faculty

Judit Villen

jvillen@uw.edu
Assistant Professor

University of Washington

Genome Sciences

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Cell signaling and Proteomics

Faculty Contact Information

Building: Foege Room: S133C Box: 355065 Phone: 206-685-1490

Research Summary

The Villen lab is interested in the organization principles of signaling. We develop and apply proteomic technologies that provide a systems-level view of signaling to reveal signaling components, their connections, and their functional regulation. Our long-term goal is to understand the wiring diagram of a cell at such resolution that we can predict and control cellular output, encompassing molecules, shapes, and functions.

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Publications

The following publications were retrieved from PubMed:

Modulating Mistranslation Potential of tRNA<sup>Ser</sup> in <i>Saccharomyces cerevisiae</i>.

Berg MD, Zhu Y, Genereaux J, Ruiz BY, Rodriguez-Mias RA, Allan T, Bahcheli A, Villén J, Brandl CJ.

Genetics. 2019 Sep 4;

Thesaurus: quantifying phosphopeptide positional isomers.

Searle BC, Lawrence RT, MacCoss MJ, Villén J.

Nat Methods. 2019 Aug; 8(16)703-706

Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry.

Searle BC, Pino LK, Egertson JD, Ting YS, Lawrence RT, MacLean BX, Villén J, MacCoss MJ.

Nat Commun. 2018 Dec 3; 1(9)5128

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T, Detilleux D, Rodriguez-Mias RA, Faux C, Romeo Y, Franz-Wachtel M, Krug K, Maček B, Villén J, Petersen J, Helmlinger D.

EMBO Rep. 2017 Dec; 12(18)2197-2218

The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.

Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villén J, Harris TE.

J Biol Chem. 2017 Dec 15; 50(292)20481-20493

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Lab Information

Location: University of Washington
Building: Foege
Room: S133A
Box: 355065
Phone: 206-543-1880
http://villenlab.gs.washington.edu/