faculty

Richard Adeyemi

radeyemi@fredhutch.org
Assistant Professor

Fred Hutch

Basic Sciences

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Characterization of Genome Maintenance Mechanisms

Faculty Contact Information

Building: Weintraub Room: A1-159 Box: A1-162 Phone: 206-667-6263 https://www.fredhutch.org/en/faculty-lab-directory/adeyemi-richard.html

Research Summary

Accurate transmission of genetic information is critical for cellular survival and prevention of several diseases. Our lab is interested in understanding the molecular mechanisms of genome maintenance; how the DNA repair machinery is coordinated in response to different types of cellular insults, how these processes are dysregulated during genetic diseases, infections, aging and cancer, and how such knowledge can potentially be exploited towards novel therapies. To this end, we use interdisciplinary approaches to address the role of critical proteins in several genome maintenance pathways.

DEI Statement

The Adeyemi lab welcomes everyone regardless of their background. We believe that science thrives in a welcoming, collegial environment in which diverse opinions and approaches are welcomed and encouraged. As an underrepresented minority in the sciences, I benefited from having incredible mentors that valued diversity, and I am committed to and passionate about improving diversity by creating a lab environment that fosters inclusion and by mentoring scientists from historically underrepresented backgrounds in the sciences.

Training Summary

Bias Mitigation Education: Grounding & Commitment

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_638dccd5e8c88a321159d27f&retmode=json
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Publications

The following publications were retrieved from PubMed:

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.

Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ.

Mol Cell. 2021 Nov 4; 21(81)4440-4456.e7

A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.

Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski K.

Cancer Cell. 2020 May 11; 5(37)705-719.e6

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ.

Mol Cell. 2019 Mar 7; 5(73)885-899.e6

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ.

Mol Cell. 2015 Oct 15; 2(60)280-93

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: Fred Hutch
Building: Weintraub
Room: A2-123
https://research.fredhutch.org/adeyemi/en.html