Research Summary
Our laboratory studies the mitotic spindle, an exquisite molecular machine that organizes and separates duplicated chromosomes during cell division, thereby ensuring equal partitioning of the genetic material. To uncover how this machine operates, we are reconstituting spindle functions using pure components and applying new biophysical tools for manipulating and tracking individual molecules, such as laser trapping and ultrasensitive fluorescence microscopy.
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Publications
The following publications were retrieved from PubMed:
The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19CCAN Complex in Meiotic Kinetochore Assembly.
Borek WE, Vincenten N, Duro E, Makrantoni V, Spanos C, Sarangapani KK, de Lima Alves F, Kelly DA, Asbury CL, Rappsilber J, Marston AL.
Curr Biol. 2021 Jan 25; 2(31)283-296.e7
