Biophysical and Structural Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Chromosome structure and function
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We perform research on chromatin dynamics, transcriptional regulation, and centromere maintenance, and we develop experimental and computational tools for studying these processes. Recent methods map nucleosome turnover, transcription factors, DNA torsion and nascent chromatin landscapes genome-wide at high resolution. Recent application of these tools has identified the nucleosome barrier to transcription, revealed a competition between nucleosomes and transcription factors behind the replication fork, and determined the molecular organization of centromeric nucleosomes.