Jan 1; 1(20)591-598

PubMed Collection Link

Accepting Students For:

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Lab Information

Location: University of Washington
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Room: S-041
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