Steven Henikoff


Fred Hutch, 

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Chromosome structure and function

Faculty Contact Information

Building: Weintraub Room: A1-111 Box: A1-162 Phone: 206-667-4515 Alt Phone: 206-667-5707 http://research.fhcrc.org/henikoff/en.html

Lab Information

Location: Fred Hutch Building: Weintraub Room: A1-111 Box: A1-162 Phone: 206-667-4509 Alt Phone: (206) 667-5707 http://research.fhcrc.org/henikoff/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter


The following publications were retrieved from PubMed:

No strand left behind.

Ahmad K, Henikoff S.

Science. 2018 Sep 28; 6409(361)1311-1312

MINCE-Seq: Mapping In Vivo Nascent Chromatin with EdU and Sequencing.

Ramachandran S, Henikoff S.

Methods Mol Biol. 2018; (1832)159-168

Pioneers Invade the Nucleosomal Landscape.

Henikoff S, Ramachandran S.

Mol Cell. 2018 Jul 19; 2(71)193-194

Transcribing Centromeres: Noncoding RNAs and Kinetochore Assembly.

Talbert PB, Henikoff S.

Trends Genet. 2018 Aug; 8(34)587-599

Simultaneous Discovery of Cell-Free DNA and the Nucleosome Ladder.

Henikoff S, Church GM.

Genetics. 2018 May; 1(209)27-29

Research Summary

We perform research on chromatin dynamics, transcriptional regulation, and centromere maintenance, and we develop experimental and computational tools for studying these processes. Recent methods map nucleosome turnover, transcription factors, DNA torsion and nascent chromatin landscapes genome-wide at high resolution. Recent application of these tools has identified the nucleosome barrier to transcription, revealed a competition between nucleosomes and transcription factors behind the replication fork, and determined the molecular organization of centromeric nucleosomes.