faculty

Christine Disteche

cdistech@u.washington.edu

University of Washington,

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Structure and regulation of the mammalian X chromosome and role in aneuploidy

Faculty Contact Information

Building: Health Sciences Room: C526 Box: BOX357470 Phone: 206-543-0716 http://www.pathology.washington.edu/faculty/disteche

Lab Information

Location: University of Washington Building: Health Sciences Room: C526 Box: BOX357470 Phone: 206-685-2801 http://depts.washington.edu/disteche/index.html

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Permanent

Research Summary

The Disteche lab studies the structure and regulation of the sex chromosomes and their role in aneuploidy. The fundamental difference between males (XY) and females (XX) led to the evolution of dosage compensation mechanisms, including silencing of one X chromosome in females. Ongoing studies address the 3D structure and nuclear location of the inactive X chromosome in single cells and the function of long non-coding RNAs in maintenance of silencing. We also investigate the role of genes that escape X inactivation in sex differences and in diseases caused by aneuploidy.