faculty

Steven Hahn

shahn@fredhutch.org
Professor

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Mechanisms of Eukaryotic Gene Regulation

Faculty Contact Information

Building: A1 Room: 201 Box: A1-162 Phone: 206-667-5261 http://research.fhcrc.org/hahn/en.html

Research Summary

We use a multi-disciplinary approach including molecular genetics, genomics, computational biology, biochemistry, structural, and biophysical methods to uncover new mechanisms used in gene regulation. Much of our work uses new technologies and approaches to understand the action of large protein complexes, which are often regulated by surprisingly flexible and dynamic protein-protein interactions. These mechanisms form the molecular basis for understanding regulated and rate-limiting steps that are at the endpoint of many signaling pathways controlling growth, homeostasis and stress response.

DEI Statement

Diversity is a strength, and all people deserve an equal opportunity to succeed. Our society can be stronger with ideas and contributions made by people from diverse backgrounds and cultural identities. I strive for an inclusive laboratory culture where everyone is treated with respect and has equal opportunities to succeed, have their voices heard, and be recognized for their accomplishments. My goals for diversity and inclusion in the laboratory are to support the science of a diverse research team and to create a supportive and respectful training environment.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_62f51b84df182e5223150580&retmode=json
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Publications

The following publications were retrieved from PubMed:

Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4.

Tuttle LM, Pacheco D, Warfield L, Wilburn DB, Hahn S, Klevit RE.

Nat Commun. 2021 Apr 13; 1(12)2220

The Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning.

Tomko EJ, Luyties O, Rimel JK, Tsai CL, Fuss JO, Fishburn J, Hahn S, Tsutakawa SE, Taatjes DJ, Galburt EA.

J Mol Biol. 2021 Jul 9; 14(433)166813

A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning.

Erijman A, Kozlowski L, Sohrabi-Jahromi S, Fishburn J, Warfield L, Schreiber J, Noble WS, Söding J, Hahn S.

Mol Cell. 2020 Jun 4; 5(78)890-902.e6

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA.

Donczew R, Warfield L, Pacheco D, Erijman A, Hahn S.

Elife. 2020 Jan 8; (9)



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Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A1-201
Box: A1-162
Phone: 206-667-5263
http://research.fhcrc.org/hahn/en.html