Research Summary
The Villen lab is interested in the organization principles of signaling. We develop and apply proteomic technologies that provide a systems-level view of signaling to reveal signaling components, their connections, and their functional regulation. Our long-term goal is to understand the wiring diagram of a cell at such resolution that we can predict and control cellular output, encompassing molecules, shapes, and functions.
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Publications
The following publications were retrieved from PubMed:
PKC downregulation upon rapamycin treatment attenuates mitochondrial disease.
Martin-Perez M, Grillo AS, Ito TK, Valente AS, Han J, Entwisle SW, Huang HZ, Kim D, Yajima M, Kaeberlein M, Villén J.
Nat Metab. 2020 Dec; 12(2)1472-1481
Author Correction: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Calejman CM, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA.
Nat Commun. 2020 Sep 8; 1(11)4585
Calcium-binding proteins are altered in the cerebellum in schizophrenia.
Vidal-Domènech F, Riquelme G, Pinacho R, Rodriguez-Mias R, Vera A, Monje A, Ferrer I, Callado LF, Meana JJ, Villén J, Ramos B.
PLoS One. 2020; 7(15)e0230400
