University of Washington,
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Structure and regulation of the mammalian X chromosome and role in aneuploidy
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The Disteche lab studies the structure and regulation of the sex chromosomes and their role in aneuploidy. The fundamental difference between males (XY) and females (XX) led to the evolution of dosage compensation mechanisms, including silencing of one X chromosome in females. Ongoing studies address the 3D structure and nuclear location of the inactive X chromosome in single cells and the function of long non-coding RNAs in maintenance of silencing. We also investigate the role of genes that escape X inactivation in sex differences and in diseases caused by aneuploidy.